March 22/29, 2016, Vol 315, No. 12, Pages 1203-1299

In This Issue of JAMA

Highlights

Abstract Full Text

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JAMA. 2016;315(12):1203-1205. doi:10.1001/jama.2015.14175

Audio Editors' Summary: Non-drug treatment for back pain, child antibiotics and weight gain, requests for data sharing, and more

Original Investigation

Effect of Mindfulness-Based Stress Reduction vs Cognitive Behavioral Therapy or Usual Care on Back Pain and Functional Limitations in Adults With Chronic Low Back Pain: A Randomized Clinical Trial

Daniel C. Cherkin, PhD; Karen J. Sherman, PhD; Benjamin H. Balderson, PhD; et al.

Abstract Full Text

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JAMA. 2016;315(12):1240-1249. doi:10.1001/jama.2016.2323

This randomized trial compares the effects of mindfulness-based stress reduction vs cognitive behavioral therapy vs usual treatment for improving symptoms and physical function among adult patients with chronic lower back pain.

Audio Author Interview: Mindfulness-Based Stress Reduction vs Cognitive Behavioral Therapy for Chronic Low Back Pain

Editorial
Is It Time to Make Mind-Body Approaches Available for Chronic Low Back Pain?
Madhav Goyal, MD, MPH; Jennifer A. Haythornthwaite, PhD

Effect of Covered Metallic Stents Compared With Plastic Stents on Benign Biliary Stricture Resolution: A Randomized Clinical Trial

Gregory A. Coté, MD, MS; Adam Slivka, MD, PhD; Paul Tarnasky, MD; et al.

Abstract Full Text

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JAMA. 2016;315(12):1250-1257. doi:10.1001/jama.2016.2619

This randomized clinical trial investigated whether fully covered, self-expandable metallic stents are noninferior to plastic stents for achieving stricture resolution in patients with benign biliary strictures and a bile duct diameter ≥6 mm in whom the covered metallic stent would not overlap the cystic duct.

Antibiotic Exposure During the First 6 Months of Life and Weight Gain During Childhood

Jeffrey S. Gerber, MD, PhD; Matthew Bryan, PhD; Rachael K. Ross, MPH; et al.

Abstract Full Text

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JAMA. 2016;315(12):1258-1265. doi:10.1001/jama.2016.2395

This cohort study assesses whether antibiotic exposure in the first 6 months of life is associated with weight gain among children followed up to age 7 years.

Preliminary Communication

Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous Polyposis: A Randomized Clinical Trial

N. Jewel Samadder, MD, MS; Deborah W. Neklason, PhD; Kenneth M. Boucher, PhD; et al.

Abstract Full Text

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JAMA. 2016;315(12):1266-1275. doi:10.1001/jama.2016.2522

This randomized clinical trial compares the effect of sulindac and erlotinib vs placebo on duodenal adenoma regression among people with familial adenomatous polyposis.

Research Letter

Use of Open Access Platforms for Clinical Trial Data

Ann Marie Navar, MD, PhD; Michael J. Pencina, PhD; Jennifer A. Rymer, MD; et al.

Abstract Full Text

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JAMA. 2016;315(12):1283-1284. doi:10.1001/jama.2016.2374

This study reviews research proposals submitted by investigators to open access clinical trials data platforms and describes the data sharing agreements and publications that resulted from the application.

Editorial
Data Sharing: An Ethical and Scientific Imperative
Howard Bauchner, MD; Robert M. Golub, MD; Phil B. Fontanarosa, MD, MBA

Viewpoint

Pregnancy in the Time of Zika: Addressing Barriers for Developing Vaccines and Other Measures for Pregnant Women

Saad B. Omer, MBBS, MPH, PhD; Richard H. Beigi, MD, MSc

Abstract Full Text

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JAMA. 2016;315(12):1227-1228. doi:10.1001/jama.2016.2237

This Viewpoint discusses the challenges of testing vaccines for pregnant women and the need for quick deployment during outbreaks of infectious disease.

New Societal Approaches to Empowering Antibiotic Stewardship

Brad Spellberg, MD; Arjun Srinivasan, MD; Henry F. Chambers, MD

Abstract Full Text

JAMA. 2016;315(12):1229-1230. doi:10.1001/jama.2016.1346

This Viewpoint explains the importance of optimized antibiotic use in controlling the increasing rate of illness, mortality, and morbidity resulting from antibiotic-resistant infections.

Equity in Cancer Care and Outcomes of Treatment: A Different Type of Cancer Moonshot

Ralph I. Horwitz, MD

Abstract Full Text

JAMA. 2016;315(12):1231-1232. doi:10.1001/jama.2016.2242

This Viewpoint advocates for equitiable opportunity for prevention, diagnosis, and treatment of cancer to achieve equivalent outcomes for all US residents.

Clinical Genomics: From Pathogenicity Claims to Quantitative Risk Estimates

Arjun K. Manrai, PhD; John P. A. Ioannidis, MD, DSc; Isaac S. Kohane, MD, PhD

Abstract Full Text

JAMA. 2016;315(12):1233-1234. doi:10.1001/jama.2016.1519

This Viewpoint discusses sharing the underlying data of genetic testing to develop more precise disease risk estimates and understand whether physicians should act on them.

A Piece of My Mind

The Power of “My”

Robert J. Laskowski, MD, MBA

Abstract Full Text

JAMA. 2016;315(12):1235. doi:10.1001/jama.2015.17153

Editorial

Is It Time to Make Mind-Body Approaches Available for Chronic Low Back Pain?

Madhav Goyal, MD, MPH; Jennifer A. Haythornthwaite, PhD

Abstract Full Text

JAMA. 2016;315(12):1236-1237. doi:10.1001/jama.2016.2437

Data Sharing: An Ethical and Scientific Imperative

Howard Bauchner, MD; Robert M. Golub, MD; Phil B. Fontanarosa, MD, MBA

Abstract Full Text

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JAMA. 2016;315(12):1238-1240. doi:10.1001/jama.2016.2420

Editorial
Data Sharing and the Growth of Medical Knowledge
Annette Flanagin, RN, MA; Gregory Curfman, MD; Kirsten Bibbins-Domingo, PhD, MD, MAS

From the JAMA Network

Bariatric Surgery for Type 2 Diabetes: Getting Closer to the Long-term Goal

David Arterburn, MD, MPH; David McCulloch, MD

Abstract Full Text

JAMA. 2016;315(12):1276-1277. doi:10.1001/jama.2016.1884

This commentary discusses a randomized clinical trial published in JAMA Surgery that investigated remission rates of type 2 diabetes among patients treated with bariatric surgery and a lifestyle intervention vs a lifestyle intervention alone.

JAMA Clinical Guidelines Synopsis

Screening for Gonorrhea, Chlamydia, and Hepatitis B

Audrey Tanksley, MD; Adam S. Cifu, MD

Abstract Full Text

JAMA. 2016;315(12):1278-1279. doi:10.1001/jama.2016.0223

This JAMA Clinical Guidelines Synopsis summarizes the US Preventive Services Task Force’s 2014 guidelines on screening for gonorrhea, chlamydia, and hepatitis B.

JAMA Diagnostic Test Interpretation

ERBB2 (HER2) Testing in Breast Cancer

Talal Hilal, MD; Edward H. Romond, MD

Abstract Full Text

JAMA. 2016;315(12):1280-1281. doi:10.1001/jama.2015.17463

Diagnostic mammography revealed 2 masses in the left breast of a 35-year-old woman. Image-guided core biopsies revealed a poorly differentiated invasive ductal adenocarcinoma. Estrogen receptor was strongly positive in 95% of tumor cells, progesterone receptor was positive in less than 5% of tumor cells, and ERBB2 (HER2) by immunohistochemistry was scored at 1+. How do you interpret the test results?

Medical News & Perspectives

Protease-Activated Fluorescent Probe Shows Promise as a Cancer Imaging Device

Julie A. Jacob, MA

Abstract Full Text

JAMA. 2016;315(12):1217-1218. doi:10.1001/jama.2016.0510

This Medical News & Perspectives article discusses a clinical trial studying a new technique for imaging cancerous tissue that uses a protease-activated fluorescent probe and a handheld camera.

News From the Centers for Disease Control and Prevention