Nicholls and coauthors report the results from the randomized clinical Aliskiren Quantitative Atherosclerosis Regression Intravascular Ultrasound Study (AQUARIUS). In an accompanying Editorial, Tardiff and Grégoire discuss renin-angiotensin system inhibition and secondary cardiovascular prevention.
In a randomized controlled superiority trial involving 13 229 patients with non–ST-segment elevation acute coronary syndromes undergoing early planned invasive strategies, Steg and coauthors compared otamixaban, an intravenous direct factor Xa inhibitor, with unfractionated heparin plus eptifibatide to achieve optimal anticoagulation.
Saitz and coauthors conducted a randomized trial among 563 people with alcohol and other drug dependence to investigate whether chronic care management improves substance use outcomes compared with usual primary care. O’Connor comments in an editorial.
To identify mobility risk factors, screening tools, medical management, need for physical therapy, and efficacy of exercise interventions for older primary care patients with limited mobility, Brown and Flood analyzed evidence reported in 11 peer-reviewed articles assessing mobility limitation and interventions in community-dwelling older adults.