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September 2019 - July 1883




December 15, 2015, Vol 314, No. 23, Pages 2469-2580

In This Issue of JAMA


Abstract Full Text
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JAMA. 2015;314(23):2469-2471. doi:10.1001/jama.2014.12145
Original Investigation

Effect of Transfusion of Red Blood Cells With Longer vs Shorter Storage Duration on Elevated Blood Lactate Levels in Children With Severe Anemia: The TOTAL Randomized Clinical Trial

Abstract Full Text
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JAMA. 2015;314(23):2514-2523. doi:10.1001/jama.2015.13977

This randomized trial determines if longer-storage RBCs are inferior to shorter-storage RBCs for tissue oxygenation as measured by reduction in blood lactate levels and cerebral tissue oxygen saturation among children with severe anemia.

Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2015;314(23):2524-2534. doi:10.1001/jama.2015.16700

This randomized clinical trial evaluates the effect of autologous hematopoietic stem cell transplantation on sustained disease remission among patients with refractory Crohn disease.

Preliminary Communication

Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2015;314(23):2535-2543. doi:10.1001/jama.2015.16669

This randomized trial evaluates the safety and effectiveness of adding treatment with tumor-treating fields to maintenance temozolomide in patients with glioblastoma after chemoradiation.

Research Letter

Trends in National Institutes of Health Funding for Clinical Trials Registered in ClinicalTrials.gov

Abstract Full Text
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JAMA. 2015;314(23):2566-2567. doi:10.1001/jama.2015.12206

This study characterizes trends in the total number of clinical trials and in the proportion of trials funded by the National Institutes of Health and registered at ClinicalTrials.gov between 2006 and 2014.


Engaging Patients Across the Spectrum of Medical Product Development: View From the US Food and Drug Administration

Abstract Full Text
JAMA. 2015;314(23):2499-2500. doi:10.1001/jama.2015.15818

This Viewpoint discusses the conceptual framework of the Precision Medicine Initiative that could lead to improved health by more effectively matching medical products to the needs and preferences of patients and care partners.

Measurement Is Essential for Improving Diagnosis and Reducing Diagnostic Error: A Report From the Institute of Medicine

Abstract Full Text
JAMA. 2015;314(23):2501-2502. doi:10.1001/jama.2015.13453

This Viewpoint discusses the newly released Institute of Medicine report about diagnostic error and the most effective strategies for improving the diagnostic process.

Payer and Policy Maker Steps to Support Value-Based Pricing for Drugs

Abstract Full Text
JAMA. 2015;314(23):2503-2504. doi:10.1001/jama.2015.16843

This Viewpoint proposes policy options for payers and the federal government to incentivize pharmaceutical manufacturers to adopt value-based pricing of prescription drugs commensurate with the value they bring to patients.

Choosing a Health Insurance Plan: Complexity and Consequences

Abstract Full Text
JAMA. 2015;314(23):2505-2506. doi:10.1001/jama.2015.15176

This Viewpoint discusses the challenges facing consumers in choosing a health insurance plan and proposes approaches that might facilitate or simplify the process.

A Piece of My Mind

From Shame to Guilt to Love

Abstract Full Text
JAMA. 2015;314(23):2507-2508. doi:10.1001/jama.2015.11521

Storage Duration and Other Measures of Quality of Red Blood Cells for Transfusion

Abstract Full Text
JAMA. 2015;314(23):2509-2510. doi:10.1001/jama.2015.14714

Alternating Electric Fields for the Treatment of Glioblastoma

Abstract Full Text
has audio
JAMA. 2015;314(23):2511-2513. doi:10.1001/jama.2015.16701

Management of Graves Disease: A Review

Abstract Full Text
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JAMA. 2015;314(23):2544-2554. doi:10.1001/jama.2015.16535

This review summarizes use of antithyroid drugs, radioactive iodine, or thyroidectomy in treating Graves disease.

JAMA Clinical Challenge

What Does This Retina Examination Show?

Abstract Full Text
JAMA. 2015;314(23):2555-2556. doi:10.1001/jama.2015.9162

A 50-year-old man reported experiencing blurry vision for 5 months. He has a BMI of 30.6 and blood pressure of 160/102 mm Hg. Dilated retinal examination showed arteriolar narrowing, microaneurysms, intraretinal hemorrhaging, and cotton-wool spots. What would you do next?

JAMA Diagnostic Test Interpretation

Hormonal Evaluation of Hyperandrogenism in Women

Abstract Full Text
JAMA. 2015;314(23):2557-2558. doi:10.1001/jama.2015.11612

A 19-year-old woman who has had fewer than 6 menstrual cycles per year since menarche and normal luteinizing hormone-to-follicle-stimulating hormone ratio is tested for polycystic ovary syndrome and referred by her gynecologist to an endocrinologist for further testing. How do you interpret these test results?

Medical News & Perspectives

The Brain Fights Back: New Approaches to Mitigating Cognitive Decline

Abstract Full Text
JAMA. 2015;314(23):2492-2494. doi:10.1001/jama.2015.15390

This Medical News and Perspectives article explores the biological mechanisms underlying brain resilience that could help inform therapeutic strategies to mitigate cognitive decline.

News From the Food and Drug Administration

New Form of Tenofovir

Abstract Full Text
JAMA. 2015;314(23):2497. doi:10.1001/jama.2015.16486

Two Melanoma Drugs Better Than 1

Abstract Full Text
JAMA. 2015;314(23):2497. doi:10.1001/jama.2015.16798

No Increased Risk of Death With Clopidogrel

Abstract Full Text
JAMA. 2015;314(23):2497. doi:10.1001/jama.2015.16799

Antibody Approved for Asthma

Abstract Full Text
JAMA. 2015;314(23):2497. doi:10.1001/jama.2015.16802
The JAMA Forum

Can Hospitals Help Create Healthy Neighborhoods?

Abstract Full Text
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JAMA. 2015;314(23):2494-2495. doi:10.1001/jama.2015.16749
Global Health

Processed Meat Consumption Associated With Increased Cancer Risk

Abstract Full Text
JAMA. 2015;314(23):2496. doi:10.1001/jama.2015.16382

Improvements in Malaria Control Yield Complex Consequences

Abstract Full Text
JAMA. 2015;314(23):2496. doi:10.1001/jama.2015.16579

Health Benefits of Continuous Water Supply

Abstract Full Text
JAMA. 2015;314(23):2496. doi:10.1001/jama.2015.16580
The Art of JAMA

Le Discret (The Silence): Joseph Ducreux

Abstract Full Text
JAMA. 2015;314(23):2482-2483. doi:10.1001/jama.2014.12147
Poetry and Medicine

Poem for David

Abstract Full Text
JAMA. 2015;314(23):2571. doi:10.1001/jama.2015.8431
JAMA Revisited

The Madness of Sport

Abstract Full Text
JAMA. 2015;314(23):2572. doi:10.1001/jama.2014.12154
JAMA Patient Page

Safe and Healthy International Travel

Abstract Full Text
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JAMA. 2015;314(23):2580. doi:10.1001/jama.2015.15012
Comment & Response

Pioglitazone Use and Risk of Bladder Cancer

Abstract Full Text
JAMA. 2015;314(23):2567-2568. doi:10.1001/jama.2015.13912

Pioglitazone Use and Risk of Bladder Cancer

Abstract Full Text
JAMA. 2015;314(23):2568. doi:10.1001/jama.2015.13909

Pioglitazone Use and Risk of Bladder Cancer—Reply

Abstract Full Text
JAMA. 2015;314(23):2568-2569. doi:10.1001/jama.2015.13915

Fresh vs Cryopreserved Donor Oocytes

Abstract Full Text
JAMA. 2015;314(23):2569-2570. doi:10.1001/jama.2015.13447

Fresh vs Cryopreserved Donor Oocytes—Reply

Abstract Full Text
JAMA. 2015;314(23):2570. doi:10.1001/jama.2015.13450

Wording Errors in the Text

Abstract Full Text
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JAMA. 2015;314(23):2570. doi:10.1001/jama.2015.15495

Clarification of Reporting Programs

Abstract Full Text
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JAMA. 2015;314(23):2570. doi:10.1001/jama.2015.16285
JAMA Masthead


Abstract Full Text
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JAMA. 2015;314(23):2473-2474. doi:10.1001/jama.2014.12146