Sullivan and coauthors conducted a trial for patients with statin intolerance to assess the efficacy and tolerability of a human monoclonal antibody to PCSK9 (plasma proprotein convertase subtilisin/kexin type 9). The 12-week, randomized, double-blind, placebo- and ezetimibe-controlled, dose-ranging study was conducted between July 2011 and May 2012.
To examine the association of regular aspirin use with incidence of age-related macular degeneration, Klein and coauthors conducted a longitudinal (20 years) population-based study of age-related eye diseases among 4926 adult patients.
Li and coauthors report on the association between exposure to the destruction of the World Trade Center and excess cancer risk from 2003 through 2008.
Gregg and coauthors conducted an ancillary analysis of the Look AHEAD randomized controlled trial to examine the association of a long-term weight loss intervention with remission of type 2 diabetes in 4503 overweight US adults.
In a meta-analysis of 15 trials that involved 37 814 patients with acute coronary syndromes and stable coronary artery disease, Bellemain-Appaix and coauthors evaluated the effect of clopidogrel pretreatment compared with no treatment on mortality and major bleeding after percutaneous coronary intervention.