This clinical trial compares the effect of 3 management strategies on successful resolution of pregnancy among patients with a persisting pregnancy of unknown location.
This cluster randomized clinical trial compares a sedation and ventilator liberation protocol intervention for the duration of invasive mechanical ventilation vs usual care in infants and children anticipated to require prolonged mechanical ventilation.
This study examines whether there are associations between opioid dose tapering and subsequent rates of overdose and mental health crisis among patients prescribed stable, long-term, high-dose opioids.
This study uses Medicare claims data to compare spending for hip and joint replacements among hospitals with voluntary vs mandatory participation vs nonparticipation in the Medicare Bundled Payments for Care Improvement program between 2011 and 2017.
This Special Communication reviews the development of laws and standards affecting the evaluation and oversight of medical devices by the US Food and Drug Administration (FDA) and the outcomes of this regulatory system from 1976 to 2020.
This Viewpoint proposes several important areas of surveillance expansion by US public health agencies and other institutions for COVID-19 testing, vaccination, infection, and mortality rates.
This Viewpoint discusses the recently approved drug aducanumab as a treatment for Alzheimer disease and whether it might be covered under Medicare, a decision made by CMS administrators.
This Viewpoint describes 5 lessons learned from implementation of the HITECH Act that apply to the modernization of public health data for the COVID-19 era and beyond.
In this narrative medicine essay, a geriatrician muses about his 44-year relationship with his pager, describes its changes in sound and form, and compares it with its smartphone replacement, which he deems is more functional and more frightening.
This JAMA Guide to Statistics and Methods describes how intention-to-treat, per-protocol, and as-treated approaches to analysis differ with regard to the patient population and treatment assignments and their implications for interpretation of treatment effects in clinical trials.
A 36-year-old man with a history of chronic HIV infection had 3 weeks of generalized weakness; examination revealed a maculopapular rash on his arms and torso and patchy hair loss on his scalp. His CD4+ cell count was 820/μL and his HIV viral load was undetectable. What is the diagnosis and what would you do next?
This Medical News article discusses the duration of immunity after SARS-CoV-2 infection.
This JAMA Patient Page describes the types of nonpharmacologic and pharmacologic approaches available for pain management during vaginal childbirth.
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