May 3, 2016, Vol 315, No. 17, Pages 1811-1920

In This Issue of JAMA

Highlights

Abstract Full Text

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JAMA. 2016;315(17):1811-1813. doi:10.1001/jama.2015.14240

Audio Editors' Summary: XRT for pancreatic cancer, web-based depression prevention, management of pancreatic cysts, and more

Original Investigation

Effect of Chemoradiotherapy vs Chemotherapy on Survival in Patients With Locally Advanced Pancreatic Cancer Controlled After 4 Months of Gemcitabine With or Without Erlotinib: The LAP07 Randomized Clinical Trial

Pascal Hammel, MD; Florence Huguet, MD; Jean-Luc van Laethem, MD; et al.

Abstract Full Text

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JAMA. 2016;315(17):1844-1853. doi:10.1001/jama.2016.4324

This randomized trial compares the effects of induction gemcitabine with vs without erlotinib in patients with locally advanced pancreatic cancer and, among those responsive to treatment, compares the effects of chemotherapy with vs without radiation.

Audio Author Interview: Chemoradiotherapy vs Chemotherapy for Pancreatic Cancer

Editorial
Optimizing Treatment for Locally Advanced Pancreas Cancer: Progress but No Precision
Deborah Schrag, MD, MPH

JAMA

Effect of a Web-Based Guided Self-help Intervention for Prevention of Major Depression in Adults With Subthreshold Depression: A Randomized Clinical Trial

Claudia Buntrock, MSc; David Daniel Ebert, PhD; Dirk Lehr, PhD; et al.

Abstract Full Text

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JAMA. 2016;315(17):1854-1863. doi:10.1001/jama.2016.4326

This randomized clinical trial compares the effects of a web-based guided self-help intervention vs enhanced usual care for prevention of major depressive disorder among adults with subthreshold depression.

Prevalence of Inappropriate Antibiotic Prescriptions Among US Ambulatory Care Visits, 2010-2011

Katherine E. Fleming-Dutra, MD; Adam L. Hersh, MD, PhD; Daniel J. Shapiro; et al.

Abstract Full Text

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JAMA. 2016;315(17):1864-1873. doi:10.1001/jama.2016.4151

This pharmacoepidemiology study estimates the rate of outpatient, oral antibiotic prescribing by age and diagnosis in the United States and the estimated portion of antibiotic use that may be inappropriate in adults and children.

Editorial
Addressing the Appropriateness of Outpatient Antibiotic Prescribing in the United States: An Important First Step
Pranita D. Tamma, MD, MHS; Sara E. Cosgrove, MD, MS

JAMA

Association Between Availability of a Price Transparency Tool and Outpatient Spending

Sunita Desai, PhD; Laura A. Hatfield, PhD; Andrew L. Hicks, MS; et al.

Abstract Full Text

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JAMA. 2016;315(17):1874-1881. doi:10.1001/jama.2016.4288

This study investigated whether an employer-sponsored health care price transparency tool was associated with lower employee outpatient spending.

Editorial
Price Transparency: Not a Panacea for High Health Care Costs
Kevin G. Volpp, MD, PhD

JAMA

Research Letter

Infections in Early Life and Development of Type 1 Diabetes

Andreas Beyerlein, PhD; Ewan Donnachie, MSc; Sibille Jergens, MSc; et al.

Abstract Full Text

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JAMA. 2016;315(17):1899-1901. doi:10.1001/jama.2016.2181

This population epidemiology study uses regional claims data from Germany to investigate associations between infections in the first 2 years of life and development of type 1 diabetes.

Viewpoint

Patient Safety at the Crossroads

Tejal K. Gandhi, MD, MPH; Donald M. Berwick, MD, MPP; Kaveh G. Shojania, MD

Abstract Full Text

JAMA. 2016;315(17):1829-1830. doi:10.1001/jama.2016.1759

This Viewpoint discusses the National Patient Safety Foundation’s report Free From Harm: Accelerating Patient Safety Improvement 15 Years After “To Err Is Human” and whether the recommendations achieve total systems safety.

Toward a Safer Health Care System: The Critical Need to Improve Measurement

Ashish Jha, MD, MPH; Peter Pronovost, MD, PhD

Abstract Full Text

JAMA. 2016;315(17):1831-1832. doi:10.1001/jama.2016.3448

This Viewpoint discusses how policy makers might develop and implement standardized, validated metrics to track the progress of patient safety improvements.

Eliminating the Term Primary Care “Provider”: Consequences of Language for the Future of Primary Care

Allan H. Goroll, MD

Abstract Full Text

JAMA. 2016;315(17):1833-1834. doi:10.1001/jama.2016.2329

This Viewpoint discusses issues related to the use of “provider” to describe primary care health professionals with varying levels of training and certification and the effects of these issues on quality of care.

A Piece of My Mind

Tasteless Insights

David Bruce Williams, MB, BS, PhD, FRACP

Abstract Full Text

JAMA. 2016;315(17):1835-1836. doi:10.1001/jama.2015.18355

Editorial

Optimizing Treatment for Locally Advanced Pancreas Cancer: Progress but No Precision

Deborah Schrag, MD, MPH

Abstract Full Text

JAMA. 2016;315(17):1837-1838. doi:10.1001/jama.2016.4284

Addressing the Appropriateness of Outpatient Antibiotic Prescribing in the United States: An Important First Step

Pranita D. Tamma, MD, MHS; Sara E. Cosgrove, MD, MS

Abstract Full Text

JAMA. 2016;315(17):1839-1841. doi:10.1001/jama.2016.4286

Price Transparency: Not a Panacea for High Health Care Costs

Kevin G. Volpp, MD, PhD

Abstract Full Text

JAMA. 2016;315(17):1842-1843. doi:10.1001/jama.2016.4325

Review

Pancreatic Cyst Disease: A Review

Alexander Stark, MD; Timothy R. Donahue, MD; Howard A. Reber, MD; et al.

Abstract Full Text

JAMA. 2016;315(17):1882-1893. doi:10.1001/jama.2016.4690

This narrative review summarizes types of pancreatic cysts and management strategies for each based on a synthesis of the published literature.

From the JAMA Network

Recognizing Sun Safety as an Employee Health Issue

Lori A. Crane, PhD, MPH; Robert P. Dellavalle, MD, PhD, MSPH

Abstract Full Text

JAMA. 2016;315(17):1894-1895. doi:10.1001/jama.2016.1008

This commentary discusses a survey study published in JAMA Dermatology that investigated whether government organizations in Colorado had occupational sun protection policies.

JAMA Clinical Challenge

An Elderly Unresponsive Patient

Rahman Shah, MD; Abdul Rashid, MD; Adam Mizeracki, MD

Abstract Full Text

JAMA. 2016;315(17):1896-1897. doi:10.1001/jama.2016.4462

A 79-year-old man with a history of hypertension and stroke presented to the emergency department unresponsive with an undetectable temperature. Blood pressure was 85/55 mm Hg; pulse oximetry was 100% on ambient air. An ECG revealed sinus bradycardia with Osborn waves and attenuated P waves. What would you do next?

Medical News & Perspectives

Twenty Years After Folic Acid Fortification, FDA Ponders Expansion to Corn Masa Flour

Julie A. Jacob, MA

Abstract Full Text

JAMA. 2016;315(17):1821-1822. doi:10.1001/jama.2016.2611

This Medical News & Perspectives article discusses the role of folic acid fortification of cereal grain products in reducing the risk of infant neural tube defects, as well as a push to allow voluntary fortification of corn masa flour.

News From the Food and Drug Administration

New Salvo Against Opioid Abuse

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2016;315(17):1826. doi:10.1001/jama.2016.4409

Boxed Warning for Most Opioids

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2016;315(17):1826. doi:10.1001/jama.2016.4482

Treating and Preventing Anthrax

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2016;315(17):1826. doi:10.1001/jama.2016.4484

The JAMA Forum

Cultural Influences Reflected in Divergent US vs UK Human Embryo Research Policies

Eli Y. Adashi, MD, MS

Abstract Full Text

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JAMA. 2016;315(17):1822-1823. doi:10.1001/jama.2016.3020

JAMA Infographic

Visualizing Health Policy

Eligibility and Coverage Trends in Employer-Sponsored Insurance

Michelle Long, MPH; Matthew Rae, MPH, MPA; Gary Claxton; et al.

Abstract Full Text

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JAMA. 2016;315(17):1824. doi:10.1001/jama.2016.3992

Lab Reports

Dengue Vaccine Performs Well in Small Clinical Trial

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2016;315(17):1825. doi:10.1001/jama.2016.4339

Nanoparticle Strategy Enhances Delivery of Cancer Drugs

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2016;315(17):1825. doi:10.1001/jama.2016.4946

Diet-Induced Obesity and Diabetes Can Be Epigenetically Inherited

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2016;315(17):1825. doi:10.1001/jama.2016.4948

The Art of JAMA

Market in San Miguel: Lew Davis

Thomas B. Cole, MD, MPH

Abstract Full Text

JAMA. 2016;315(17):1818-1819. doi:10.1001/jama.2015.14242

Poetry and Medicine

Weights and Measures

Gaetan Sgro, MD

Abstract Full Text

JAMA. 2016;315(17):1908. doi:10.1001/jama.2015.19392

JAMA Revisited

Cooperation in Social Insurance Investigation

Abstract Full Text

JAMA. 2016;315(17):1909. doi:10.1001/jama.2015.17084

JAMA Patient Page

Dietary Guidelines for Americans—Eat Less Saturated Fat

Aaron P. Frank, MS, RD; Deborah J. Clegg, PhD

Abstract Full Text

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JAMA. 2016;315(17):1919-1920. doi:10.1001/jama.2016.0972

Comment & Response

Noninvasive Ventilation and Outcomes Among Immunocompromised Patients

Jean-Pierre Frat, MD; Rémi Coudroy, MD; Arnaud W. Thille, MD, PhD

Abstract Full Text

JAMA. 2016;315(17):1901-1902. doi:10.1001/jama.2016.0674

Noninvasive Ventilation and Outcomes Among Immunocompromised Patients

Paolo Navalesi, MD; Cesare Gregoretti, MD; Massimo Antonelli, MD

Abstract Full Text

JAMA. 2016;315(17):1902. doi:10.1001/jama.2016.0677

Noninvasive Ventilation and Outcomes Among Immunocompromised Patients—Reply

Virginie Lemiale, MD; Djamel Mokart, MD; Elie Azoulay, MD, PhD; et al.

Abstract Full Text

JAMA. 2016;315(17):1902-1903. doi:10.1001/jama.2016.0692

The Undiagnosed Diseases Program

Brian C. Drolet, MD; Jonathan P. Brower, MD

Abstract Full Text

JAMA. 2016;315(17):1903-1904. doi:10.1001/jama.2016.0443

The Undiagnosed Diseases Program—Reply

William A. Gahl, MD, PhD; Anastasia L. Wise, PhD; Euan A. Ashley, MRCP, DPhil

Abstract Full Text

JAMA. 2016;315(17):1904. doi:10.1001/jama.2016.0454

Treatment of Patients With Stable Ischemic Heart Disease

Fernando Civeira, MD, PhD; Rocío Mateo-Gallego, PhD

Abstract Full Text

JAMA. 2016;315(17):1904-1905. doi:10.1001/jama.2016.0680

Treatment of Patients With Stable Ischemic Heart Disease

Joseph A. Ladapo, MD, PhD

Abstract Full Text

JAMA. 2016;315(17):1905. doi:10.1001/jama.2016.0683

Treatment of Patients With Stable Ischemic Heart Disease—Reply

Sripal Bangalore, MD, MHA; David J. Maron, MD; Judith S. Hochman, MD

Abstract Full Text

JAMA. 2016;315(17):1905-1906. doi:10.1001/jama.2016.0698

Treatment of Patients With Stable Ischemic Heart Disease—Reply

Tamar S. Polonsky, MD, MSCI; Ron Blankstein, MD

Abstract Full Text

JAMA. 2016;315(17):1906-1907. doi:10.1001/jama.2016.0695

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May 3, 2016, Vol 315, No. 17, Pages 1811-1920

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