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July 2021 - July 1883

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Issue

July 20, 2021, Vol 326, No. 3, Pages 207-286

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2021;326(3):e2018037. doi:10.1001/jama.2020.18037
Original Investigation

Effect of Canakinumab vs Placebo on Survival Without Invasive Mechanical Ventilation in Patients Hospitalized With Severe COVID-19: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2021;326(3):230-239. doi:10.1001/jama.2021.9508

This clinical trial compares the efficacy of canakinumab vs placebo on survival without invasive mechanical ventilation (IMV) in patients hospitalized with severe COVID-19.

Effect of Oral Ranitidine on Urinary Excretion of N-Nitrosodimethylamine (NDMA): A Randomized Clinical Trial

Abstract Full Text
JAMA. 2021;326(3):240-249. doi:10.1001/jama.2021.9199

This phase 1 randomized crossover clinical trial evaluates the 24-hour urinary excretion of N-nitrosodimethylamine (NDMA) after oral administration of ranitidine compared with placebo.

Medical Debt in the US, 2009-2020

Abstract Full Text
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JAMA. 2021;326(3):250-256. doi:10.1001/jama.2021.8694

This retrospective cohort analysis of credit reports for a nationally representative 10% panel of individuals estimates the amount of medical debt nationally and by geographic region and income group and its association with Medicaid expansion under the Affordable Care Act.

Research Letter

Sperm Parameters Before and After COVID-19 mRNA Vaccination

Abstract Full Text
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JAMA. 2021;326(3):273-274. doi:10.1001/jama.2021.9976

To address vaccine hesitancy based on concerns about fertility, this study assesses sperm parameters before and after mRNA vaccine administration.

Prescription Drug Monitoring Program Mandates and Opioids Dispensed Following Emergency Department Encounters for Patients With Sickle Cell Disease or Cancer With Bone Metastasis

Abstract Full Text
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JAMA. 2021;326(3):274-276. doi:10.1001/jama.2021.10161

This study examines the association between prescription drug monitoring program mandates and changes in opioids dispensed to patients with sickle cell disease or cancer with bone metastasis who presented to the emergency department in 29 US states.

Special Communication

Guidelines for Reporting Trial Protocols and Completed Trials Modified Due to the COVID-19 Pandemic and Other Extenuating Circumstances: The CONSERVE 2021 Statement

Abstract Full Text
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JAMA. 2021;326(3):257-265. doi:10.1001/jama.2021.9941

This Special Communication describes CONSERVE, a guideline developed to improve the transparency, quality, and completeness of reporting of trials and trial protocols that undergo important modifications in response to extenuating circumstances such as the COVID-19 pandemic.

Viewpoint

Intensive Medical Management to Prevent Large and Small Artery Atherothrombotic Stroke: Time to Expand the Horizon

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JAMA. 2021;326(3):217-218. doi:10.1001/jama.2021.9917

This Viewpoint examines the potential of using newer strategies to prevent ischemic stroke due to large and small artery atherothrombosis, including agents to lower LDL cholesterol, as well as increase eicosapentaenoic acid levels, insulin sensitivity and synthesis, and folic acid levels.

Sharing Technology and Vaccine Doses to Address Global Vaccine Inequity and End the COVID-19 Pandemic

Abstract Full Text
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JAMA. 2021;326(3):219-220. doi:10.1001/jama.2021.10823

This Viewpoint offers 3 strategies to address inequity in pandemic vaccine response: surge funding, increased funding, and an agreement to share technology and allow countries to waive intellectual property rights in global public health emergencies.

Ethical Considerations of Offering Benefits to COVID-19 Vaccine Recipients

Abstract Full Text
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JAMA. 2021;326(3):221-222. doi:10.1001/jama.2021.11045

This Viewpoint discusses why offering incentives for COVID-19 vaccination is not only ethical, but an important tool in increasing vaccine uptake, which benefits society as a whole.

A Piece of My Mind

To Err Is Human, to Apologize Is Hard

Abstract Full Text
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JAMA. 2021;326(3):223-224. doi:10.1001/jama.2021.10840

In this narrative medicine essay, an internist asks the doctors who for 5 months could not diagnose her son’s agonizing illness to apologize and, when most could not, asks that the medical community shift focus from promoting a false sense of perfection to one that embraces humility enough to apologize as essential to the healing process.

Editorial

Ranitidine and Risk of N-Nitrosodimethylamine (NDMA) Formation

Abstract Full Text
JAMA. 2021;326(3):225-227. doi:10.1001/jama.2021.10043

Medical Debt as a Social Determinant of Health

Abstract Full Text
JAMA. 2021;326(3):228-229. doi:10.1001/jama.2021.9011
JAMA Insights

Clinical Update

Novel Lipid-Lowering Therapies to Reduce Cardiovascular Risk

Abstract Full Text
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JAMA. 2021;326(3):266-267. doi:10.1001/jama.2021.2244

This JAMA Insights Clinical Update reviews lipid-lowering therapies prescribed to reduce cardiovascular risk, including statins and ezetimibe, as well as novel therapies such as PCSK-9 inhibitors, bempedoic acid, icosapent ethyl, and inclisiran.

Genomics and Precision Health

Challenges of Accuracy in Germline Clinical Sequencing Data

Abstract Full Text
JAMA. 2021;326(3):268-269. doi:10.1001/jama.2021.0407

This Genomics and Precision Health article explains how genetic testing has evolved from detection of prespecified and unknown variants to assessing entire genomes to establish diagnoses using high-throughput sequencing.

From The Medical Letter on Drugs and Therapeutics

Metoclopramide Nasal Spray (Gimoti) for Diabetic Gastroparesis

Abstract Full Text
JAMA. 2021;326(3):270-271. doi:10.1001/jama.2020.26625

This Medical Letter review summarizes the use of Gimoti, a nasal spray formulation of the dopamine-2 receptor antagonist metoclopramide, for relief of symptoms in adults with acute and recurrent diabetic gastroparesis.

Medical News & Perspectives

Alcohol-Related Diseases Increased as Some People Drank More During the COVID-19 Pandemic

Abstract Full Text
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JAMA. 2021;326(3):209-211. doi:10.1001/jama.2021.10626

This Medical News feature examines the association between changes in alcohol use patterns during the pandemic and increases in alcohol-associated diseases.

Another COVID-19 Fallout: Teens’ Happy Hour With Parents

Abstract Full Text
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JAMA. 2021;326(3):212-213. doi:10.1001/jama.2021.11007

This Medical News article discusses parents’ decisions to permit their teenage children to drink alcohol during COVID-19 shutdowns and the effect alcohol has on brain development during adolescence.

News From the Food and Drug Administration

FDA: Stop Using Medtronic’s Heartware Ventricular Assist Device

Abstract Full Text
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JAMA. 2021;326(3):215. doi:10.1001/jama.2021.11386

New Software Can Aid in Early Autism Spectrum Disorder Diagnosis

Abstract Full Text
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JAMA. 2021;326(3):215. doi:10.1001/jama.2021.10699

Treatment Approved for “Undruggable” Lung Cancer

Abstract Full Text
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JAMA. 2021;326(3):215. doi:10.1001/jama.2021.11387
Global Health

Antibiotic Use in UK’s COVID-19 Patients Often Unnecessary

Abstract Full Text
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JAMA. 2021;326(3):214. doi:10.1001/jama.2021.10458

Urgent Need to Reduce Heart Disease Among Women Worldwide

Abstract Full Text
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JAMA. 2021;326(3):214. doi:10.1001/jama.2021.11409

Patients in Afghanistan Face Growing Obstacles to Care

Abstract Full Text
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JAMA. 2021;326(3):214. doi:10.1001/jama.2021.11410
Poetry and Medicine

Javits Center

Abstract Full Text
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JAMA. 2021;326(3):281. doi:10.1001/jama.2021.8039
JAMA Revisited

Current Comment

Abstract Full Text
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JAMA. 2021;326(3):282. doi:10.1001/jama.2020.18038
JAMA Patient Page

Low Back Pain

Abstract Full Text
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JAMA. 2021;326(3):286. doi:10.1001/jama.2020.19715

This JAMA Patient Page describes low back pain and its diagnosis and treatment options.

Comment & Response

Backstop Price Caps in Commercial Health Care Markets

Abstract Full Text
JAMA. 2021;326(3):276-277. doi:10.1001/jama.2021.6809

Backstop Price Caps in Commercial Health Care Markets—Reply

Abstract Full Text
JAMA. 2021;326(3):277. doi:10.1001/jama.2021.6812

Strategies to Overcome the Market Dominance of Hospitals

Abstract Full Text
JAMA. 2021;326(3):277-278. doi:10.1001/jama.2021.6892

Strategies to Overcome the Market Dominance of Hospitals—Reply

Abstract Full Text
JAMA. 2021;326(3):278-279. doi:10.1001/jama.2021.6895
Correction

Addition of Nonauthor Collaborator Names of the WHIST Trial

Abstract Full Text
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JAMA. 2021;326(3):279. doi:10.1001/jama.2021.7433

Incorrect Terminology

Abstract Full Text
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JAMA. 2021;326(3):279. doi:10.1001/jama.2021.10417

Incorrect Labels in Figure

Abstract Full Text
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JAMA. 2021;326(3):279. doi:10.1001/jama.2021.10237
JAMA Masthead

JAMA

Abstract Full Text
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JAMA. 2021;326(3):207-208. doi:10.1001/jama.2020.18035
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