Calhoun and coauthors compared physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma in the Best Adjustment Strategy for Asthma in the Long Term (BASALT) randomized controlled trial. In an accompanying Editorial, Reibman and O’Connor discuss inhaled corticosteroid dose adjustment in mild persistent asthma.
In a comparison of 4 national French registries of a single month for the years 1995, 2000, 2005, and 2010, Danchin and coauthors tracked survival rates among patients with ST-elevation myocardial infarction to determine whether factors other than reperfusion therapy contributed to improved survival rates.
Stoffels and coauthors compared metastatic node detection and disease-free survival using single-photon emission computed tomography/computed tomography-aided sentinel lymph node excision (SLNE) vs standard SLNE in 464 patients with melanoma from a single institution.
Colla and coauthors compared spending and outcomes between 10 practices participating in the Medicare Physician Group Practice Demonstration (n = 990 177) and local control practices (n = 7 514 453) before and during the demonstration using different risk adjustment. In an editorial Berwick discusses how the findings may inform new models of care.
Rizos and colleagues performed a systematic review and meta-analysis of randomized clinical trials evaluating the effect of omega-3 polyunsaturated fatty acids on major cardiovascular outcomes. Twenty studies of 68 680 patients were included, reporting 7044 deaths, 3993 cardiac deaths, 1150 sudden deaths, 1837 myocardial infarctions, and 1490 strokes.
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