June 28, 2016, Vol 315, No. 24, Pages 2643-2746

In This Issue of JAMA

Highlights

Abstract Full Text

free access has audio

JAMA. 2016;315(24):2643-2645. doi:10.1001/jama.2015.14331

Audio Editors' Summary: SPRINT trial in older adults, escitalopram for depression in heart failure, post-critical care rehabilitation, diagnosis and management of diarrhea

Original Investigation

Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years: A Randomized Clinical Trial

Jeff D. Williamson, MD, MHS; Mark A. Supiano, MD; William B. Applegate, MD, MPH; et al.

Abstract Full Text

free access has multimedia has audio

JAMA. 2016;315(24):2673-2682. doi:10.1001/jama.2016.7050

This randomized clinical trial evaluates the effects of intensive (<120 mm Hg) systolic blood pressure targets compared with standard (<140 mm Hg) systolic blood pressure targets in patients aged 75 years or older.

Audio Author Interview: Intensive Blood Pressure Control in Adults Aged 75 Years or Older
Audio: Hypertension Management and Dealing With Polypharmacy in Elderly Patients—A Report From the 2016 European Union Geriatric Medical Society Meeting

Editorial
SPRINT Results in Older Patients: How Low to Go?
Aram V. Chobanian, MD

Effect of Escitalopram on All-Cause Mortality and Hospitalization in Patients With Heart Failure and Depression: The MOOD-HF Randomized Clinical Trial

Christiane E. Angermann, MD; Götz Gelbrich, PhD; Stefan Störk, MD, PhD; et al.

Abstract Full Text

free access

JAMA. 2016;315(24):2683-2693. doi:10.1001/jama.2016.7635

This randomized clinical trial compares the effects of escitalopram with placebo on death and hospitalization among patients with chronic systolic heart failure and depression.

Caring for the Critically Ill Patient

Standardized Rehabilitation and Hospital Length of Stay Among Patients With Acute Respiratory Failure: A Randomized Clinical Trial

Peter E. Morris, MD; Michael J. Berry, PhD; D. Clark Files, MD; et al.

Abstract Full Text

free access

JAMA. 2016;315(24):2694-2702. doi:10.1001/jama.2016.7201

This randomized clinical trial compares the effects of physical rehabilitation vs usual care on length of stay of ICU patients with acute respiratory failure.

Editorial
The Challenging Task of Improving the Recovery of ICU Survivors
Shannon L. Goddard, MD; Neill K. J. Adhikari, MDCM, MSc

Caring for the Critically Ill Patient

Effect of a Primary Care Management Intervention on Mental Health–Related Quality of Life Among Survivors of Sepsis: A Randomized Clinical Trial

Konrad Schmidt, MD; Susanne Worrack, MSc; Michael Von Korff, ScD; et al.

Abstract Full Text

free access

JAMA. 2016;315(24):2703-2711. doi:10.1001/jama.2016.7207

This randomized clinical trial compares the effect of a primary care–based management intervention vs usual care on mental health–related quality of life among patients surviving sepsis in the critical care setting.

Editorial
The Challenging Task of Improving the Recovery of ICU Survivors
Shannon L. Goddard, MD; Neill K. J. Adhikari, MDCM, MSc

Research Letter

Sharing of Data From Industry-Funded Registered Clinical Trials

Isabelle Boutron, MD, PhD; Agnes Dechartres, MD, PhD; Gabriel Baron, PhD; et al.

Abstract Full Text

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JAMA. 2016;315(24):2729-2730. doi:10.1001/jama.2016.6310

This study describes the proportion of trials registered at ClinicalTrials.gov and sponsored by 4 pharmaceutical companies included on the Clinical Study Data Request website, where researchers can request access to anonymized patient-level data.

Viewpoint

Innovations in Health Care Delivery

High-Intensity Focused Ultrasound for Prostate Cancer: Novelty or Innovation?

Jim C. Hu, MD, MPH; Aaron Laviana, MD; Art Sedrakyan, MD, PhD

Abstract Full Text

JAMA. 2016;315(24):2659-2660. doi:10.1001/jama.2016.5002

This Viewpoint describes the rapid spread of use of high-intensity focused ultrasound ablation as a treatment for prostate cancer and calls for establishment of a registry to better assess the efficacy and safety of this approach.

A Yellow Fever Epidemic: A New Global Health Emergency?

Daniel Lucey, MD, MPH; Lawrence O. Gostin, JD

Abstract Full Text

JAMA. 2016;315(24):2661-2662. doi:10.1001/jama.2016.6606

This Viewpoint discusses the yellow fever epidemic in Angola as well as in China, the Democratic Republic of Congo, and Kenya due to cases arising from infected travelers from Angola.

Population Health Case Reports: From Clinic to Community

Alina Baciu, MPH, PhD; Joshua M. Sharfstein, MD

Abstract Full Text

JAMA. 2016;315(24):2663-2664. doi:10.1001/jama.2016.4932

This Viepoint describes collaborations between health care organizations and public health departments or community agencies described in articles submitted to the National Academy of Medicine for their Collaborative on Bridging Public Health, Health Care, and Community.

Medicare’s Vision for Advanced Primary Care: New Directions for Care Delivery and Payment

Laura L. Sessums, JD, MD; Sarah J. McHugh, MPH; Rahul Rajkumar, MD, JD

Abstract Full Text

JAMA. 2016;315(24):2665-2666. doi:10.1001/jama.2016.4472

This Viewpoint discusses alternative payment models that reward value and quality, focusing on the Centers for Medicare & Medicaid Services’ Comprehensive Primary Care Plus model for advanced primary care medical homes.

A Piece of My Mind

The Hunger Games

Rebecca E. MacDonell-Yilmaz, MD, MPH

Abstract Full Text

JAMA. 2016;315(24):2667-2668. doi:10.1001/jama.2016.2060

Editorial

SPRINT Results in Older Patients: How Low to Go?

Aram V. Chobanian, MD

Abstract Full Text

JAMA. 2016;315(24):2669-2670. doi:10.1001/jama.2016.7070

The Challenging Task of Improving the Recovery of ICU Survivors

Shannon L. Goddard, MD; Neill K. J. Adhikari, MDCM, MSc

Abstract Full Text

JAMA. 2016;315(24):2671-2672. doi:10.1001/jama.2016.7211

Review

Persistent Diarrhea: A Clinical Review

Herbert L. DuPont, MD

Abstract Full Text

has audio

JAMA. 2016;315(24):2712-2723. doi:10.1001/jama.2016.7833

This Narrative Review summarizes published evidence about the epidemiology, etiology, diagnosis, and management of persistent diarrhea.

Audio: Managing Persistent Diarrhea

From the JAMA Network

Navigating the Dermatological Drug Cost Curve

Ameet Sarpatwari, JD, PhD; Aaron S. Kesselheim, MD, JD, MPH

Abstract Full Text

JAMA. 2016;315(24):2724-2725. doi:10.1001/jama.2016.3851

This commentary discusses a survey study published in JAMA Dermatology that described the changes in the prices of commonly prescribed dermatologic drugs at national chain pharmacies over a 6-year period.

JAMA Diagnostic Test Interpretation

Urinalysis in the Evaluation of Hematuria

Jen-Jane Liu, MD; J. Stephen Jones, MD; Pravin K. Rao, MD

Abstract Full Text

JAMA. 2016;315(24):2726-2727. doi:10.1001/jama.2016.5050

A 65-year-old man with hypertension had trace blood on a routinely performed dipstick urinalysis.What would you do next?

Medical News & Perspectives

Study Links Periodontal Disease Bacteria to Pancreatic Cancer Risk

Julie A. Jacob, MA

Abstract Full Text

JAMA. 2016;315(24):2653-2654. doi:10.1001/jama.2016.6295

This Medical News story discusses research that identifies a positive association between oral microbiome dysbiosis and pancreatic cancer.

News From the Centers for Disease Control and Prevention

HCV Testing in the Cherokee Nation

Abstract Full Text

JAMA. 2016;315(24):2657. doi:10.1001/jama.2016.7757

Indian Health Service Faces Hurdles as More HCV Cases Emerge

Abstract Full Text

JAMA. 2016;315(24):2657. doi:10.1001/jama.2016.7772

Clinical Trials Update

Single Dose of Cholera Vaccine Provides Short-term Protection

Anita Slomski, MA

Abstract Full Text

JAMA. 2016;315(24):2656. doi:10.1001/jama.2016.7253

Smoking Cessation Drugs Pose Little Neuropsychiatric Risk

Anita Slomski, MA

Abstract Full Text

JAMA. 2016;315(24):2656. doi:10.1001/jama.2016.7814

Brain Training Does Not Improve Academic Outcomes in Kids

Anita Slomski, MA

Abstract Full Text

JAMA. 2016;315(24):2656. doi:10.1001/jama.2016.7816

Health Agencies Update

New Resources for Pediatric Palliative Care

Julie A. Jacob, MA

Abstract Full Text

JAMA. 2016;315(24):2655. doi:10.1001/jama.2016.7255

CMS Updates Health Care Facility Fire Safety Regulations

Julie A. Jacob, MA

Abstract Full Text

JAMA. 2016;315(24):2655. doi:10.1001/jama.2016.7898

HHS Announces Medical Bill Redesign Competition

Julie A. Jacob, MA

Abstract Full Text

JAMA. 2016;315(24):2655. doi:10.1001/jama.2016.7900

HHS Awards Funds for Health Center Renovation and Expansion

Julie A. Jacob, MA

Abstract Full Text

JAMA. 2016;315(24):2655. doi:10.1001/jama.2016.7902

The Art of JAMA

The Bright Side: Winslow Homer

Thomas B. Cole, MD, MPH

Abstract Full Text

JAMA. 2016;315(24):2650-2651. doi:10.1001/jama.2015.14333

Poetry and Medicine

We only have our body

Carol Snyder Halberstadt

Abstract Full Text

JAMA. 2016;315(24):2737. doi:10.1001/jama.2016.2000

JAMA Revisited

The Centennial of the Stethoscope

Abstract Full Text

JAMA. 2016;315(24):2738. doi:10.1001/jama.2015.17091

JAMA Patient Page

Generic Drugs

Aria A. Razmaria, MD, MSc

Abstract Full Text

free access

JAMA. 2016;315(24):2746. doi:10.1001/jama.2016.3990

Comment & Response

Prenatal Vitamin D and Offspring Wheezing

Krishnan Bhaskaran, PhD; Liam Smeeth, PhD; Stephen Evans, MSc

Abstract Full Text

JAMA. 2016;315(24):2730. doi:10.1001/jama.2016.4108

Characteristics of Patients Dying With Cancer in Developed Countries

Christof Schaefer, MD, MBioethics, MA

Abstract Full Text

JAMA. 2016;315(24):2731-2732. doi:10.1001/jama.2016.4036

Prenatal Vitamin D and Offspring Wheezing

Dan Merenstein, MD; Frank D’Amico, PhD

Abstract Full Text

JAMA. 2016;315(24):2731. doi:10.1001/jama.2016.4111

Prenatal Vitamin D and Offspring Wheezing—Reply

Augusto A. Litonjua, MD, MPH; Scott T. Weiss, MD, MS

Abstract Full Text

JAMA. 2016;315(24):2731. doi:10.1001/jama.2016.4121

Characteristics of Patients Dying With Cancer in Developed Countries—Reply

Carl Rudolf Blankart, PhD; Ezekiel J. Emanuel, MD, PhD; Justin E. Bekelman, MD; et al.

Abstract Full Text

JAMA. 2016;315(24):2732. doi:10.1001/jama.2016.4042

Measuring and Improving Quality

David W. Baker, MD, MPH; Mark R. Chassin, MD, MPP, MPH

Abstract Full Text

JAMA. 2016;315(24):2733. doi:10.1001/jama.2016.4613

Measuring and Improving Quality—Reply

Elizabeth A. McGlynn, PhD; Eve A. Kerr, MD, MPH

Abstract Full Text

JAMA. 2016;315(24):2733-2734. doi:10.1001/jama.2016.4616

Office Visits Prior to Screening Colonoscopy

Jeffrey J. Leow, MBBS, MPH; Quoc Dien Trinh, MD; Julia McNabb-Baltar, MD, MPH

Abstract Full Text

JAMA. 2016;315(24):2734. doi:10.1001/jama.2016.4289

Office Visits Prior to Screening Colonoscopy—Reply

Kevin R. Riggs, MD, MPH; Eun Ji Shin, MD, PhD; Jodi B. Segal, MD, MPH

Abstract Full Text

JAMA. 2016;315(24):2734-2735. doi:10.1001/jama.2016.4298

Costs of Contraceptive Coverage Under the Affordable Care Act

Nora V. Becker, PhD

Abstract Full Text

JAMA. 2016;315(24):2735. doi:10.1001/jama.2016.4757

Costs of Contraceptive Coverage Under the Affordable Care Act—Reply

Mary C. Politi, PhD; Adam Sonfield, MPP; Tessa Madden, MD, MPH

Abstract Full Text

JAMA. 2016;315(24):2735-2736. doi:10.1001/jama.2016.4763

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June 28, 2016, Vol 315, No. 24, Pages 2643-2746

Caring for the Critically Ill Patient

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