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September 2023 - July 1883




December 1, 2015, Vol 314, No. 21, Pages 2205-2320

In This Issue of JAMA


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JAMA. 2015;314(21):2205-2207. doi:10.1001/jama.2014.12117
Original Investigation

Effect of Metformin Added to Insulin on Glycemic Control Among Overweight/Obese Adolescents With Type 1 Diabetes: A Randomized Clinical Trial

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JAMA. 2015;314(21):2241-2250. doi:10.1001/jama.2015.16174

This randomized trial reports that the addition of metformin to insulin does not improve glycemic control in overweight adolescents with type 1 diabetes and increases incidence of gastrointestinal adverse events.

Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction: The SOCRATES-REDUCED Randomized Trial

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JAMA. 2015;314(21):2251-2262. doi:10.1001/jama.2015.15734

This phase 2 study investigates the optimal dose and tolerability of vericiguat, a soluble guanylate cyclase stimulator, in patients with worsening chronic heart failure with reduced left ventricular ejection fraction.

Relationship Between Cesarean Delivery Rate and Maternal and Neonatal Mortality

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JAMA. 2015;314(21):2263-2270. doi:10.1001/jama.2015.15553

This ecological study uses World Bank World Development database data to investigate associations between national cesarean delivery rates and maternal and neonatal mortality rates in 194 World Health Organization member countries in 2012.

Planned Cesarean Delivery at Term and Adverse Outcomes in Childhood Health

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JAMA. 2015;314(21):2271-2279. doi:10.1001/jama.2015.16176

This population epidemiology study uses national health databases in Scotland to investigate associations between planned cesarean delivery in a first pregnancy and childhood asthma requiring hospital admission between 1993 and 2015.

CPAP vs Mandibular Advancement Devices and Blood Pressure in Patients With Obstructive Sleep Apnea: A Systematic Review and Meta-analysis

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JAMA. 2015;314(21):2280-2293. doi:10.1001/jama.2015.16303

This meta-analysis of trials comparing treatments for obstructive sleep apnea investigates associations between continuous positive airway pressure vs mandibular advancement devices and change in blood pressure.

Research Letter

Chronic Conditions in Adults With Cerebral Palsy

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JAMA. 2015;314(21):2303-2305. doi:10.1001/jama.2015.11025

This study uses US Medical Expenditure Panel Survey data between 2002 and 2010 to estimate the risk of 8 chronic conditions in adults with cerebral palsy.


Getting Serious About Reducing Suicide: More “How” and Less “Why”

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JAMA. 2015;314(21):2229-2230. doi:10.1001/jama.2015.15566

This Viewpoint calls for investment in suicide prevention research commensurate with the social burden of suicide in the United States, with an emphasis on how to limit access to firearms among people at risk for self-harm.

Medicare, Medicaid, and Mental Health Care: Historical Perspectives on Reforms Before the US Congress

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JAMA. 2015;314(21):2231-2232. doi:10.1001/jama.2015.13328

This Viewpoint describes how Medicare and Medicaid created gaps in inpatient and outpatient mental health services and discusses how pending health reform legislation might close these gaps.

Harnessing the Right Combination of Extrinsic and Intrinsic Motivation to Change Physician Behavior

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JAMA. 2015;314(21):2233-2234. doi:10.1001/jama.2015.15015

This Viewpoint discusses the challenges of identifying the proper balance of extrinsic and intrinsic motivators for changing physicians’ behavior as a means of improving health care productivity.

Stakeholder-Driven Comparative Effectiveness Research: An Update From PCORI

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JAMA. 2015;314(21):2235-2236. doi:10.1001/jama.2015.15139

This Viewpoint describes the role of stakeholders in developing research questions, reviewing research applications, and conducting research as part of the Patient-Centered Outcomes Research Institute research enterprise.

A Piece of My Mind

Every Little Anniversary

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JAMA. 2015;314(21):2237. doi:10.1001/jama.2015.12385

Cesarean Delivery Rates: Revisiting a 3-Decades-Old Dogma

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JAMA. 2015;314(21):2238-2240. doi:10.1001/jama.2015.15948
JAMA Guide to Statistics and Methods

Dose-Finding Trials: Optimizing Phase 2 Data in the Drug Development Process

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JAMA. 2015;314(21):2294-2295. doi:10.1001/jama.2015.16702

This Guide to Statistics and Methods discusses the use of dose-response models in phase 2 studies for identifying promising doses to use in further development of a new drug.

JAMA Clinical Challenge

Stomatitis, Cutaneous Bullae, and Renal Failure

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JAMA. 2015;314(21):2296-2297. doi:10.1001/jama.2015.10735

A 64-year-old African American woman presented with crusted scalp plaques, erosive stomatitis, and multiple bullae, erosions, and hyperpigmented patches on her trunk and extremities. Her serum creatinine level was 7.1 mg/dL; a complete blood cell count was unremarkable. What would you do next?

From The Medical Letter on Drugs and Therapeutics

Evolocumab (Repatha)—A Second PCSK9 Inhibitor to Lower LDL-Cholesterol

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JAMA. 2015;314(21):2298-2299. doi:10.1001/jama.2015.14772

This Medical Letter review summarizes the PCSK9 inhibitor evolocumab prescribed as an adjunct to statins and diet in the treatment of hypercholesterolemia.

Medical News & Perspectives

AAMC Report Examines How to Increase the Pipeline of Black Men Entering Medical School

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JAMA. 2015;314(21):2222-2224. doi:10.1001/jama.2015.12005

This Medical News & Perspectives article examines the challenges facing African American men preparing for careers in medicine, as well as recommended strategies to increase the number of black men entering medical school.

News From the Food and Drug Administration

New Approaches for Melanoma

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JAMA. 2015;314(21):2227. doi:10.1001/jama.2015.15988

Anticoagulant Can Be Reversed

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JAMA. 2015;314(21):2227. doi:10.1001/jama.2015.16164

New Pancreatic Cancer Drug

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JAMA. 2015;314(21):2227. doi:10.1001/jama.2015.16166
The JAMA Forum

A Healthy Living Wage

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JAMA. 2015;314(21):2224-2225. doi:10.1001/jama.2015.16105
Lab Reports

Kidney Organoids Grown From Stem Cells

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JAMA. 2015;314(21):2226. doi:10.1001/jama.2015.15805

B Cells Fuel Inflammation in Multiple Sclerosis

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JAMA. 2015;314(21):2226. doi:10.1001/jama.2015.16086

Low Levels of Brain Protein Linked to PTSD

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JAMA. 2015;314(21):2226. doi:10.1001/jama.2015.16091
The Art of JAMA

Boy and the Candle: Gerard Sekoto

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JAMA. 2015;314(21):2218-2219. doi:10.1001/jama.2014.12119
Poetry and Medicine


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JAMA. 2015;314(21):2309. doi:10.1001/jama.2015.8427
JAMA Revisited

The Writer as Critic

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JAMA. 2015;314(21):2310. doi:10.1001/jama.2014.12126
JAMA Patient Page

PCSK9 Inhibitors for Treating High Cholesterol

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JAMA. 2015;314(21):2320. doi:10.1001/jama.2015.13748
Comment & Response

The Art of JAMA Article

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JAMA. 2015;314(21):2305. doi:10.1001/jama.2015.13094

The Art of JAMA Article—Reply

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JAMA. 2015;314(21):2305-2306. doi:10.1001/jama.2015.13103

Approaches to Prevention of Cardiovascular Disease

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JAMA. 2015;314(21):2306. doi:10.1001/jama.2015.13088

Approaches to Prevention of Cardiovascular Disease—Reply

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JAMA. 2015;314(21):2306-2307. doi:10.1001/jama.2015.13100

Regulation of Powdered Alcohol

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JAMA. 2015;314(21):2307. doi:10.1001/jama.2015.13091

Regulation of Powdered Alcohol—Reply

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JAMA. 2015;314(21):2307-2308. doi:10.1001/jama.2015.13097

Incorrect Date of Narrative

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JAMA. 2015;314(21):2308. doi:10.1001/jama.2015.12983

Incorrect Nonproprietary Drug Name and Approved Use

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JAMA. 2015;314(21):2308. doi:10.1001/jama.2015.15929
JAMA Masthead


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JAMA. 2015;314(21):2209-2210. doi:10.1001/jama.2014.12118