This phase 2 randomized clinical trial comparing treatment with sargramostim plus ipilimumab, compared to ipilimumab alone in patients with unresectable stage III or IV malanoma, reports longer overall survival and lower toxicity, but no difference in progression-free survival.
This retrospective cohort study of US veterans undergoing elective coronary angiography reports that nonobstructive coronary artery disease (CAD), compared with no apparent CAD, was associated with a significantly greater 1-year risk of myocardial infarction and all-cause mortality.
This Mendelian randomization study reports that genetic predisposition to elevated low-density lipoprotein cholesterol was associated with presence of aortic valve calcium and incidence of aortic stenosis.
This open-label, single-group feasibility study among patients with relapsing C difficile infection provides data on adverse events and rates of diarrhea resolution following fecal microbiota transplantation using frozen encapsulated inoculum from unrelated donors.
This Viewpoint discusses approaches to preventing deaths attributable to prescription opioid overdose.
This Viewpoint examines health insurance coverage and access to health care for Latino adults under the Affordable Care Act.
This Viewpoint discusses areas in which the practice of surgery has changed during the past several decades.
This Viewpoint discusses the need to update Medicare policy to improve coverage for hearing and vision rehabilitative services for older adults.
This systematic review of 12 articles involving overweight or obese patients found that intensive behavioral counseling induced weight loss. Although little evidence suggests that such counseling is provided by primary care practitioners, trained interventionists could treat patients in the primary care setting.
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