This randomized trial reports that the addition of metformin to insulin does not improve glycemic control in overweight adolescents with type 1 diabetes and increases incidence of gastrointestinal adverse events.
This phase 2 study investigates the optimal dose and tolerability of vericiguat, a soluble guanylate cyclase stimulator, in patients with worsening chronic heart failure with reduced left ventricular ejection fraction.
This ecological study uses World Bank World Development database data to investigate associations between national cesarean delivery rates and maternal and neonatal mortality rates in 194 World Health Organization member countries in 2012.
This population epidemiology study uses national health databases in Scotland to investigate associations between planned cesarean delivery in a first pregnancy and childhood asthma requiring hospital admission between 1993 and 2015.
This meta-analysis of trials comparing treatments for obstructive sleep apnea investigates associations between continuous positive airway pressure vs mandibular advancement devices and change in blood pressure.
This study uses US Medical Expenditure Panel Survey data between 2002 and 2010 to estimate the risk of 8 chronic conditions in adults with cerebral palsy.
This Viewpoint calls for investment in suicide prevention research commensurate with the social burden of suicide in the United States, with an emphasis on how to limit access to firearms among people at risk for self-harm.
This Viewpoint describes how Medicare and Medicaid created gaps in inpatient and outpatient mental health services and discusses how pending health reform legislation might close these gaps.
This Viewpoint discusses the challenges of identifying the proper balance of extrinsic and intrinsic motivators for changing physicians’ behavior as a means of improving health care productivity.
This Viewpoint describes the role of stakeholders in developing research questions, reviewing research applications, and conducting research as part of the Patient-Centered Outcomes Research Institute research enterprise.
This Guide to Statistics and Methods discusses the use of dose-response models in phase 2 studies for identifying promising doses to use in further development of a new drug.
A 64-year-old African American woman presented with crusted scalp plaques, erosive stomatitis, and multiple bullae, erosions, and hyperpigmented patches on her trunk and extremities. Her serum creatinine level was 7.1 mg/dL; a complete blood cell count was unremarkable. What would you do next?
This Medical Letter review summarizes the PCSK9 inhibitor evolocumab prescribed as an adjunct to statins and diet in the treatment of hypercholesterolemia.
This Medical News & Perspectives article examines the challenges facing African American men preparing for careers in medicine, as well as recommended strategies to increase the number of black men entering medical school.