Annane and coauthors report the results of the CRISTAL pragmatic randomized trial on the effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients. In an accompanying Editorial, Seymour and Angus discuss making a pragmatic choice for fluid resuscitation.
In this randomized trial of 867 adults, Kravitz and coauthors determine whether a depression engagement video or a tailored interactive multimedia computer program improves initial depression care compared with an attention control group without increasing unnecessary antidepressant prescribing.
To determine whether testosterone therapy is associated with all-cause mortality, myocardial infarction, or stroke, Ho and coauthors conducted a retrospective study involving 8709 men with testosterone levels lower than 300 ng/dL who underwent coronary angiography in the Veterans Affairs system. In an Editorial, Cappola discusses testosterone use and cardiovascular risk.
In a population-based, matched, retrospective cohort study of 10 390 patients who underwent daytime elective laparoscopic cholecystectomy in Ontario, Canada, Vinden and colleagues study outcomes among patients whose procedures were performed by surgeons who had operated the night before vs surgeons who had not. Zinner and Freischlag comment in a related Editorial.
Omuro and DeAngelis review the clinical management of malignant gliomas, including genetic and environmental risk factors such as cell phones, diagnostic pitfalls, symptom management, specific antitumor therapy, and common complications.
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