Robertson and coauthors and the Epo Severe TBI Trial Investigators report the results of a randomized clinical trial on the effect of erythropoietin administration and transfusion threshold on neurological recovery after traumatic brain injury.
In a trial involving 30 adult patients with sickle cell phenotype with or without thalassemia, Hsieh and coauthors report that after undergoing nonmyeloablative allogeneic hematopoietic stem cell transplantation from human leukocyte antigen–matched siblings, 26 patients achieved long-term engraftment.
With the first Everolimus for Liver Cancer Evaluation (EVOLVE-1) study, Zhu and coauthors investigated the efficacy of everolimus in patients with advanced hepatocellular carcinoma for whom sorafenib treatment failed. This randomized, double-blind, phase 3 study was conducted among 546 adults with Barcelona Clinic Liver Cancer stage B or C hepatocellular carcinoma and Child-Pugh A liver function.
To determine the molecular basis of multiple respiratory chain complex deficiencies, Taylor and coauthors used a whole-exome sequencing approach in 53 patients with biochemical evidence of multiple respiratory chain complex defects but no primary pathogenic mitochondrial DNA mutation.
In this The Rational Clinical Examination article, Herr and colleagues discuss results of a literature search to evaluate self-report screening instruments to identify generalized anxiety disorder and panic disorder.