Ebinger and coauthors investigated whether starting thrombolysis in a specialized ambulance reduces delays. They assessed time reduction in 1804 patients for whom a Stroke Emergency Mobile was deployed vs 2969 patients in control weeks. In an Editorial, Grotta discusses efforts to improve treatment outcomes for patients with acute ischemic stroke by reducing time from symptom onset to treatment.
Fonarow and coauthors report on door-to-needle times for tissue plasminogen activator (tPA) administration and clinical outcomes in acute ischemic stroke before and after initiation of a quality improvement initiative. In an accompanying Editorial, Grotta discusses progress in achieving faster treatment with tPA for stroke.
Chamberlain and colleagues tested the hypothesis that lorazepam has better efficacy and safety than diazepam for treating pediatric status epilepticus.
Al-Shahi Salman and coauthors conducted a population-based cohort study of 204 Scottish residents aged 16 years or older to compare the long-term outcomes of conservative management vs interventional treatment for unruptured brain arteriovenous malformations.
Connelly and Lang provide an evidence-based review of the initial pharmacological management of the classical motor symptoms of Parkinson disease and describe the management of medication-related motor complications as well as selected nonmotor symptoms of Parkinson disease.