Nondystrophic myotonias (NDMs) are rare diseases caused by mutations in skeletal muscle ion channels. To determine the effects of mexiletine for symptoms and signs of myotonia in NDMs, Statland and coauthors assessed 59 patients at 7 neuromuscular referral centers in 4 countries. See related Editorial by Hoffman.
Murdoch and coauthors conducted an 18-month randomized controlled trial of 322 healthy adults in New Zealand to determine the effect of vitamin D3 supplementation on incidence and severity of upper respiratory tract infections. In an editorial, Linder discusses vitamin D and its relationship to respiratory
Bangalore and coauthors for the REACH Registry Investigators conducted a longitudinal, observational study of β-blocker use and clinical outcomes in stable patients with and without coronary artery disease in the Reduction of Atherothrombosis for Continued Health (REACH) registry.
To estimate risks for venous thromboembolism and the relation of these risks to disease duration and hospitalization in patients with rheumatoid arthritis (RA), Holmqvist and coauthors conducted a prospective, population-based cohort study among 37 856 patients with prevalent RA, 7904 with incident RA, and matched comparison cohorts drawn from the general population.
Shah discusses World Health Organization categories of pulmonary hypertension, a common syndrome that can represent a diagnostic and treatment dilemma. He outlines treatment strategies that exist in addition to pulmonary vasodilator therapy. An accompanying interactive supplement demonstrates transthoracic echocardiographic findings from 3 patients across the spectrum of pulmonary hypertension.
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