This randomized clinical trial reports that among patients with severe community-acquired pneumonia and high initial inflammatory response, the acute use of methylprednisolone compared with placebo decreased treatment failure.
Ebbert and coauthors determine efficacy and safety of varenicline among 1510 cigarette smokers for increasing smoking abstinence rates through smoking reduction.
This international randomized clinical trial found that among adults with Gaucher disease type 1, treatment with eliglustat for 9 months resulted in significant improvements in spleen volume, hemoglobin level, liver volume, and platelet count compared with placebo.
This cohort study showed that in routine care, fondaparinux was associated with lower rates of death and major bleeding among Swedish patients with non–ST-segment myocardial infarction.
This Viewpoint discusses the need for scientific transparency when biomedical innovation takes place outside of the peer-reviewed literature.
This Viewpoint traces the origins of the Affordable Care Act’s employer mandate provision, delineates its all-important rationale, and discusses the likelihood and consequences of its potential repeal.
This Viewpoint discusses the need for regulation meant to ensure the quality, safety, and validity of laboratory-developed diagnostic tests.
This Viewpoint discusses potential drawbacks of regulation meant to to ensure the quality, safety, and validity of laboratory-developed diagnostic tests.
This JAMA Clinical Guidelines Synopsis article evaluates the most recent Advisory Committee for Immunization Practices guideline on use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine among adults aged 65 years or older.
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