The SOLID-TIMI 52 randomized clinical trial evaluated darapladib, a selective lipoprotein-associated phospholipase A2 inhibitor, in patients after ACS and found it did not reduce the risk of coronary events.
Imazio and coauthors conducted a randomized clinical trial among 360 patients undergoing cardiac surgery to determine the efficacy and safety of perioperative use of oral colchicine in reducing postpericardiotomy syndrome, postoperative atrial fibrillation, and postoperative pericardial effusions.
This review of reanalyses of randomized clinical trials determines that a third of the reanalyses led to different conclusions from those of the original studies about which patients should be treated.
Yawn and coauthors summarize a 2014 evidence-based report on the management of sickle cell disease. In an accompanying Editorial, DeBaun discusses the challenge of creating an evidence-based guideline for sickle cell disease.
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