Ross D. Zafonte, DO; Emilia Bagiella, PhD; Beth M. Ansel, PhD; et al.
To determine the ability of citicoline to positively affect functional and cognitive status in persons with complicated mild, moderate, and severe traumatic brain injury (TBI), Zafonte and coauthors randomized 1213 patients with TBI to receive a 90-day regimen of citicoline or placebo. In the related Editorial, Ruff and Riechers discuss the importance of studies of TBI treatment.