Jörg D. Leuppi, MD, PhD; Philipp Schuetz, MD; Roland Bingisser, MD; et al.
In REDUCE (Reduction in the Use of Corticosteroids in Exacerbated COPD), a randomized, noninferiority multicenter trial, Leuppi and coauthors investigate whether a short-term systemic glucocorticoid treatment in patients with COPD exacerbation is noninferior to conventional treatment with respect to clinical outcome, and whether it decreases the exposure to steroids and reduces adverse effects. Sin discusses the study findings in an Editorial.