Marianna K. Baum, PhD; Adriana Campa, PhD; Shenghan Lai, MD, MPH; et al.
JAMA. 2013;310(20):2154-2163. doi:10.1001/jama.2013.280923
Baum and coauthors investigated the effectiveness and safety of micronutrient supplementation in delaying disease progression when implemented in the early stages of HIV disease in patients who are antiretroviral therapy naive. The study was conducted with daily supplements of multivitamins and selenium among 878 adults infected with HIV subtype C in Botswana.
Audio Author Interview:
Effect of Micronutrient Supplementation on Disease Progression in Asymptomatic, Antiretroviral-Naive, HIV-Infected Adults in Botswana
Marzia Lazzerini, PhD; Stefano Martelossi, MD; Giuseppe Magazzù, MD; et al.
JAMA. 2013;310(20):2164-2173. doi:10.1001/jama.2013.280777
In a randomized clinical trial of 56 Italian children with active Crohn disease, Lazzerini and coauthors evaluated the clinical response to thalidomide vs placebo, including measures of clinical remission and adverse events.
Caring for the Critically Ill Patient
Bruno Mourvillier, MD; Florence Tubach, MD, PhD; Diederik van de Beek, MD, PhD; et al.
JAMA. 2013;310(20):2174-2183. doi:10.1001/jama.2013.280506
To test whether induced hypothermia improves outcome in severe bacterial meningitis, Mourvillier
and coauthors assessed 130 patients in 49 intensive care units in France and 98 comatose adults
(defined as having a Glasgow Coma Scale score of ≤8 for <12 hours) with community-acquired
bacterial meningitis who received either cold saline or usual care.
Björn Pasternak, MD, PhD; Henrik Svanström, MSc; Mads Melbye, MD, DrMedSci; et al.
JAMA. 2013;310(20):2184-2190. doi:10.1001/jama.2013.280500
Pasternak and coauthors investigate if oral fluoroquinolone use is associated with increased risk of retinal detachment among more than 6 million participants in Denmark. In an Editorial, Brett discusses how to glean important information from conflicting findings in observational research and apply them to practice.