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Article
February 27, 1967

Serum Haptoglobin: A Valuable Diagnostic Aid in Suspected Hemolytic Transfusion Reactions

Author Affiliations

From the Research and Medicine Department, Veterans Administration Hospital (Drs Fink and Petz) and the Department of Pathology, St Luke's Hospital (Dr. Black) San Francisco.

JAMA. 1967;199(9):615-618. doi:10.1001/jama.1967.03120090057010
Abstract

A study of a large group of patients was undertaken to determine the effect of compatible whole blood transfusion on the level of serum haptoglobin in order to assess the usefulness of this measurement as a diagnostic test of hemolytic transfusion reactions. In the entire series of 185 patients there were only four cases in which the pretransfusion level was within normal limits and the posttransfusion level was less than 30 mg/100 ml. In all four cases, clinical information is available which adequately explains the drop in serum haptoglobin level. In the only three instances of hemolytic transfusion reactions in the San Francisco area that are known to the authors, the serum haptoglobin determined immediately after the reaction was zero. It is concluded that the measurement of serum haptoglobin is a valuable diagnostic aid in suspected hemolytic transfusion reaction and should be a routine part of the evaluation in all such cases.

References
1.
Brus, I., and Lewis, S.M.:  The Haptoglobin Content of Serum in Haemolytic Anaemia ,  Brit J Haemat 5:348-355 ( (Oct) ) 1959.Crossref
2.
Shinton, M.K.; Richardson, R.W.; and Williams, J.D.F.:  Diagnostic Value of Serum Haptoglobin ,  J Clin Path 18:114-118 ( (Jan) ) 1965.Crossref
3.
Langley, G.R.; Owen, J.A.; and Padanyi, R.:  The Effect of Blood Transfusions on Serum Haptoglobin .  Brit J Haemat 8:392-400 ( (Oct) ) 1962.Crossref
4.
Owen, J.A.; Better, F.C.; and Hoban, J.:  A Simple Method for the Determination of Serum Haptoglobins ,  J Clin Path 13:163-164 ( (March) ) 1960.Crossref
5.
Rowe, D.S.:  A Rapid Method for the Estimation of Serum Haptoglobin ,  J Clin Path 14:205-206 ( (March) ) 1961.Crossref
6.
Nosslin, B.F., and Numan, M.:  Haptoglobin Determination in Diagnosis of Haemolytic Diseases ,  Lancet 1:1000-1001 ( (May 10) ) 1958.Crossref
7.
Laurell, C.B., and Nyman, M.:  Studies on the Serum Haptoglobin Level in Hemoglobinemia and its Influence on Renal Excretion of Hemoglobin ,  Blood 12:493-506 ( (June 6) ) 1957.
8.
Owen, J.A.; MacKay, I.R.; and Got, O.:  Serum Haptoglobins in Hepatobiliary Disease ,  Brit Med J 2:1454-1457 ( (June 6) ) 1959.Crossref
9.
Scheffé, H.:  The Analysis of Variance , New York: John Wiley & Sons, Inc., 1959, pp 112-119.
10.
Mollison, P.L.:  Blood Transfusion in Clinical Medicine , Oxford, England: Blackwell Scientific Publications, 1961.
11.
Alper, C.A., et al:  Haptoglobin Synthesis: I. In Vivo Studies of the Production of Haptoglobin, Fibrinogen, and β-globulin by the Canine Liver ,  J Clin Invest 44:574-581 ( (April) ) 1965.Crossref
12.
Peters, J.H., and Alper, C.A.:  Haptoglobin Synthesis: II. Cellular Localization Studies ,  J Clin Invest 45:314-320 ( (March) ) 1966.Crossref
13.
van Loghem, J.J., et al:  Increased Red Cell Destruction in the Absence of Demonstrable Antibodies in Vitro ,  Transfusion 5:525-532 ( (Nov) -Dec) 1965.Crossref
14.
van der Hart, M.: et al:  A Haemolytic Transfusion Reaction Without Demonstrable Antibodies in Vitro ,  Vox Sang 8:363-370 ( (May) -June) 1963.Crossref
15.
Stewart, J.W., and Mollison, P.L.:  Rapid Destruction of Apparently Compatible Red Cells ,  Brit Med J 1:1274-1275 ( (May 16) ) 1959.Crossref
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