May 8, 2013, Vol 309, No. 18, Pages 1857-1948

In a randomized clinical trial of 1902 patients receiving implantable cardioverterdefibrillators, Gasparini and coauthors evaluated using a long detection vs standard detection interval during spontaneous ventricular tachyarrhythmias to reduce antitachycardia pacing and shock delivery.

To identify genetic loci associated with H pylori seroprevalence and determine the pathophysiological role of these loci, Mayerle and coauthors performed a metaanalysis of genome-wide association studies conducted in population-based cohorts, with subsequent whole-blood transcriptome analyses conducted in independent cohorts from the same populations. El-Omar provides comment in the related Editorial.

Mitsnefes and coauthors investigated the change in mortality rates over time among children and adolescents with end-stage kidney disease who initiated treatment with dialysis between 1990 and 2010. Using data from the United States Renal Data System, they performed a retrospective cohort study involving 23 401 individuals who initiated treatment at younger than 21 years.