This randomized clinical trial assesses whether combination naltrexone-bupropion treatment in overweight and obese patients increases major adverse cardiovascular events (MACE) compared with placebo.
This randomized trial evaluates the use of vitamin D supplementation vs placebo in treating knee pain and preventing tibial cartilage loss among patients with symptomatic knee osteoarthritis.
This multicenter cohort study describes a novel clinical risk score developed among children presenting to the emergency department with concussion and head injury within the previous 48 hours to stratify risk of persistent postconcussion symptoms at 28 days.
This register-based cohort study compares rates of cardiomyopathy among women with and without a history of hypertensive disorders of pregnancy to determine whether these disorders are associated with cardiomyopathy beyond the peripartum period.
This study examines the privacy risks and the relationship between privacy disclosures and practices of health apps.
This Viewpoint highlights the societal risks of politically motivated mandates relating to public health guidelines, in particular the recent mammography screening guidelines.
This Viewpoint discusses ethical issues related to rapid access to investigational agents (compassionate use) and outlines a patient-focused approach to responding to compassionate use requests.
This Viewpoint discusses vaccine costs and policy and explains the importance of balancing these factors to provide optimal care while restricting spending on costly interventions with limited benefit.
This Care of the Aging Patient review reports recommendations for less stringent HbA1c target values for older adults with type 2 diabetes.
This Guide to Statistics and Methods discusses the use of time-to-event analysis to evaluate the risk of an adverse outcome from a medical treatment.
This JAMA Clinical Guidelines Synopsis summarizes the American Heart Association’s 2014 scientific statement on prevention, diagnosis, and treatment of postthrombotic syndrome.
This Medical News & Perspectives story discusses the recent lead poisoning crisis in Flint, Michigan, with Mona Hanna-Attisha, MD.