This randomized trial determines if longer-storage RBCs are inferior to shorter-storage RBCs for tissue oxygenation as measured by reduction in blood lactate levels and cerebral tissue oxygen saturation among children with severe anemia.
This randomized clinical trial evaluates the effect of autologous hematopoietic stem cell transplantation on sustained disease remission among patients with refractory Crohn disease.
This randomized trial evaluates the safety and effectiveness of adding treatment with tumor-treating fields to maintenance temozolomide in patients with glioblastoma after chemoradiation.
This study characterizes trends in the total number of clinical trials and in the proportion of trials funded by the National Institutes of Health and registered at ClinicalTrials.gov between 2006 and 2014.
This Viewpoint discusses the conceptual framework of the Precision Medicine Initiative that could lead to improved health by more effectively matching medical products to the needs and preferences of patients and care partners.
This Viewpoint discusses the newly released Institute of Medicine report about diagnostic error and the most effective strategies for improving the diagnostic process.
This Viewpoint proposes policy options for payers and the federal government to incentivize pharmaceutical manufacturers to adopt value-based pricing of prescription drugs commensurate with the value they bring to patients.
This Viewpoint discusses the challenges facing consumers in choosing a health insurance plan and proposes approaches that might facilitate or simplify the process.
This review summarizes use of antithyroid drugs, radioactive iodine, or thyroidectomy in treating Graves disease.
A 50-year-old man reported experiencing blurry vision for 5 months. He has a BMI of 30.6 and blood pressure of 160/102 mm Hg. Dilated retinal examination showed arteriolar narrowing, microaneurysms, intraretinal hemorrhaging, and cotton-wool spots. What would you do next?
A 19-year-old woman who has had fewer than 6 menstrual cycles per year since menarche and normal luteinizing hormone-to-follicle-stimulating hormone ratio is tested for polycystic ovary syndrome and referred by her gynecologist to an endocrinologist for further testing. How do you interpret these test results?
This Medical News and Perspectives article explores the biological mechanisms underlying brain resilience that could help inform therapeutic strategies to mitigate cognitive decline.
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