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To the Editor:—
In "Treatment of the Urethral Syndrome in Women" (184:984, 1963), Robert Zufall, MD, described a group of patients with urinary frequency, dysuria, and other symptoms of inflammation of the lower urinary tract in whom corroborative physical and laboratory findings were minimal if not absent altogether. He wrote, "The urethra has been commonly blamed for this syndrome, and many experienced observers find urethral stenosis, edema, hyperemia, granularity, polyps at the neck of the bladder, or exudate on the trigone," but noted himself, "For the majority of patients in this series, diligent search revealed nothing at all different from the urethras, bladder necks, and trigones of patients who were cystoscoped for unrelated conditions, who had no 'urethral' symptoms." About one third of his patients improved for more than 12 weeks with any form of treatment tried, including intramuscular injections of sterile water.To determine quantitatively whether or not
Clarke BG. Chronic Urethrocystitis In Women. JAMA. 1967;199(3):221. doi:10.1001/jama.1967.03120030125032
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