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January 23, 1967

Thyroid Carcinoma Ten Years After Sodium Iodide I131 Treatment

Author Affiliations

From the Radioisotope Laboratory, Division of Metabolism and Endocrinology, and the Department of Medicine, Michael Reese Hospital and Medical Center, Chicago.

JAMA. 1967;199(4):247-251. doi:10.1001/jama.1967.03120040057009

There was coexistence of thyroid carcinoma and hyperthyroidism in a 37-year-old woman previously (apparently successfully) treated with sodium iodide I 131 for thyrotoxicosis. There was an uncommon sequence of events in this case and a possible relationship between131I therapy and subsequent development of thyroid carcinoma existed. Since the reported frequency of thyroid carcinoma following131I therapy in the adult is well within the range of statistical coincidence, no basis for a cause and effect relationship presently exists.

Pemberton, J.DeJ., and Black, B.M.:  The Association of Carcinoma of the Thyroid Gland and Exophthalmic Goiter ,  Surg Clin N Amer 28:935-952 ( (Aug) ) 1948.
Sokal, J.E.:  Incidence of Malignancy in Toxic and Nontoxic Nodular Goiter ,  JAMA 154:1321-1325 ( (April 17) ) 1954.Crossref
Eastcott, H.H.G., and Hepinstall, R.H.:  A Case of Carcinoma of the Thyroid Arising in a Diffuse Toxic Goiter ,  Brit J Surg 45: 297-298 ( (Sept) ) 1958.Crossref
Koneman, E.W., and Sawyer, K.C.:  Carcinoma of the Thyroid Occurring in a Diffuse Toxic Goiter ,  Amer J Surg 101:245-247 ( (Feb) ) 1961.Crossref
Holsinger, D.R., and Stevens, J.E.:  Hyperthyroidism in a Case of Thyroid Carcinoma Presenting as Diabetes Mellitus ,  Ann Intern Med 46:791-795 ( (April) ) 1957.Crossref
Olen, E., and Klinck, G.H.:  Hyperthyroidism and Thyroid Cancer ,  Arch Path 81:531-535 ( (June) ) 1966.
Rawson, R.W.; Rall, J.E.; and Robbins, J.:  Uses and Misuses of Radioactive Iodine in the Treatment of Cancer of the Thyroid ,  Arch Intern Med 92:299-307 ( (Sept) ) 1953.Crossref
Vickery, A.L., Jr.: " Thyroid Alterations Due to Irradiation ," in Hazard, J.B., and Smith, D.E. (eds.):  The Thyroid (International Academy of Pathology Monograph) , Baltimore: Williams & Wilkins Co., 1964, pp 183-206.
Volpe, R., et al:  Radioactive Iodine in the Treatment of Hyperthyroidism: Experience at the Toronto General Hospital, 1950-1958 ,  Canad Med Assoc J 83:1407-1413 ( (Dec 31) ) 1960.
Green, M., and Wilson, G.M.:  Thyrotoxicosis Treated by Surgery or Iodine-131 With Special Reference to Development of Hypothyroidism ,  Brit Med J 1:1005-1010 ( (April 18) ) 1964.Crossref
Evans, R.D.:  Quantitative Aspects of Radiation Carcinogenesis in Humans .  Acta de l'Union Int contre le Cancer 6:1229, 1950.
Duffy, B.J., Jr., and Fitzgerald, P.J.:  Cancer of Thyroid in Children: Report of 28 Cases ,  J Clin Endocr 10:1296-1308 ( (Oct) ) 1950.Crossref
Simpson, C.L.; Hempelmann, L.H.; and Fuller, L.M.:  Neoplasia in Children Treated With X-Rays in Infancy for Thymic Enlargement ,  Radiology 64:840-845 ( (June) ) 1955.
Clark, D.E.:  Association of Irradiation With Cancer of Thyroid in Children and Adolescents ,  JAMA 159:1007-1009 ( (Nov 5) ) 1955.Crossref
Wilson, G.M., et al:  Thyroid Neoplasms Following Irradiation ,  Brit Med J 2:929-934 ( (Oct 18) ) 1958.Crossref
Winship, T., and Rosvoll, R.V.:  Childhood Thyroid Carcinoma ,  Cancer 14:734-743 ( (July) -Aug) 1961.Crossref
Karlan, M.S.; Pollock, W.F.; and Snyder, W.H., Jr.:  Carcinoma of the Thyroid Following Treatment of Hyperthyroidism, With Radioactive Iodine ,  Calif Med 101:196-199 ( (Sept) ) 1964.
Sheline, G.E., et al:  Thyroid Nodules Occurring Late After Treatment of Thyrotoxicosis With Radioiodine ,  J Clin Endocr 22:8-18 ( (Jan) ) 1962.Crossref
Goolden, A.W.G.:  Carcinoma of the Thyroid Following Irradiation ,  Brit Med J 2:954-955 ( (Oct 18) ) 1958.Crossref
Willis, J.:  Thyroid Carcinoma After Irradiation in Adult Life ,  Brit Med J 2:550 ( (Sept 26) ) 1959.Crossref
Hanford, J.M.; Quimby, E.H.; and Frantz, V.K.:  Cancer Arising Many Years After Radiation Therapy: Incidence After Irradiation of Benign Lesions in the Neck ,  JAMA 181:404-410 ( (Aug 4) ) 1962.Crossref
Hollingsworth, D.R., et al:  Thyroid Disease: A Study in Hiroshima, Japan ,  Medicine 42:47-71 ( (Jan) ) 1963.Crossref
Blomfield, G.W., et al:  Treatment of Thyrotoxicosis With I131: A Review of 500 Cases ,  Brit Med J 1:63-74 ( (Jan 10) ) 1959.Crossref
Chapman, E.M., and Maloof, F.:  The Use of Radioactive Iodine in the Diagnosis and Treatment of Hyperthyroidism: Ten Years' Experience ,  Medicine 34:261-321 ( (Sept) ) 1955.Crossref
Volpe, R., et al:  Radioactive Iodine in the Treatment of Hyperthyroidism: Experience at the Toronto General Hospital, 1950-1958 ,  Canad Med Assoc J 84:84-87 ( (Jan 14) ) 1961.