In this randomized clinical trial, the investigators tested 2 approaches to prevent or resolve acute respiratory failure and found that high-flow nasal oxygen therapy was not inferior to bilevel positive airway pressure in patients with hypoxemia after cardiothoracic surgery.
In this randomized clinical trial among patients with uncomplicated appendicitis proven by a computed tomographic scan, antibiotic treatment did not meet the prespecified criteria for noninferiority compared with appendectomy.
This simulation study uses Kaiser Permanente patient data to estimate benefits, complications, and costs of colorectal cancer screening stratified by adenoma detection rate and age at initiation.
This retrospective analysis of infants at National Institute of Child Health and Human Development Neonatal Research Network sites did not find differences in mortality or neonatal morbidity between trial participants and nonparticipants.
This Special Communication reports the amount of financial assistance high-income countries and private organizations provide to developing countries for health, and their areas of focus.
This Viewpoint discusses the translation of new knowledge into better health via the integration of science, medicine, and society.
This Viewpoint discusses the Innovation Center of the Centers for Medicare & Medicaid Services (CMS), which was created to evaluate new health care payment and delivery models.
This Viewpoint advocates worldwide policy changes that encourages walking and bicycling and promotes healthful eating by such measures as taxing junk food and subsidizing nutritious food to curb the diabetes epidemic.
This Viewpoint discusses an approach to expanding the pool of potential donors of solid organs for transplantation.
This Guide to Statistics and Methods describes the reasons for conducting a noninferiority trial and how to analyze and interpret the results from a trial that did.
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