This randomized trial reports point-of-use mixing and administration of 2 doses of H7N9 vaccine at the lowest tested antigen dose with MF59 adjuvant, producing seroconversion in participants.
This randomized trial reports that receipt of a single dose of influenza A(H5N1) vaccine was associated with sufficient immunologic priming to facilitate response to a different H5N1 antigen using a low dose of booster vaccine; in participants not previously vaccinated, low-dose vaccine plus adjuvant was more immunogenic compared with higher doses of unadjuvanted vaccine.
This randomized crossover trial reports that selective oropharyngeal decontamination, vs selective decontamination of the digestive tract, was associated with lower prevalence of antibiotic-resistant gram-negative bacteria.
A cross-sectional study of 1-day prevalence surveys conducted in 183 US acute care hospitals in 10 states found that antimicrobial drugs were used was 49.9% of the time and use of broad-spectrum drugs was common.
Epstein and coauthors identify a source for, and interrupt transmission of, New Delhi metallo-β-lactamase (NDM)–producing carbapenem-resistant Enterobacteriaceae (CRE) in northeastern Illinois.
This Viewpoint discusses the importance of innovation and persistence in tuburculosis control programs.
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