This randomized trial compares the effects of mindfulness-based stress reduction vs cognitive behavioral therapy vs usual treatment for improving symptoms and physical function among adult patients with chronic lower back pain.
This randomized clinical trial investigated whether fully covered, self-expandable metallic stents are noninferior to plastic stents for achieving stricture resolution in patients with benign biliary strictures and a bile duct diameter ≥6 mm in whom the covered metallic stent would not overlap the cystic duct.
This cohort study assesses whether antibiotic exposure in the first 6 months of life is associated with weight gain among children followed up to age 7 years.
This randomized clinical trial compares the effect of sulindac and erlotinib vs placebo on duodenal adenoma regression among people with familial adenomatous polyposis.
This study reviews research proposals submitted by investigators to open access clinical trials data platforms and describes the data sharing agreements and publications that resulted from the application.
This Viewpoint discusses the challenges of testing vaccines for pregnant women and the need for quick deployment during outbreaks of infectious disease.
This Viewpoint explains the importance of optimized antibiotic use in controlling the increasing rate of illness, mortality, and morbidity resulting from antibiotic-resistant infections.
This Viewpoint advocates for equitiable opportunity for prevention, diagnosis, and treatment of cancer to achieve equivalent outcomes for all US residents.
This Viewpoint discusses sharing the underlying data of genetic testing to develop more precise disease risk estimates and understand whether physicians should act on them.
This commentary discusses a randomized clinical trial published in JAMA Surgery that investigated remission rates of type 2 diabetes among patients treated with bariatric surgery and a lifestyle intervention vs a lifestyle intervention alone.
This JAMA Clinical Guidelines Synopsis summarizes the US Preventive Services Task Force’s 2014 guidelines on screening for gonorrhea, chlamydia, and hepatitis B.
Diagnostic mammography revealed 2 masses in the left breast of a 35-year-old woman. Image-guided core biopsies revealed a poorly differentiated invasive ductal adenocarcinoma. Estrogen receptor was strongly positive in 95% of tumor cells, progesterone receptor was positive in less than 5% of tumor cells, and ERBB2 (HER2) by immunohistochemistry was scored at 1+. How do you interpret the test results?
This Medical News & Perspectives article discusses a clinical trial studying a new technique for imaging cancerous tissue that uses a protease-activated fluorescent probe and a handheld camera.
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