Shankaran and coauthors determine if longer duration cooling (120 hours), deeper cooling (32.0°C), or both is superior to cooling to 33.5°C for 72 hours in neonates who are full-term with moderate or severe hypoxic ischemic encephalopathy (HIE).
This randomized clinical trial reports that among high-risk children with chronic illness, an enhanced medical home that provided comprehensive care to promote prompt effective care reduced serious illnesses and costs compared with the provision of usual care.
This randomized trial reports that antenatal multiple micronutrient compared with iron–folic acid supplementation did not reduce infant mortality to age 6 months but resulted in a non–statistically significant reduction in stillbirths and significant reductions in preterm births and low birth weight.
In this time series analysis of hospital admissions among older adults during extreme heat events matched to non–heat wave periods, periods of extreme heat were associated with increased risk of hospitalization but the absolute risk increase was small and of uncertain clinical importance.
This Viewpoint discusses the benefit to both patients and physicians of implementing patient-centered approaches to care.
This Viewpoint discusses options for developing more effective pay-for-performance programs.
This Viewpoint discusses the implications of evaluating novel agents in early, rather than advanced, disease states.
This Editorial encourages continuing efforts to improve the efficacy of treatment for perinatal asphyxial encephalopathy.
This systematic review reports that available evidence supports cautious expansion of metformin use in patients with mild to moderate chronic kidney disease.
This Clinical Evidence Synopsis discusses whether antibiotics are associated with improved outcomes in patients with acute bronchitis.
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