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November 2018 - July 1883

Decade

Year

Issue

November 13, 2018, Vol 320, No. 18, Pages 1833-1948

In This Issue of JAMA

Highlights

Abstract Full Text
free access has audio
JAMA. 2018;320(18):1833-1835. doi:10.1001/jama.2017.12625
Viewpoint

Gadolinium Retention After Contrast-Enhanced MRI

Abstract Full Text
JAMA. 2018;320(18):1853-1854. doi:10.1001/jama.2018.13362

This Viewpoint discusses the retention of gadolinium, used in contrast-enhanced MRI, in skin and kidney tissue and the efforts of experts from radiological societies, the NIH, and the FDA to study the safety of this element in clinical use.

Using Quality Improvement to Promote Clinical Trials of Emergency Trauma Therapies

Abstract Full Text
JAMA. 2018;320(18):1855-1856. doi:10.1001/jama.2018.13607

This Viewpoint discusses the use of quality improvement reviews to build consensus about when randomized trials of competing treatment strategies are indicated and to inform the design and conduct of comparative effectiveness trials in emergency trauma.

Million Hearts 2022Small Steps Are Needed for Cardiovascular Disease Prevention

Abstract Full Text
JAMA. 2018;320(18):1857-1858. doi:10.1001/jama.2018.13326

This Viewpoint describes the Million Hearts initiative, a US Centers for Disease Control and Prevention (CDC) and Centers for Medicare & Medicaid Services program aimed at preventing 1 million acute cardiovascular (CV) events by improving key cardiovascular disease (CVD) risk factors, and summarizes two 2018 CDC reports describing the burden of preventable CVD deaths and the slow rate of improving population-level measures of CV health.

Group Purchasing Organizations, Health Care Costs, and Drug Shortages

Abstract Full Text
JAMA. 2018;320(18):1859-1860. doi:10.1001/jama.2018.13604

This Viewpoint explains how group purchasing organizations (GPOs) – companies that purchase devices, supplies, and medication from multiple manufacturers and serve as single supply sources for hospitals and medical centers – contribute to supply shortages, higher prices, and limited product selection, and proposes policy solutions to overcome the adverse effects of the arrangements.

A Piece of My Mind

Grief After Suicide

Abstract Full Text
free access
JAMA. 2018;320(18):1861-1862. doi:10.1001/jama.2018.15664

In this narrative medicine essay, the author mourns the suicide of young adult of a friend and relives his brother’s suicide 30 years earlier in a stream of consiousness montage of grief and advice to succor for those left behind.

Editorial

Lessons From ARDS for Non-ARDS ResearchRemembrance of Trials Past

Abstract Full Text
JAMA. 2018;320(18):1863-1865. doi:10.1001/jama.2018.14288

Weaning From Mechanical VentilationWhat Should Be Done When a Patient’s Spontaneous Breathing Trial Fails?

Abstract Full Text
JAMA. 2018;320(18):1865-1867. doi:10.1001/jama.2018.13762

Overcoming Inertia to Improve Medication Use and Deprescribing

Abstract Full Text
JAMA. 2018;320(18):1867-1869. doi:10.1001/jama.2018.16473

Screening for Unhealthy Alcohol Use

Abstract Full Text
free access
JAMA. 2018;320(18):1869-1871. doi:10.1001/jama.2018.16069
Original Investigation

Caring for the Critically Ill Patient

Effect of a Low vs Intermediate Tidal Volume Strategy on Ventilator-Free Days in Intensive Care Unit Patients Without ARDSA Randomized Clinical Trial

Abstract Full Text
has active quiz has audio
JAMA. 2018;320(18):1872-1880. doi:10.1001/jama.2018.14280

This randomized trial compares the effects of low vs intermediate tidal volumes on ventilator-free days and mortality among intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS).

Caring for the Critically Ill Patient

Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation From Mechanical Ventilation Among Patients With Respiratory FailureThe Breathe Randomized Clinical Trial

Abstract Full Text
JAMA. 2018;320(18):1881-1888. doi:10.1001/jama.2018.13763

This randomized trial compares the effects of protocolized weaning via early extubation to noninvasive ventilation vs standard weaning from invasive ventilation on time to liberation from mechanical ventilation among adults with respiratory failure ready to wean but with an unsuccessful spontaneous breathing trial.

Effect of a Pharmacist-Led Educational Intervention on Inappropriate Medication Prescriptions in Older AdultsThe D-PRESCRIBE Randomized Clinical Trial

Abstract Full Text
free access has active quiz has multimedia
JAMA. 2018;320(18):1889-1898. doi:10.1001/jama.2018.16131

This cluster randomized trial investigates the effects on medication discontinuation of a program in which pharmacists educated older patients taking benzodiazepines, sedative-hypnotics, first-generation antihistamines, and selective NSAIDs about why the drugs are inappropriate for their age groups and offered potential alternative treatment options.

US Preventive Services Task Force

Recommendation Statement

Screening and Behavioral Counseling Interventions to Reduce Unhealthy Alcohol Use in Adolescents and AdultsUS Preventive Services Task Force Recommendation Statement

Abstract Full Text
free access has active quiz has audio
JAMA. 2018;320(18):1899-1909. doi:10.1001/jama.2018.16789

This 2018 Recommendation Statement from the US Preventive Services Task Force recommends screening for unhealthy alcohol use in primary care settings in adults, including pregnant women, and providing brief behavioral counseling to reduce unhealthy alcohol use (B recommendation) and concludes that evidence is insufficient to assess balance of benefits and harms of screening and counseling for alcohol use in primary care settings in adolescents (I statement).

Evidence Report

Screening and Behavioral Counseling Interventions to Reduce Unhealthy Alcohol Use in Adolescents and AdultsUpdated Evidence Report and Systematic Review for the US Preventive Services Task Force

Abstract Full Text
free access
JAMA. 2018;320(18):1910-1928. doi:10.1001/jama.2018.12086

This systematic review to support the 2018 US Preventive Services Task Force Recommendation Statement on screening and behavioral counseling to reduce unhealthy alcohol use summarizes published evidence on the benefits and harms of screening and behavioral counseling to reduce unhealthy alcohol use among adults.

JAMA Insights

Distinguishing Variant Pathogenicity From Genetic DiagnosisHow to Know Whether a Variant Causes a Condition

Abstract Full Text
JAMA. 2018;320(18):1929-1930. doi:10.1001/jama.2018.14900

This Genomics and Precision Health article explains the use of genomic testing in clinical settings when a genetic basis for disease is suspected, but the evaluation has not provided enough specificity to guide selection of a single gene test or a gene panel test.

Research Letter

Provision of Naloxone Without a Prescription by California Pharmacists 2 Years After Legislation Implementation

Abstract Full Text
JAMA. 2018;320(18):1933-1934. doi:10.1001/jama.2018.12291

This study assesses the availability of pharmacist-furnished naloxone 2 years after implementation of legislation in California allowing provision of the drug without a physician’s prescription.

Naloxone Accessibility Without a Prescriber Encounter Under Standing Orders at Community Pharmacy Chains in Texas

Abstract Full Text
JAMA. 2018;320(18):1934-1937. doi:10.1001/jama.2018.15892

This study evaluated naloxone accessibility from chain pharmacies in Texas 32 months after state legislation allowing pharmacists to dispense naloxone under standing orders from authorizing prescribers.

Medical News & Perspectives

Overdiagnosis of Penicillin Allergy Leads to Costly, Inappropriate Treatment

Abstract Full Text
free access
JAMA. 2018;320(18):1846-1848. doi:10.1001/jama.2018.14358

This Medical News article discusses why many patients have mistakenly been labeled as allergic to penicillin and the impact that can have on their health.

Is There a Seasonal Influence on Cognition and Dementia?

Abstract Full Text
free access
JAMA. 2018;320(18):1848-1849. doi:10.1001/jama.2018.16286

This Medical News article discusses a recently discovered association between time of year and cognitive performance even in people with Alzheimer disease.

News From the Centers for Disease Control and Prevention

Antibiotic Resistance Challenge

Abstract Full Text
free access
JAMA. 2018;320(18):1851. doi:10.1001/jama.2018.16587

Alzheimer Burden

Abstract Full Text
free access
JAMA. 2018;320(18):1851. doi:10.1001/jama.2018.16787
Biotech Innovations

Recovery of Voluntary Movement After Paralysis

Abstract Full Text
free access
JAMA. 2018;320(18):1850. doi:10.1001/jama.2018.17584

Device Reduces Heart Failure Hospitalizations and Deaths

Abstract Full Text
free access
JAMA. 2018;320(18):1850. doi:10.1001/jama.2018.17020

Relapses After CAR-T Therapy

Abstract Full Text
free access
JAMA. 2018;320(18):1850. doi:10.1001/jama.2018.17585
Comment & Response

Guidelines on Glycemic Targets for Persons With Type 2 Diabetes

Abstract Full Text
JAMA. 2018;320(18):1937. doi:10.1001/jama.2018.13417

Guidelines on Glycemic Targets for Persons With Type 2 Diabetes—Reply

Abstract Full Text
JAMA. 2018;320(18):1937-1938. doi:10.1001/jama.2018.13421

Methods of Screening for Cervical Cancer

Abstract Full Text
JAMA. 2018;320(18):1938-1939. doi:10.1001/jama.2018.13939

Methods of Screening for Cervical Cancer—Reply

Abstract Full Text
JAMA. 2018;320(18):1939. doi:10.1001/jama.2018.13943

Injection Drug Use–Associated Infective Endocarditis

Abstract Full Text
JAMA. 2018;320(18):1939. doi:10.1001/jama.2018.14071

Injection Drug Use-Associated Infective Endocarditis—Reply

Abstract Full Text
JAMA. 2018;320(18):1939-1940. doi:10.1001/jama.2018.14075
Correction

Minor Errors to Power Calculation Information

Abstract Full Text
free access
JAMA. 2018;320(18):1940. doi:10.1001/jama.2018.17363
Poetry and Medicine

The Surgery

Abstract Full Text
free access
JAMA. 2018;320(18):1942. doi:10.1001/jama.2018.8747
JAMA Revisited

No Intimations as Yet

Abstract Full Text
JAMA. 2018;320(18):1943. doi:10.1001/jama.2017.12655
JAMA Patient Page

Screening and Counseling to Reduce Unhealthy Alcohol Use

Abstract Full Text
free access
JAMA. 2018;320(18):1948. doi:10.1001/jama.2018.16735

This JAMA Patient Page describes the US Preventive Services Task Force’s recent recommendations on screening and counseling to reduce unhealthy alcohol use.

JAMA Masthead

JAMA

Abstract Full Text
free access
JAMA. 2018;320(18):1837-1838. doi:10.1001/jama.2017.12626
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