This randomized trial compares risks of viral rebound and viral failure with continuation of ritonavir-boosted lopinavir vs switching to efavirenz among children with human immunodeficiency virus (HIV) infection exposed to nevirapine for prevention of mother-to-child transmission who had initial viral suppression with ritonavir-boosted lopinavir–based therapy.
This pharmacoepidemiology study uses NHANES data to describe trends in prescription drug use among US adults between 1999 and 2012.
This cohort study uses Danish patient registry data to investigate associations between hospital-diagnosed pertussis infections and risk of epilepsy.
This article investigates mechanisms for cancer resistance in elephants and compares cellular response to DNA damage among elephants, healthy human controls, and cancer-prone patients with Li-Fraumeni syndrome.
This study describes gonococcal cephalosporin susceptibility trends using 2006-2014 data from the US Centers for Disease Control and Prevention (CDC) Gonococcal Isolate Surveillance Project and changes in gonorrhea treatment following publication in 2012 of a CDC treatment guideline update.
This national survey study characterizes self-reported use of flavored tobacco products among US youths aged 12 to 17 years in 2013 and 2014.
This Viewpoint discusses themes that emerged at the recent Institute for Translational Medicine and Therapeutics international meeting on conflict of interest.
This Viewpoint discusses the role of the FDA’s Risk Evaluation and Mitigation Strategies program in monitoring drug safety and proposes ways the program can be redesigned for better integration into the US health care system.
This Viewpoint expresses concern over recent court-established First Amendment rights applications to the US FDA’s drug approval process.
This Viewpoint discusses the launch of the Undiagnosed Diseases Network and its features.
This commentary discusses a cluster randomized trial published in JAMA Ophthalmology that compared the effects of personalized education and risk assessment vs usual care during retinal ophthalmologic visits on hemoglobin A1c levels among patients with diabetes.
This Clinical Evidence Synopsis summarizes a Cochrane review on interventions for hirsutism.
This JAMA Clinical Guidelines Synopsis summarizes the American Urological Association’s 2012 guideline for evaluating patients with asymptomatic microhematuria.
This Medical News and Perspectives article discusses the barriers that transgender patients encounter in seeking health care and the resources and education available to physicians.