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April 2021 - July 1883

Decade

Year

Issue

April 13, 2021, Vol 325, No. 14, Pages 1369-1480

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2021;325(14):e2017881. doi:10.1001/jama.2020.17881
Original Investigation

Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial

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JAMA. 2021;325(14):1403-1413. doi:10.1001/jama.2021.1831

This randomized clinical trial compares the effects of once-weekly subcutaneous semaglutide vs placebo for weight management as an adjunct to intensive behavioral therapy with initial low-calorie diet in adults with overweight or obesity.

Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial

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JAMA. 2021;325(14):1414-1425. doi:10.1001/jama.2021.3224

This randomized trial compares the effects of continuing weekly treatment with subcutaneous semaglutide vs switching to placebo on change in body weight over 48 weeks among adults with overweight or obesity who completed a 20-week run-in period with semaglutide.

Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial

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JAMA. 2021;325(14):1426-1435. doi:10.1001/jama.2021.3071

This randomized trial compares the effects of ivermectin vs placebo on time to symptom resolution within 21 days among patients with mild COVID-19.

Research Letter

Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2

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JAMA. 2021;325(14):1467-1469. doi:10.1001/jama.2021.3341

This study compares titers of binding and neutralizing antibodies after a single mRNA coronavirus vaccine dose in health care workers previously infected with SARS-CoV-2.

Discriminant Accuracy of the SOFA Score for Determining the Probable Mortality of Patients With COVID-19 Pneumonia Requiring Mechanical Ventilation

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JAMA. 2021;325(14):1469-1470. doi:10.1001/jama.2021.1545

This cohort study characterizes the accuracy of the Sequential Organ Failure Assessment (SOFA) score to discriminate death from survival in patients with COVID-19 pneumonia receiving oxygen therapy for 4 hours or longer before undergoing endotracheal intubation.

US Preventive Services Task Force

Recommendation Statement

Screening for Vitamin D Deficiency in Adults: US Preventive Services Task Force Recommendation Statement

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JAMA. 2021;325(14):1436-1442. doi:10.1001/jama.2021.3069

This 2021 US Preventive Services Task Force Recommendation Statement concludes that current evidence is insufficient to assess the balance of benefits and harms of screening for vitamin D deficiency in asymptomatic adults (I statement).

Evidence Report

Screening for Vitamin D Deficiency in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

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JAMA. 2021;325(14):1443-1463. doi:10.1001/jama.2020.26498

This systematic review to support the 2021 US Preventive Services Task Force Recommendation Statement on screening for vitamin D deficiency summarizes published evidence on the benefits and harms of screening and interventions for vitamin D deficiency in asymptomatic, community-dwelling adults.

Viewpoint

Health Policy

How the Biden Administration Can Improve Health Equity for Racial and Ethnic Minority Populations

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JAMA. 2021;325(14):1387-1388. doi:10.1001/jama.2021.3046

This Viewpoint outlines actions that the new federal administration could consider related to health care access and quality, and social determinants of health, to meaningfully improve health equity for racial/ethnic minority populations.

COVID-19 in 2021—Continuing Uncertainty

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JAMA. 2021;325(14):1389-1390. doi:10.1001/jama.2021.3760

This Viewpoint summarizes the current best evidence about COVID-19 vaccines, immunity, and whether SARS-CoV-2 will become an endemic or seasonal virus.

National Initiatives to Prevent Myocardial Infarction and Stroke

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JAMA. 2021;325(14):1391-1392. doi:10.1001/jama.2021.0905

This Viewpoint discusses the Million Hearts initiative, a national effort that aims to prevent a million myocardial infarctions and strokes over 5 years, and proposes actions and strategies federal agencies can take to advance tobacco control, sodium reduction, trans fat elimination, hypertension control, and centering the US health care system on primary care.

A Piece of My Mind

On Mentoring

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JAMA. 2021;325(14):1393. doi:10.1001/jama.2021.4070

In this narrative medicine essay, JAMA’s editor in chief remembers his career mentors and their selflessness as they guided him in his early and mid-career and later became friends and colleagues.

Editorial

The Near-Term Future of Health Care Reform

Abstract Full Text
JAMA. 2021;325(14):1394-1397. doi:10.1001/jama.2021.1472

Crucial Questions for US Health Policy in the Next Decade

Abstract Full Text
JAMA. 2021;325(14):1397-1399. doi:10.1001/jama.2021.1470

Confronting Challenges in the US Health Care System: Potential Opportunity in a Time of Crisis

Abstract Full Text
JAMA. 2021;325(14):1399-1400. doi:10.1001/jama.2021.1471

The USPSTF 2021 Recommendations on Screening for Asymptomatic Vitamin D Deficiency in Adults: The Challenge for Clinicians Continues

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JAMA. 2021;325(14):1401-1402. doi:10.1001/jama.2021.2227
JAMA Insights

Identifying COVID-19 Risk Through Observational Studies to Inform Control Measures

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JAMA. 2021;325(14):1464-1465. doi:10.1001/jama.2021.1995

This JAMA Insights Clinical Update from the CDC’s COVID-19 Response Team discusses the importance of observational data for identifying behaviors associated with SARS-CoV-2 transmission, and presents data suggesting that indoor eating or drinking poses the highest risk, presumably because of prolonged exposure to unmasked, non–physically distanced companions.

Medical News & Perspectives

How the US Failed to Prioritize SARS-CoV-2 Variant Surveillance

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JAMA. 2021;325(14):1380-1382. doi:10.1001/jama.2021.3368

This Medical News article discusses genomic sequencing to detect and track virus variants during the COVID-19 pandemic.

The JAMA Forum

Time to Rethink Nursing Homes

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JAMA. 2021;325(14):1383-1384. doi:10.1001/jama.2021.2567
News From the Centers for Disease Control and Prevention

COVID-19 Precautions Are Scarce in Non–Health Care Workplaces

Abstract Full Text
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JAMA. 2021;325(14):1386. doi:10.1001/jama.2021.4844

Disparities in Suicide Persist Despite Overall Dip in US Rate

Abstract Full Text
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JAMA. 2021;325(14):1386. doi:10.1001/jama.2021.4131
Biotech Innovations

Data Leak Exposes Early COVID-19 Vaccine Manufacturing Hiccups

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JAMA. 2021;325(14):1385. doi:10.1001/jama.2021.5002

Teplizumab Improves Beta Cell Function, Delays Type 1 Diabetes

Abstract Full Text
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JAMA. 2021;325(14):1385. doi:10.1001/jama.2021.4628

Wearable Bilirubin Measurement Device for Neonatal Jaundice

Abstract Full Text
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JAMA. 2021;325(14):1385. doi:10.1001/jama.2021.5004
The Arts and Medicine

COVID-19 Postage Stamps—Messages in a Message

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JAMA. 2021;325(14):1377-1379. doi:10.1001/jama.2021.2139

This Arts and Medicine feature presents global postage and commemorative stamps issued by countries and nongovernmental organizations in 2020 featuring coronavirus pandemic-related themes.

Poetry and Medicine

Winter of Fear

Abstract Full Text
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JAMA. 2021;325(14):1474. doi:10.1001/jama.2021.1609
JAMA Revisited

Neurology in Art

Abstract Full Text
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JAMA. 2021;325(14):1475. doi:10.1001/jama.2020.17882
JAMA Patient Page

Screening for Vitamin D Deficiency in Adults

Abstract Full Text
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JAMA. 2021;325(14):1480. doi:10.1001/jama.2021.4606

This JAMA Patient Page summarizes the US Preventive Services Task Force’s 2021 recommendation that current evidence is insufficient to assess the balance of benefits and harms of screening for vitamin D deficiency in asymptomatic adults (I statement).

Comment & Response

Effect of Early Recombinant Human Erythropoietin on Neurodevelopmental Outcomes at Age 5 Years

Abstract Full Text
JAMA. 2021;325(14):1470-1471. doi:10.1001/jama.2021.0833

Effect of Early Recombinant Human Erythropoietin on Neurodevelopmental Outcomes at Age 5 Years—Reply

Abstract Full Text
JAMA. 2021;325(14):1471-1472. doi:10.1001/jama.2021.0836

Review of Gastroesophageal Reflux Disease

Abstract Full Text
JAMA. 2021;325(14):1472. doi:10.1001/jama.2021.1438

Review of Gastroesophageal Reflux Disease—Reply

Abstract Full Text
JAMA. 2021;325(14):1472-1473. doi:10.1001/jama.2021.1444
Correction

Incorrect Values in Table

Abstract Full Text
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JAMA. 2021;325(14):1473. doi:10.1001/jama.2021.4108
JAMA Masthead

JAMA

Abstract Full Text
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JAMA. 2021;325(14):1369-1370. doi:10.1001/jama.2020.17879
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