March 15, 2016, Vol 315, No. 11, Pages 1077-1196

In This Issue of JAMA

Highlights

Abstract Full Text

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JAMA. 2016;315(11):1077-1079. doi:10.1001/jama.2015.14162

Audio Editors' Summary: Inhaled xenon for neuroprotection after cardiac arrest, association between vaccine refusal and vaccine-preventable diseases, and more

Original Investigation

Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight

Jessica Tyrrell, PhD; Rebecca C. Richmond, PhD; Tom M. Palmer, PhD; et al.

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JAMA. 2016;315(11):1129-1140. doi:10.1001/jama.2016.1975

This genetic epidemiology study uses mendelian randomization to investigate associations between maternal body mass index and glucose and lipid levels and offspring birth weight between 1929 and 2013.

Evolution of Reporting P Values in the Biomedical Literature, 1990-2015

David Chavalarias, PhD; Joshua David Wallach, BA; Alvin Ho Ting Li, BHSc; et al.

Abstract Full Text

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JAMA. 2016;315(11):1141-1148. doi:10.1001/jama.2016.1952

This study uses text mining analysis of MEDLINE and PubMed Central abstracts to characterize trends and patterns of P value and other statistical reporting since 1990.

Editorial
The Enduring Evolution of the P Value
Demetrios N. Kyriacou, MD, PhD

Preliminary Communication

Caring for the Critically Ill Patient

Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial

Ruut Laitio, MD, PhD; Marja Hynninen, MD, PhD; Olli Arola, MD; et al.

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JAMA. 2016;315(11):1120-1128. doi:10.1001/jama.2016.1933

This randomized clinical trial compares the effect of hypothermia with vs without xenon on magnetic resonance imaging–assessed white matter damage in comatose patients who had experienced out-of-hospital cardiac arrest in Finland.

Research Letter

Suppression of Substance Abuse Claims in Medicaid Data and Rates of Diagnoses for Non–Substance Abuse Conditions

Kathryn Rough, ScM; Brian T. Bateman, MD, MSc; Elisabetta Patorno, MD, DrPH; et al.

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JAMA. 2016;315(11):1164-1166. doi:10.1001/jama.2015.18417

This study examines the association between implementation of a Centers for Medicare & Medicaid Services policy mandating suppression of substance abuse–related claims in Medicare and Medicaid Research Identifiable Files and rates of diagnoses for non–substance abuse conditions in those data.

Viewpoint

Innovations in Health Care Delivery

Does the Country of Origin Matter in Health Care Innovation Diffusion?

Matthew Harris, DPhil, MBBS, FFPH; Yasser Bhatti, DPhil, MSc, MoT, MSc, BEng; Ara Darzi, OM, KBE, PC, FRS, FMedSci

Abstract Full Text

JAMA. 2016;315(11):1103-1104. doi:10.1001/jama.2016.0483

This Viewpoint discusses the need to examine how perceptions of the country of origin may of health care innovations proposed for US settings may influence diffusion of these innovations.

The Proposal for Smoke-Free Public Housing: Benefits, Challenges, and Opportunities for 2 Million Residents

Alan C. Geller, MPH, RN; Vaughan W. Rees, PhD; Daniel R. Brooks, DSc, MPH

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JAMA. 2016;315(11):1105-1106. doi:10.1001/jama.2016.1380

This Viewpoint discusses the benefits and challenges of implementing the US Department of Housing and Urban Development’s proposed rule to ensure smoke-free environments for residents of federally assisted public housing.

Biomarkers and Surrogate Endpoints: Developing Common Terminology and Definitions

Melissa A. Robb, BSN, MS (RegSci); Pamela M. McInnes, DDS, MSc (Dent); Robert M. Califf, MD

Abstract Full Text

JAMA. 2016;315(11):1107-1108. doi:10.1001/jama.2016.2240

This Viewpoint describes the rationale behind an FDA and NIH effort to develop a glossary of common terms and definitions for biomarkers and surrogate endpoints.

Health Care Delivery Innovations That Integrate Care? Yes!But Integrating What?

Regina E. Herzlinger, DBA; Stephen M. Schleicher, MD, MBA; Samyukta Mullangi, MD, MBA

Abstract Full Text

JAMA. 2016;315(11):1109-1110. doi:10.1001/jama.2016.0505

This Viewpoint discusses the use of bundled payment programs organized around procedures or diseases as a means of addressing the challenges of implementing integrated models of health care delivery.

A Piece of My Mind

Meeting the Organ Donor

Louise Wen, MD

Abstract Full Text

JAMA. 2016;315(11):1111-1112. doi:10.1001/jama.2015.18357

Editorial

The Enduring Evolution of the P Value

Demetrios N. Kyriacou, MD, PhD

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JAMA. 2016;315(11):1113-1115. doi:10.1001/jama.2016.2152

Toward High-Reliability Vaccination Efforts in the United States

Matthew M. Davis, MD, MAPP

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JAMA. 2016;315(11):1115-1117. doi:10.1001/jama.2016.1529

To JAMA Peer Reviewers, Authors, and Readers—Thank You

Howard Bauchner, MD; Phil B. Fontanarosa, MD; Robert M. Golub, MD

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JAMA. 2016;315(11):1118-1119. doi:10.1001/jama.2016.2422

Review

Association Between Vaccine Refusal and Vaccine-Preventable Diseases in the United States: A Review of Measles and Pertussis

Varun K. Phadke, MD; Robert A. Bednarczyk, MS, PhD; Daniel A. Salmon, MPH, PhD; et al.

Abstract Full Text

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JAMA. 2016;315(11):1149-1158. doi:10.1001/jama.2016.1353

This evidence review summarizes published reports of measles and pertussis outbreaks to characterize associations with vaccine delay, vaccine refusal, and waning immunity.

Audio Author Interview: Causes of Outbreaks of Vaccine-Preventable Diseases in the United States

Editorial
Toward High-Reliability Vaccination Efforts in the United States
Matthew M. Davis, MD, MAPP

JAMA Clinical Challenge

Neck Pain, Stiffness, and Periorbital Edema in a Man With Diabetes

Soumya Chatterjee, MD, MS, FRCP

Abstract Full Text

JAMA. 2016;315(11):1159-1160. doi:10.1001/jama.2016.1770

A 61-year-old man with hypertension, type 2 diabetes, and hypothyroidism presented with neck pain and stiffness and woody induration extending from the nape of his neck. Examination of his heart, lungs, abdomen, and lower extremities was normal, as was serum albumin level. What would you do next?

From The Medical Letter on Drugs and Therapeutics

Liraglutide (Saxenda) for Weight Loss

Abstract Full Text

JAMA. 2016;315(11):1161-1162. doi:10.1001/jama.2016.2083

This Medical Letter review summarizes information about liraglutide, a GLP-1 receptor agonist approved for long-term weight weight management in adults with a body mass index (BMI) of 30 or greater, or in those with a BMI of 27 or greater plus weight-related comorbidity such as hypertension, dyslipidemia, or diabetes.

Medical News & Perspectives

Researchers Focus on Solving the Zika Riddles

Julie A. Jacob, MA

Abstract Full Text

JAMA. 2016;315(11):1097-1099. doi:10.1001/jama.2016.1219

This Medical News & Perspectives article explores current and planned research into the once-obscure Zika virus, which has swept into more than 20 countries and is associated with a steep increase in cases of microcephaly.

News From the Food and Drug Administration