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December 2018 - July 1883




April 19, 2016, Vol 315, No. 15, Pages 1539-1672

In This Issue of JAMA


Abstract Full Text
free access has audio
JAMA. 2016;315(15):1539-1541. doi:10.1001/jama.2015.14214

Managing the Risks of Concurrent Surgeries

Abstract Full Text
JAMA. 2016;315(15):1563-1564. doi:10.1001/jama.2016.2305

This View Point presents the practice of concurrent surgeries, calls for 3 steps to regulate the practice, and advocates more direct communication with patients about the practice.

Updating the Toxic Substances Control Act to Protect Human Health

Abstract Full Text
JAMA. 2016;315(15):1565-1566. doi:10.1001/jama.2016.2037

This Viewpoint attempts to explain flaws in bills from both houses of Congress to update the Toxic Substances Control Act for the first time in 40 years.

Pharmacist-Prescribed Birth Control in Oregon and Other States

Abstract Full Text
JAMA. 2016;315(15):1567-1568. doi:10.1001/jama.2016.2327

This Viewpoint discusses new laws that improve women’s access to contraceptives and the ways that critics say the laws fall short.

A Piece of My Mind

Sins of the Fathers

Abstract Full Text
JAMA. 2016;315(15):1569-1570. doi:10.1001/jama.2016.0024

PCSK9 Inhibitors for Statin Intolerance?

Abstract Full Text
JAMA. 2016;315(15):1571-1572. doi:10.1001/jama.2016.3670

PD-1 Blockade in MelanomaA Promising Start, but a Long Way to Go

Abstract Full Text
JAMA. 2016;315(15):1573-1575. doi:10.1001/jama.2016.4012

This Editorial discusses the use of PD-1 blockade in treating patients with metastatic melanoma in the KEYNOTE-1 trial.

Zero Pain Is Not the Goal

Abstract Full Text
JAMA. 2016;315(15):1575-1577. doi:10.1001/jama.2016.1912

The CDC Guideline on Opioid PrescribingRising to the Challenge

Abstract Full Text
JAMA. 2016;315(15):1577-1579. doi:10.1001/jama.2016.1910
Original Investigation

Efficacy and Tolerability of Evolocumab vs Ezetimibe in Patients With Muscle-Related Statin IntoleranceThe GAUSS-3 Randomized Clinical Trial

Abstract Full Text
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JAMA. 2016;315(15):1580-1590. doi:10.1001/jama.2016.3608

This 2-stage randomized clinical trial compared lipid-lowering efficacy of 2 nonstatin therapies, ezetimibe and evolocumab, among patients with uncontrolled low-density lipoprotein cholesterol levels and intolerance to 2 or more statins.

Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial InfarctionA Randomized Clinical Trial

Abstract Full Text
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JAMA. 2016;315(15):1591-1599. doi:10.1001/jama.2016.3609

This randomized trial evaluates the efficacy and safety of losmapimod vs placebo on cardiovascular outcomes in patients hospitalized with an acute myocardial infarction (MI).

Association of Pembrolizumab With Tumor Response and Survival Among Patients With Advanced Melanoma

Abstract Full Text
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JAMA. 2016;315(15):1600-1609. doi:10.1001/jama.2016.4059

This study pools patient cohorts from randomized and nonrandomized studies to investigate associations between pembrolizumab therapy and tumor response among patients with advanced melanoma with and without prior ipilimumab therapy.

Preliminary Communication

Safety and Immunogenicity of Novel Adenovirus Type 26– and Modified Vaccinia Ankara–Vectored Ebola VaccinesA Randomized Clinical Trial

Abstract Full Text
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JAMA. 2016;315(15):1610-1623. doi:10.1001/jama.2016.4218

This phase 1 randomized clinical trial investigated the safety and tolerability of 2 vaccines against Ebola virus: an adenovirus type 26 vector vaccine encoding Ebola glycoprotein (Ad26.ZEBOV) and a modified vaccinia Ankara vector vaccine encoding glycoproteins from Ebola virus, Sudan virus, Marburg virus, and Tai Forest virus nucleoprotein (MVA-BN-Filo).

Special Communication

CDC Guideline for Prescribing Opioids for Chronic Pain—United States, 2016

Abstract Full Text
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JAMA. 2016;315(15):1624-1645. doi:10.1001/jama.2016.1464

This guideline from the Centers for Disease Control and Prevention makes 12 recommendations to improve communication about opioids for chronic pain, to improve the safety and effectiveness of pain treatment, and to reduce risks associated with long-term opioid therapy.

JAMA Guide to Statistics and Methods

Interpretation of Clinical Trials That Stopped Early

Abstract Full Text
JAMA. 2016;315(15):1646-1647. doi:10.1001/jama.2016.2628

This JAMA Guide to Statistics and Methods discusses how to interpret the results of clinical trials that are stopped early based on formal, prespecified stopping rules.

JAMA Clinical Challenge

Pancytopenia in a Patient With Hypothyroidism

Abstract Full Text
JAMA. 2016;315(15):1648-1649. doi:10.1001/jama.2016.2155

A 25-year-old woman with hypothyroidism presented with recent fatigue and weight loss. A peripheral blood smear and bone marrow biopsy showed megaloblastic changes; laboratory analysis showed pancytopenia and elevated levels of lactate dehydrogenase and vitamin B12. What would you do next?

Research Letter

Opioid Prescribing After Surgical Extraction of Teeth in Medicaid Patients, 2000-2010

Abstract Full Text
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JAMA. 2016;315(15):1653-1654. doi:10.1001/jama.2015.19058

This study examines the frequency of opioid prescriptions filled within 7 days of extraction among Medicaid patients.

Opioids Prescribed After Low-Risk Surgical Procedures in the United States, 2004-2012

Abstract Full Text
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JAMA. 2016;315(15):1654-1657. doi:10.1001/jama.2016.0130

This study assesses trends in the amount of hydrocodone/acetaminophen and oxycodone/acetaminophen prescribed for postoperative pain management.

Medical News & Perspectives

Researchers Turn to Canine Clinical Trials to Advance Cancer Therapies

Abstract Full Text
JAMA. 2016;315(15):1550-1552. doi:10.1001/jama.2016.0082

This Medical News & Perspectives article explores how the study of naturally occurring cancers in pet dogs is helping advance cancer research for humans.

News From the Food and Drug Administration

Avoiding Magnetic Interference

Abstract Full Text
JAMA. 2016;315(15):1555. doi:10.1001/jama.2016.3572

Microsensor Monitors Eye Pressure

Abstract Full Text
JAMA. 2016;315(15):1555. doi:10.1001/jama.2016.3600

A First in Hemophilia B Therapy

Abstract Full Text
JAMA. 2016;315(15):1555. doi:10.1001/jama.2016.3603
The JAMA Forum

Addressing Social Issues Affecting Health to Improve US Health Outcomes

Abstract Full Text
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JAMA. 2016;315(15):1552-1553. doi:10.1001/jama.2016.3863
Global Health

Zika Can Cause Guillain-Barré Syndrome

Abstract Full Text
JAMA. 2016;315(15):1554. doi:10.1001/jama.2016.3397

Vaginal Ring Provides Modest Protection Against HIV

Abstract Full Text
JAMA. 2016;315(15):1554. doi:10.1001/jama.2016.3910

Global Disparities Persist in Provision of Surgical Operations

Abstract Full Text
JAMA. 2016;315(15):1554. doi:10.1001/jama.2016.3912
Comment & Response

Financial Incentives and Cholesterol Levels

Abstract Full Text
JAMA. 2016;315(15):1657-1658. doi:10.1001/jama.2016.0309

Exercise Intensity, Dose, and Cardiovascular Disease

Abstract Full Text
JAMA. 2016;315(15):1658-1659. doi:10.1001/jama.2016.0306

Financial Incentives and Cholesterol Levels—Reply

Abstract Full Text
JAMA. 2016;315(15):1658. doi:10.1001/jama.2016.0315

Exercise Intensity, Dose, and Cardiovascular Disease—Reply

Abstract Full Text
JAMA. 2016;315(15):1659. doi:10.1001/jama.2016.0312

Efficacy of the Priority Review Voucher Program

Abstract Full Text
JAMA. 2016;315(15):1659-1660. doi:10.1001/jama.2016.0377

Efficacy of the Priority Review Voucher Program

Abstract Full Text
JAMA. 2016;315(15):1660-1661. doi:10.1001/jama.2016.0386

Grant Award Omitted

Abstract Full Text
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JAMA. 2016;315(15):1661. doi:10.1001/jama.2016.3680

Incorrect Number of Patients in a Figure

Abstract Full Text
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JAMA. 2016;315(15):1661. doi:10.1001/jama.2016.3928

Incorrect Name in Conflict of Interest Disclosure

Abstract Full Text
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JAMA. 2016;315(15):1661. doi:10.1001/jama.2016.3949
The Art of JAMA

Your Golden Hair, MargareteAnslem Kiefer

Abstract Full Text
JAMA. 2016;315(15):1546-1547. doi:10.1001/jama.2015.14216
Poetry and Medicine

b. 1919

Abstract Full Text
JAMA. 2016;315(15):1663. doi:10.1001/jama.2015.19390
JAMA Revisited

The Harrison Antinarcotic Law

Abstract Full Text
JAMA. 2016;315(15):1664. doi:10.1001/jama.2014.11632
JAMA Patient Page

Opioids for Chronic Pain

Abstract Full Text
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JAMA. 2016;315(15):1672. doi:10.1001/jama.2016.3224
JAMA Masthead


Abstract Full Text
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JAMA. 2016;315(15):1543-1544. doi:10.1001/jama.2015.14215