March 27, 2013, Vol 309, No. 12, Pages 1201-1306

This Week in JAMA

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JAMA. 2013;309(12):1201. doi:10.1001/jama.2012.145324

Audio Editors' Summary: Effects of chelation therapy after AMI, effects of maintenance antibiotic therapy for bronchiectasis, effects of sildenafil for HFPEF, and more.

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A Systematic Plan for Firearms Law Reform

Katherine L. Record, JD, MPH, MA; Lawrence O. Gostin, JD

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JAMA. 2013;309(12):1231-1232. doi:10.1001/jama.2013.1127

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Mental Illness and New Gun Law Reforms: The Promise and Peril of Crisis-Driven Policy

Jeffrey Swanson, PhD

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JAMA. 2013;309(12):1233-1234. doi:10.1001/jama.2013.1113

The Economics of Genomic Medicine: Insights From the IOM Roundtable on Translating Genomic-Based Research for Health

W. Gregory Feero, MD, PhD; Catherine Wicklund, MS, CGC; David L. Veenstra, PharmD, PhD

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JAMA. 2013;309(12):1235-1236. doi:10.1001/jama.2013.113

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Crossing the Omic Chasm: A Time for Omic Ancillary Systems

Justin Starren, MD, PhD; Marc S. Williams, MD; Erwin P. Bottinger, MD

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JAMA. 2013;309(12):1237-1238. doi:10.1001/jama.2013.1579

A Piece of My Mind

The NRA Let Me Down

Paul Kettl, MD, MHA

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JAMA. 2013;309(12):1239-1240. doi:10.1001/jama.2013.1302

Original Contribution

Effect of Disodium EDTA Chelation Regimen on Cardiovascular Events in Patients With Previous Myocardial Infarction: The TACT Randomized Trial

Gervasio A. Lamas, MD; Christine Goertz, DC, PhD; Robin Boineau, MD, MA; et al.

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JAMA. 2013;309(12):1241-1250. doi:10.1001/jama.2013.2107

Lamas et al report results of the Trial to Assess Chelation Therapy (TACT), a randomized controlled trial analyzing whether EDTA-based chelation therapy reduced cardiovascular events in 1708 patients with a history of myocardial infarction. In editorials, Nissen and Bauchner et al discuss the evaluation of TACT.

Audio Author Interview: Effect of Disodium EDTA Chelation Regimen on Cardiovascular Events in Patients With Previous Myocardial Infarction: The TACT Randomized Trial

Editorial
Concerns About Reliability in the Trial to Assess Chelation Therapy (TACT)
Steven E. Nissen, MD
Evaluation of the Trial to Assess Chelation Therapy (TACT): The Scientific Process, Peer Review, and Editorial Scrutiny
Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA; Robert M. Golub, MD

Effect of Azithromycin Maintenance Treatment on Infectious Exacerbations Among Patients With Non–Cystic Fibrosis Bronchiectasis: The BAT Randomized Controlled Trial

Josje Altenburg, MD; Casper S. de Graaff, MD; Ymkje Stienstra, MD, PhD, MSc; et al.

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JAMA. 2013;309(12):1251-1259. doi:10.1001/jama.2013.1937

To determine the efficacy of macrolide maintenance treatment for adults with non–cystic fibrosis bronchiectasis, Altenburg and coauthors randomized 83 outpatients with 3 or more lower respiratory tract infections in the preceding year to receive azithromycin or placebo for 12 months. Elborn and Tunney provide comment in the related Editorial.

Editorial
Macrolides and Bronchiectasis: Clinical Benefit With a Resistance Price
J. Stuart Elborn, MD; Michael M. Tunney, PhD

Effect of Long-term, Low-Dose Erythromycin on Pulmonary Exacerbations Among Patients With Non–Cystic Fibrosis Bronchiectasis: The BLESS Randomized Controlled Trial

David J. Serisier, MBBS, DM, FRACP; Megan L. Martin, BN; Michael A. McGuckin, BSc, PhD; et al.

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JAMA. 2013;309(12):1260-1267. doi:10.1001/jama.2013.2290

Serisier and coauthors evaluate the clinical efficacy and antimicrobial resistance cost of low-dose erythromycin for patients with non–cystic fibrosis bronchiectasis in a 12-month, double-blind, placebo-controlled trial. In an Editorial, Elborn and Tunney discuss long-term macrolide therapy for patients with bronchiectasis.

Editorial
Macrolides and Bronchiectasis: Clinical Benefit With a Resistance Price
J. Stuart Elborn, MD; Michael M. Tunney, PhD

ONLINE FIRST

Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial

Margaret M. Redfield, MD; Horng H. Chen, MD; Barry A. Borlaug, MD; et al.

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JAMA. 2013;309(12):1268-1277. doi:10.1001/jama.2013.2024

To determine the effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction, Redfield and coauthors conducted a trial of 216 patients randomized to sildenafil or placebo and measured peak oxygen consumption along with a variety of clinical status variables.

Editorial

Evaluation of the Trial to Assess Chelation Therapy (TACT): The Scientific Process, Peer Review, and Editorial Scrutiny

Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA; Robert M. Golub, MD

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JAMA. 2013;309(12):1291-1292. doi:10.1001/jama.2013.2761

Editorial
Concerns About Reliability in the Trial to Assess Chelation Therapy (TACT)
Steven E. Nissen, MD

Concerns About Reliability in the Trial to Assess Chelation Therapy (TACT)

Steven E. Nissen, MD

Abstract Full Text

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JAMA. 2013;309(12):1293-1294. doi:10.1001/jama.2013.2778

Editorial
Evaluation of the Trial to Assess Chelation Therapy (TACT): The Scientific Process, Peer Review, and Editorial Scrutiny
Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA; Robert M. Golub, MD

Macrolides and Bronchiectasis: Clinical Benefit With a Resistance Price

J. Stuart Elborn, MD; Michael M. Tunney, PhD

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JAMA. 2013;309(12):1295-1296. doi:10.1001/jama.2013.2780

Is Sublingual Immunotherapy Ready for Use in the United States?

Harold S. Nelson, MD

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JAMA. 2013;309(12):1297-1298. doi:10.1001/jama.2013.2739

JAMA Clinical Challenge

Clinician's Corner

A 51-Year-Old Man With HIV and Cervicodorsal Lipodystrophy (Buffalo Hump)

Sachin M. Shridharani, MD; Raja Mohan, MD

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JAMA. 2013;309(12):1289-1290. doi:10.1001/jama.2013.2552

Medical News & Perspectives

After 50 Years, Newborn Screening Continues to Yield Public Health Gains

Bridget M. Kuehn, MSJ

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JAMA. 2013;309(12):1215-1217. doi:10.1001/jama.2013.2087

Studies Probe Restoring Speech in Persons With Chronic Stroke-Related Aphasia

Anita Slomski

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JAMA. 2013;309(12):1217-1218. doi:10.1001/jama.2013.1253

Visualizing Health Policy

Medicaid Expansion Under the Affordable Care Act

Kaiser Family Foundation*

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JAMA. 2013;309(12):1219. doi:10.1001/jama.2013.2481

News From the Centers for Disease Control and Prevention

CDC Grand Rounds: The Million Hearts Initiative

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JAMA. 2013;309(12):1221-1223. doi:10.1001/jama.2013.221

QuickStats: Drug-Poisoning Death Rates—National Vital Statistics System, United States, 2010

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JAMA. 2013;309(12):1224. doi:

Notes from the Field: Serogroup C Invasive Meningococcal Disease Among Men Who Have Sex With Men—New York City, 2010-2012

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JAMA. 2013;309(12):1224. doi:10.1001/jama.2013.109

Health Agencies Update

Fungal Infection in Florida

Bridget M. Kuehn, MSJ

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JAMA. 2013;309(12):1220. doi:10.1001/jama.2013.2584

Retinal Implant

Bridget M. Kuehn, MSJ

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JAMA. 2013;309(12):1220. doi:10.1001/jama.2013.2714

Teens and Substance Use

Bridget M. Kuehn, MSJ

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JAMA. 2013;309(12):1220. doi:10.1001/jama.2013.2716

Glucose During Pregnancy

Bridget M. Kuehn, MSJ

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JAMA. 2013;309(12):1220. doi:10.1001/jama.2013.2718

Letters

Warfarin Treatment After Bioprosthetic Aortic Valve Replacement

Hadi Daood Toeg, MD; Lise M. Bjerre, MD, PhD; Marc Ruel, MD, MPH

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JAMA. 2013;309(12):1225-1226. doi:10.1001/jama.2013.1972

Warfarin Treatment After Bioprosthetic Aortic Valve Replacement—Reply

Charlotte Mérie, MD; Lars Køber, MD, DMSc; Christian Torp-Pedersen, MD, DMSc

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JAMA. 2013;309(12):1225-1226. doi:10.1001/jama.2013.1978

Aspirin Use and Risk of Macular Degeneration

Mohammad H. Nowroozzadeh, MD

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JAMA. 2013;309(12):1226. doi:10.1001/jama.2013.2038

Aspirin Use and Risk of Macular Degeneration

Xinqian Hu, MM; Shibo Tang, MD, PhD

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JAMA. 2013;309(12):1227-1228. doi:10.1001/jama.2013.2035

Aspirin Use and Risk of Macular Degeneration—Reply

Barbara E. K. Klein, MD, MPH; Kerri P. Howard, MS

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JAMA. 2013;309(12):1227-1228. doi:10.1001/jama.2013.2041

Funding for Biomedical Research

Gordon H. Sun, MD, MS; Jeffrey D. Steinberg, PhD; Reshma Jagsi, MD, DPhil

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JAMA. 2013;309(12):1228-1229. doi:10.1001/jama.2013.1331

Funding for Biomedical Research—Reply

Hamilton Moses, MD; E. Ray Dorsey, MD, MBA

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JAMA. 2013;309(12):1228-1229. doi:10.1001/jama.2013.1346

The Cover

Easter Sunday

Jeanette M. Smith, MD

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JAMA. 2013;309(12):1205. doi:10.1001/jama.2012.176795

Poetry and Medicine

Virtual White Coat

Adam Possner, MD

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JAMA. 2013;309(12):1206. doi:10.1001/jama.2012.71220

JAMA Patient Page

Treatment of Varicose Veins

Allen Hamdan, MD; Edward H. Livingston, MD; Cassio Lynm, MA

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JAMA. 2013;309(12):1306. doi:10.1001/jama.2013.1704

Correction

Incorrect Address in: Incidence of Breast Cancer With Distant Involvement Among Women in the United States, 1976-2009

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JAMA. 2013;309(12):1229. doi:10.1001/jama.2013.2391

Data Errors in: Association of Hydroxyethyl Starch Administration with Mortality and Acute Kidney Injury in Critically Ill Patients Requiring Volume Resuscitation: A Systematic Review and Meta-analysis

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JAMA. 2013;309(12):1229. doi:10.1001/jama.2013.2529

Data Error and Expanded Explanation in: Warfarin After Bioprosthetic Aortic Valve Implantation

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JAMA. 2013;309(12):1229. doi:10.1001/jama.2013.2856

Editorial
Warfarin After Bioprosthetic Aortic Valve Implantation
Shamir R. Mehta, MD, MSc; Jeffrey I. Weitz, MD

Clinical Review

Sublingual Immunotherapy for the Treatment of Allergic Rhinoconjunctivitis and Asthma: A Systematic Review

Sandra Y. Lin, MD; Nkiruka Erekosima, MD, MPH; Julia M. Kim, MD, MPH; et al.

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JAMA. 2013;309(12):1278-1288. doi:10.1001/jama.2013.2049

Lin and coauthors report on the use of sublingual immunotherapy as a treatment for allergic rhinoconjunctivitis and asthma. In an accompanying Editorial, Nelson discusses whether sublingual immuotherapy is ready for use in the United States.

Editorial
Is Sublingual Immunotherapy Ready for Use in the United States?
Harold S. Nelson, MD

JAMA 100 Years Ago

THE RATTLESNAKE-VENOM TREATMENT OF EPILEPSY

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JAMA. 2013;309(12):1207. doi:10.1001/jama.2012.145314

May 2023 - July 1883

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