Sheffield and coauthors investigate the association between intraoperative cholangiography (IOC) use during cholecystectomy and common duct injury in 92 932 Texas Medicare patients aged 66 years or older. In an Editorial, Bilimoria and coauthors discuss the identification and use of the instrumental variable in addressing unmeasured confounders in the estimation of treatment effects.
To identify genetic determinants of coronary heart disease (CHD) that are specific to diabetic patients, Qi and coauthors studied 5 independent sets of CHD cases and non-CHD controls to identify genetic variants related to metabolism.
McWilliams and coauthors examined whether a commercial accountable care organization (ACO) initiative associated with reduced spending and improved quality for private insurance plan enrollees was also associated with changes in spending and quality for Medicare beneficiaries, who were not covered by the initiative.
To assess the addition of sofosbuvir to ribavirin to treat liver disease in patients with hepatitis C virus, especially among patients with unfavorable treatment characteristics—black race, genotype 1a, advanced liver fibrosis, and obesity—Osinusi and coauthors conducted a 2-part, single-center, randomized open-label trial involving 60 patients. They compared the combination treatment of weight-based or low-dose ribavirin treatment plus 400 mg/d of sofosbuvir for 24 weeks.
To identify the most accurate clinical examination findings for rotator cuff disease (RCD),
Hermans and coauthors performed a meta-analysis of 28 relevant studies, extracting data for
likelihood ratios of symptoms and signs of RCD or rotator cuff tear, compared with an acceptable
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