To determine whether adjuvant chemotherapy improves survival for patients with periampullary adenocarcinomas, Neoptolemos and colleagues compared folinic acid plus fluorouracil and gemcitabine with observation in a phase 3 trial by randomly assigning 428 patients into 1 of the 3 groups.
To assess efficacy and safety of perioperative acadesine in reducing morbidity and mortality associated with coronary artery bypass graft surgery, Newman and coauthors randomly assigned 3080 intermediate- to high-risk patients to receive acadesine or placebo.
In a registry-based cohort study of all liveborn singleton infants delivered in Denmark (November 2, 2009-September 30, 2010; N= 53 432), Pasternak and coauthors assess whether prenatal exposure to adjuvanted influenza A(H1N1)pdm09 vaccine is associated with increased risk of adverse fetal outcomes.
De Wals and coauthors used immunization registry, hospital discharge database, and census data to ascertain whether vaccination against 2009 influenza A(H1N1) during the swine flu pandemic was associated with cases of Guillain-Barré syndrome in the population of Quebec.
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