This Viewpoint anticipates widespread premature use of proprotein convertase subtilisin-kexin type 9 (PCSK-9) inhibitors in response to the challenges some patients experience taking statins and urges caution until trials and experience demonstrate the new drugs are safe.
This Viewpoint proposes widespread screening for atrial fibrillation using accessible and inexpensive means as a public health intervention for preventing stroke.
This Viewpoint discusses low public awareness about risk factors for and symptoms of venous thromboembolism and proposes quality initiatives that might improve recognition of venous thromboembolism and outcomes for patients.
This Viewpoint discusses evidence that the beneficial effects of physical activity may vary depending on activity levels.
This Viewpoint summarizes controversies about the findings of clinical trials of revascularization for treatment of stable ischemic heart disease and argues for informing patients about the uncertainties.
This randomized trial investigated the effects of financial incentives paid to physicians, patients, and both on low-density lipoprotein cholesterol levels among patients with high cardiovascular risk.
This randomized trial compares the effects of endovascular revascularization and supervised exercise vs supervised exercise alone on walking distance and quality of life among patients with peripheral artery disease and intermittent claudication.
This population-based study assessed the prevalence of myocardial scarring, of which the majority were undetected by electrocardiography or clinical evaluation.
This Rational Clinical Examination examines the accuracy of initial history, physical examination, electrocardiogram, and risk scores combined with the first cardiac-specific troponin for diagnosing acute coronary syndrome in the emergency department.
This Guide to Statistics and Methods discusses the use of multiple imputation in statistical analyses when data are missing for some participants in a clinical trial.
A 53-year-old man with chest pain and treated hypertension undergoes an exercise treadmill test, which demonstrates 1.5-mm ST-segment depression in inferolateral leads during recovery. How do you interpret the test result?
This study uses Medicare and Medicaid data to access the frequency of laboratory monitoring during initiation of therapy with mineralocorticoid receptor antagonists in beneficiaries with heart failure.
This Medical News & Perspectives story takes a look at a federal scholarship program that awards graduating medical students with up to $120 000 in loan repayment in exchange for 3 years of full-time service in an area with a shortage of primary care physicians.