To determine whether sensor-augmented insulin pump with automated low-glucose suspension helps patients with type 1 diabetes avoid hypoglycemic events, Ly and coauthors conducted a randomized trial in which 46 patients with impaired hypoglycemia awareness used the sensor-augmented insulin pump and 49 used a standard insulin pump.
To assess the accuracy, reliability, and potential refinement of clinical decision rules in a new cohort of patients with headache, Perry and coauthors conducted a multicenter cohort study among 2131 adults with headache peaking at 1 hour and no neurologic deficits. Newman-Toker and Edlow provide comment in the related Editorial.
Berry and coauthors determine whether changes in bone mineral density (BMD) after 4 years provide additional information on fracture risk beyond baseline BMD in 802 participants from Massachusetts.
To determine the effects of weight loss on patients with knee osteoarthritis, Messier and coauthors conducted a 18-month randomized clinical trial comparing 3 interventions—intensive diet-induced weight loss plus exercise, intensive diet-induced weight loss, and exercise—among 454 overweight and obese older community-dwelling adults.
Graeme M. Clark and colleagues describe the evolving science of cochlear implants and the histopathology associated with a patient who had his implant removed when it failed in 1983 and again in 1998. Dr Clark has been awarded the 2013 Lasker-DeBakey Clinical Medical Research Award for his pioneering work in cochlear implant development.
Lipsitz discusses the case of a 91-year-old woman with difficult-to-control hypertension and the presentation, pathophysiology, and optimal treatment of hypertension among elderly persons.