February 24, 2015, Vol 313, No. 8, Pages 771-868

In This Issue of JAMA

Highlights

Abstract Full Text

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JAMA. 2015;313(8):771-773. doi:10.1001/jama.2014.11595

Audio Editors' Summary: Risks of combination NSAIDs-antithrombotics in patients with MI, vincristine-related peripheral neuropathy in children with ALL, management of patients with anticoagulation-induced intracerebral hemorrhage, kidney disease staging, and more.

Original Investigation

Association of NSAID Use With Risk of Bleeding and Cardiovascular Events in Patients Receiving Antithrombotic Therapy After Myocardial Infarction

Anne-Marie Schjerning Olsen, MD, PhD; Gunnar H. Gislason, MD, PhD; Patricia McGettigan, MD; et al.

Abstract Full Text

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JAMA. 2015;313(8):805-814. doi:10.1001/jama.2015.0809

This analysis of data from Danish administrative registries reports that among patients receiving antithrombotic therapy after myocardial infarction, use of nonsteroidal anti-inflammatory drugs was associated with increased risk of bleeding and thrombotic events.

Editorial
Potential Hazards of Adding Nonsteroidal Anti-inflammatory Drugs to Antithrombotic Therapy After Myocardial Infarction: Time for More Than a Gut Check
Charles L. Campbell, MD; David J. Moliterno, MD

JAMA

Association of an Inherited Genetic Variant With Vincristine-Related Peripheral Neuropathy in Children With Acute Lymphoblastic Leukemia

Barthelemy Diouf, PharmD, PhD; Kristine R. Crews, PharmD; Glen Lew, MD; et al.

Abstract Full Text

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JAMA. 2015;313(8):815-823. doi:10.1001/jama.2015.0894

This genome-wide association study performed among children with acute lymphoblastic leukemia (ALL) found that an inherited polymorphism in the promoter region of CEP72 was associated with increased risk and severity of vincristine-related peripheral neuropathy.

Audio Author Interview: Genetic Variant and Vincristine Peripheral Neuropathy in ALL

Editorial
Precision Medicine to Improve the Risk and Benefit of Cancer Care: Genetic Factors in Vincristine-Related Neuropathy
Howard L. McLeod, PharmD

JAMA

Anticoagulant Reversal, Blood Pressure Levels, and Anticoagulant Resumption in Patients With Anticoagulation-Related Intracerebral Hemorrhage

Joji B. Kuramatsu, MD; Stefan T. Gerner, MD; Peter D. Schellinger, MD; et al.

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JAMA. 2015;313(8):824-836. doi:10.1001/jama.2015.0846

This retrospective cohort study in Germany reports on analyses of the treatment of oral anticoagulation–associated intracerebral hemorrhage and its association with rates of hematoma enlargement, ischemic and hemorrhagic events with or without resumption of oral anticoagulation, and long-term functional outcome.

Research Letter

Trends in the Proportion of Patients With Lung Cancer Meeting Screening Criteria

Yi Wang, MD; David E. Midthun, MD; Jason A. Wampfler, BS; et al.

Abstract Full Text

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JAMA. 2015;313(8):853-855. doi:10.1001/jama.2015.413

Viewpoint

Scientific Discovery and the Future of Medicine

Genomic Engineering and the Future of Medicine

Jennifer A. Doudna, PhD

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JAMA. 2015;313(8):791-792. doi:10.1001/jama.2015.287

Author Reading: Genomic Engineering and the Future of Medicine

Sharing Clinical Trial Data: Maximizing Benefits, Minimizing Risk

Bernard Lo, MD

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JAMA. 2015;313(8):793-794. doi:10.1001/jama.2015.292

This Viewpoint discusses the benefits, challenges, and risks of sharing clinical trial findings and data.

Optimizing High-Risk Care Management

Brian W. Powers, AB; Sreekanth K. Chaguturu, MD; Timothy G. Ferris, MD, MPH

Abstract Full Text

JAMA. 2015;313(8):795-796. doi:10.1001/jama.2014.18171

This Viewpoint discusses the potential of high-risk care management programs that are practice-based, payer-catalyzed, and purchaser-supported to deliver better care at lower cost.

Medicare and Care Coordination: Expanding the Clinician’s Toolbox

Louise Aronson, MD, MFA; Christopher A. Bautista, MD; Kenneth Covinsky, MD, MPH

Abstract Full Text

JAMA. 2015;313(8):797-798. doi:10.1001/jama.2014.18174

This Viewpoint aims at helping health care professionals understand the components involved with providing non–face-to-face chronic care management (CCM) to Medicare patients.

A Piece of My Mind

For What It’s Worth

Catherine A. Humikowski, MD

Abstract Full Text

JAMA. 2015;313(8):799-800. doi:10.1001/jama.2014.15004

Editorial

Potential Hazards of Adding Nonsteroidal Anti-inflammatory Drugs to Antithrombotic Therapy After Myocardial Infarction: Time for More Than a Gut Check

Charles L. Campbell, MD; David J. Moliterno, MD

Abstract Full Text

JAMA. 2015;313(8):801-802. doi:10.1001/jama.2015.0567

This Viewpoint discusses potental hazards related to the concomitant use of nonsteroidal anti-inflammatory drugs and antithrombotic therapy after myocardial infarction.

Precision Medicine to Improve the Risk and Benefit of Cancer Care: Genetic Factors in Vincristine-Related Neuropathy

Howard L. McLeod, PharmD

Abstract Full Text

JAMA. 2015;313(8):803-804. doi:10.1001/jama.2015.1086

Review

Glomerular Filtration Rate and Albuminuria for Detection and Staging of Acute and Chronic Kidney Disease in Adults: A Systematic Review

Andrew S. Levey, MD; Cassandra Becker, BS; Lesley A. Inker, MD, MS

Abstract Full Text

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JAMA. 2015;313(8):837-846. doi:10.1001/jama.2015.0602

This systematic review summarizes evidence supporting the use of laboratory tests for glomerular filtration rate and albuminuria to detect and stage kidney disease in adults.

Audio: Acute Kidney Injury Caused by Proton Pump Inhibitors

From the JAMA Network

Hydroxychloroquine and the Retina

Michael F. Marmor, MD; Ronald B. Melles, MD

Abstract Full Text

JAMA. 2015;313(8):847-848. doi:10.1001/jama.2014.14558

JAMA Diagnostic Test Interpretation

Elevated Lactate Levels in a Non–Critically Ill Patient

Meng Chen, MD; Tiffany Y. Kim, MD; Antonio M. Pessegueiro, MD

Abstract Full Text

JAMA. 2015;313(8):849-850. doi:10.1001/jama.2014.14074

Medical News & Perspectives

Efforts Seek to Develop Systematic Ways to Objectively Assess Surgeons’ Skills

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2015;313(8):782-784. doi:10.1001/jama.2015.233

The JAMA Forum

On Fear, Distrust, and Ebola

Joshua M. Sharfstein, MD

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JAMA. 2015;313(8):784. doi:10.1001/jama.2015.346

News From the Centers for Disease Control and Prevention

Toxic Puffer Fish Species Illegally Imported to United States

Abstract Full Text

JAMA. 2015;313(8):787. doi:10.1001/jama.2015.384

Cholesterol-Lowering Drugs Taken by 28% of US Population

Abstract Full Text

JAMA. 2015;313(8):787. doi:10.1001/jama.2015.387

Clinical Trials Update

Glaucoma Drug Significantly Slows the Progression of Vision Loss

Anita Slomski, MA

Abstract Full Text

JAMA. 2015;313(8):786. doi:10.1001/jama.2015.0721

Trials Will Assess Effect of Flexible Hours for Trainees

Anita Slomski, MA

Abstract Full Text

JAMA. 2015;313(8):786. doi:10.1001/jama.2015.0723

Progesterone Offers No Benefits in Traumatic Brain Injury

Anita Slomski, MA

Abstract Full Text

JAMA. 2015;313(8):786. doi:10.1001/jama.2015.236

Health Agencies Update

Proposed Rule Seeks to Safeguard Against Phased-Out Chemicals

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2015;313(8):785. doi:10.1001/jama.2015.0746

Officials Strive to Help Consumers Shop for Health Insurance Benefits

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2015;313(8):785. doi:10.1001/jama.2015.0748

Electric Stimulation Device Approved to Treat Obesity

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2015;313(8):785. doi:10.1001/jama.2015.234

The Art of JAMA

By the River: Edward W. Redfield

Jeanette M. Smith, MD

Abstract Full Text

JAMA. 2015;313(8):778-779. doi:10.1001/jama.2014.11597

Poetry and Medicine

compline

Richard Donze, DO, MPH

Abstract Full Text

JAMA. 2015;313(8):860. doi:10.1001/jama.2014.14627

JAMA Revisited

The Effects of Weather on Pain, Comfort and Efficiency

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JAMA. 2015;313(8):861. doi:10.1001/jama.2014.11604

JAMA Patient Page

Advance Directives

Amy E. Thompson, MD

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JAMA. 2015;313(8):868. doi:10.1001/jama.2015.133

Comment & Response

Assessing the Benefit of Vascular Closure Devices After Femoral Artery Puncture

Eric K. Hoffer, MD

Abstract Full Text

JAMA. 2015;313(8):855. doi:10.1001/jama.2015.421

Assessing the Benefit of Vascular Closure Devices After Femoral Artery Puncture—Reply

Stefanie Schulz-Schüpke, MD; Adnan Kastrati, MD; for the Instrumental Sealing of Arterial Puncture Site–CLOSURE Device vs Manual Compression (ISAR-CLOSURE) Trial Investigators

Abstract Full Text

JAMA. 2015;313(8):855-856. doi:10.1001/jama.2015.427