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November 2021 - July 1883

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Issue

November 23/30, 2021, Vol 326, No. 20, Pages 1995-2087

In This Issue of JAMA

Audio Highlights

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JAMA. 2021;326(20):e2018241. doi:10.1001/jama.2020.18241
Original Investigation

Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis: The RESTORE Randomized Clinical Trial

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JAMA. 2021;326(20):2021-2030. doi:10.1001/jama.2021.19415

This randomized trial assesses the effect of injections of platelet-rich plasma vs saline placebo on 12-month changes in knee pain scores and medial tibial cartilage volume among patients with symptomatic mild to moderate knee osteoarthritis.

Association of Bariatric Surgery With Major Adverse Liver and Cardiovascular Outcomes in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis

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JAMA. 2021;326(20):2031-2042. doi:10.1001/jama.2021.19569

This cohort study investigates the association between bariatric surgery and incident major adverse liver outcomes and major adverse cardiovascular events in patients with obesity and biopsy-proven fibrotic NASH without cirrhosis.

Association Between mRNA Vaccination and COVID-19 Hospitalization and Disease Severity

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JAMA. 2021;326(20):2043-2054. doi:10.1001/jama.2021.19499

This case-control study explores the association between vaccination with mRNA COVID-19 vaccines and hospitalization for COVID-19, and, among patients hospitalized with COVID-19, the association with progression to critical disease in adults from 18 US states.

Research Letter

Trends in Obesity Prevalence Among Adults Aged 18 Through 25 Years, 1976-2018

Abstract Full Text
JAMA. 2021;326(20):2073-2074. doi:10.1001/jama.2021.16685

This study uses nationally representative data from the National Health and Nutrition Examination Survey to examine changes in obesity prevalence in the US over the last 4 decades among adults aged 18 through 25 years.

Incidence of Pancreatic Cancer by Age and Sex in the US, 2000-2018

Abstract Full Text
JAMA. 2021;326(20):2075-2077. doi:10.1001/jama.2021.18859

This study uses data from the Surveillance Epidemiology and End Results database to perform an age- and sex-specific time trend analysis of pancreatic cancer incidence rates in US adults.

Viewpoint

The Self-directed Medical Student Curriculum

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JAMA. 2021;326(20):2005-2006. doi:10.1001/jama.2021.16312

This Viewpoint discusses the growing role of medical students in shaping their own education and outlines the measures needed to ensure that medical student–directed learning remains aligned with the educational aims of the medical discipline.

Contraception Requirements in Clinical Trials: Considerations From Studies on Sexually Transmitted Infections

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JAMA. 2021;326(20):2007-2008. doi:10.1001/jama.2021.19473

This Viewpoint proposes a risk-based approach toward contraception use in clinical trials of investigational products, which could improve access and inclusivity for individuals with pregnancy potential who are at risk for the outcomes of interest.

Twenty Years After the Anthrax Terrorist Attacks of 2001: Lessons Learned and Unlearned for the COVID-19 Response

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JAMA. 2021;326(20):2009-2010. doi:10.1001/jama.2021.19292

This Viewpoint discusses the public health emergency preparedness response strategies instituted in the US after the anthrax attacks of 2001 in the context of the gaps in public health readiness that were exposed by the COVID-19 pandemic.

A Piece of My Mind

Taking Down the Shingle

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JAMA. 2021;326(20):2011. doi:10.1001/jama.2021.20106

In this narrative medicine essay, a psychiatrist reflects on the lasting effects of her practice after it closes, understanding that its memory will be preserved by her patients.

Editorial

Platelet-Rich Plasma for Osteoarthritis and Achilles Tendinitis

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JAMA. 2021;326(20):2012-2014. doi:10.1001/jama.2021.19540

Bariatric Surgery as a Strategy for Improving Outcomes in Nonalcoholic Steatohepatitis

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JAMA. 2021;326(20):2015-2017. doi:10.1001/jama.2021.17451

Understanding Breakthrough Infections Following mRNA SARS-CoV-2 Vaccination

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JAMA. 2021;326(20):2018-2020. doi:10.1001/jama.2021.19063
Review

Management of Acne Vulgaris: A Review

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JAMA. 2021;326(20):2055-2067. doi:10.1001/jama.2021.17633

This review summarizes the characteristics of comedonal, inflammatory, and nodulocystic acne and describes current methods of treatment.

JAMA Guide to Statistics and Methods

Use of Confidence Intervals in Interpreting Nonstatistically Significant Results

Abstract Full Text
JAMA. 2021;326(20):2068-2069. doi:10.1001/jama.2021.16172

This Guide to Statistics and Methods describes how confidence intervals can be used to help in the interpretation of nonsignificant findings across all study designs.

JAMA Clinical Challenge

Back Pain, Fever, and Cough in a 46-Year-Old Man

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JAMA. 2021;326(20):2070-2071. doi:10.1001/jama.2021.17584

A 46-year-old man with a history of travel to India had 3 months of upper back pain and 2 weeks of dry cough and subjective fevers that did not improve with empirical azithromycin. Chest CT showed a dense consolidation in the left lower lobe; MRI showed a paraspinal mass with extensive contrast enhancement in the lower thoracic vertebral bodies and relative sparing of the disks. What is the diagnosis and what would you do next?

Medical News & Perspectives

Trials Test Mushrooms and Herbs as Anti–COVID-19 Agents

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JAMA. 2021;326(20):1997-1999. doi:10.1001/jama.2021.19388

This Medical News article describes trials that are examining whether medicinal mushrooms and Chinese herbs can improve treatment and vaccine responses against COVID-19.

News From the Food and Drug Administration

Compounded Drug Guidance for Hospital and Health System Pharmacies

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JAMA. 2021;326(20):2003. doi:10.1001/jama.2021.20539

New Clinical Trial Grants for Rare Diseases

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JAMA. 2021;326(20):2003. doi:10.1001/jama.2021.20256

First Thymus Tissue Product Approved for Rare Disease

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JAMA. 2021;326(20):2003. doi:10.1001/jama.2021.20538
News From the Centers for Disease Control and Prevention

COVID-19 Vaccine Highly Effective Against Adolescent Hospitalizations

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JAMA. 2021;326(20):2002. doi:10.1001/jama.2021.20143

Unhygienic Practices Lead to Routine Vaccination-Linked Infections

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JAMA. 2021;326(20):2002. doi:10.1001/jama.2021.20171
Clinical Trials Update

Pembrolizumab Boosts Breast and Cervical Cancer Survival

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JAMA. 2021;326(20):2001. doi:10.1001/jama.2021.19200

Daily COVID-19 Tests Compared With Isolation After School Exposure

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JAMA. 2021;326(20):2001. doi:10.1001/jama.2021.20471

Intensive Blood Pressure Control Lowers Cardiovascular Risk

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JAMA. 2021;326(20):2001. doi:10.1001/jama.2021.20472

Virtual Care Mitigates Pain and Drug Errors After Surgery

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JAMA. 2021;326(20):2001. doi:10.1001/jama.2021.20473
Health Agencies Update

Substance Use Disorders and COVID-19 Vaccine Response

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JAMA. 2021;326(20):2000. doi:10.1001/jama.2021.19977

Support for Primary Care Clinicians in Underserved Areas

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JAMA. 2021;326(20):2000. doi:10.1001/jama.2021.20454

The Cost of Rare Diseases

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JAMA. 2021;326(20):2000. doi:10.1001/jama.2021.20455
Poetry and Medicine

first death

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JAMA. 2021;326(20):2082. doi:10.1001/jama.2021.16531
JAMA Revisited

Bacterially Tainted Money

Abstract Full Text
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JAMA. 2021;326(20):2083. doi:10.1001/jama.2020.18242
JAMA Patient Page

Acne Treatment

Abstract Full Text
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JAMA. 2021;326(20):2087. doi:10.1001/jama.2021.16599

This JAMA Patient Page describes acne and the various forms of treatment for this skin condition.

Comment & Response

Risk of N-Nitrosodimethylamine (NMDA) Formation With Ranitidine

Abstract Full Text
JAMA. 2021;326(20):2077. doi:10.1001/jama.2021.16261

Risk of N-Nitrosodimethylamine (NMDA) Formation With Ranitidine—Reply

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JAMA. 2021;326(20):2077-2078. doi:10.1001/jama.2021.16264

The Role of Lipoprotein(a) in Cardiovascular Diseases

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JAMA. 2021;326(20):2078. doi:10.1001/jama.2021.16747

The Role of Lipoprotein(a) in Cardiovascular Diseases—Reply

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JAMA. 2021;326(20):2078-2079. doi:10.1001/jama.2021.16750

Effect of 7 vs 14 Days of Antibiotics Among Afebrile Men With Urinary Tract Infection

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JAMA. 2021;326(20):2079. doi:10.1001/jama.2021.16735

Effect of 7 vs 14 Days of Antibiotics Among Afebrile Men With Urinary Tract Infection

Abstract Full Text
JAMA. 2021;326(20):2079-2080. doi:10.1001/jama.2021.16741

Effect of 7 vs 14 Days of Antibiotics Among Afebrile Men With Urinary Tract Infection

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JAMA. 2021;326(20):2080. doi:10.1001/jama.2021.16738

Effect of 7 vs 14 Days of Antibiotics Among Afebrile Men With Urinary Tract Infection—Reply

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JAMA. 2021;326(20):2080-2081. doi:10.1001/jama.2021.16744
Correction

Error in Box

Abstract Full Text
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JAMA. 2021;326(20):2081. doi:10.1001/jama.2021.19984

Incorrect Laboratory Value and Reference

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JAMA. 2021;326(20):2081. doi:10.1001/jama.2021.20138
JAMA Masthead

JAMA

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JAMA. 2021;326(20):1995-1996. doi:10.1001/jama.2020.18239
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