Pahor and coauthors test the hypothesis that a long-term, structured physical activity program is more effective than a health education program in reducing the risk of major mobility disability among 1635 US men and women aged 70 to 89 years who had physical limitations.
Carvajal and coauthors conducted a randomized clinical trial to assess the efficacy of selumetinib, a selective, non–adenosine triphosphate competitive inhibitor of the mitogen-activated protein kinase kinase (MEK) enzymes MEK1 and MEK2, among 120 patients with metastatic uveal melanoma.
Chatterjee and coauthors performed a meta-analysis to determine benefits and risks associated with thrombolytic therapy vs anticoagulation in acute pulmonary embolism, including the subset of hemodynamically stable patients with right ventricular dysfunction. In an Editorial, Beckman discusses how to assess the net clinical benefit of thrombolysis for patients with pulmonary embolism.
To prevent complications when thoracentesis is performed to find the cause of pleural effusion, Wilcox and colleagues assessed randomized and observational studies of adults undergoing the procedure that examined diagnostic tests for differentiating exudates from transudates.
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