Fergusson and coauthors conducted a double-blind, randomized controlled trial in 377 premature, very low-birth-weight infants admitted to Canadian neonatal ICUs to determine if transfusion with red blood cells stored for 7 days or less decreased rates of major nosocomial infection and organ dysfunction.
In a case-crossover study involving 104 boys whose moderate or severe hemophilia was treated at 1 of 3 pediatric hemophilia centers in Australia, Broderick and coauthors assessed the magnitude of risk that physical activity imposes on bleeding episodes. In an editorial Manco-Johnson discusses plasma factor activity and reduced bleeding risk.
To determine if public reporting of percutaneous coronary intervention (PCI) outcomes is associated with lower PCI rates or higher mortality rates, Joynt and coauthors assessed data from fee-for-service Medicare patients (49 660 from reporting states and 48 142 from nonreporting states) hospitalized with acute myocardial infarction. In the related Editorial, Moscucci discusses public reporting of PCI outcomes.
In a population-based study of 4632 participants involving baseline examinations to 15.7 years of follow-up, Melander and coauthors examined the association between the hormone proneurotensin and the development of diabetes, cardiovascular disease (CVD), breast cancer, and mortality.
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