January 1, 2014, Vol 311, No. 1, Pages 5-104

In a double-blind, placebo-controlled, parallel-group, randomized clinical trial with 613 patients, Dysken and coauthors investigated the use of vitamin E (alpha tocopherol), memantine, and a combination to slow progression of mild to moderate Alzheimer disease (AD). In an Editorial, Evans and coauthors discuss the best features in trials of AD therapy and a balance between treatment and prevention.

Kim and coauthors report on the effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest. In an accompanying Editorial, Granger and Becker discuss the use of prehospital and immediate cardiac therapies.

Rubertsson and coauthors conducted a randomized trial among 2589 patients with out-of-hospital cardiac arrest (OHCA) to investigate whether use of a mechanical chest compression device improves 4-hour survival compared with manual cardiopulmonary resuscitation.

Heldman and coauthors tested the safety and efficacy of transendocardial stem cell injections with autologous mesenchymal stem cells and bone marrow mononuclear cells among patients with ischemic cardiomyopathy.