This randomized clinical trial compares the effects of micafungin vs placebo on 28-day fungal infection–free survival among nonneutropenic critically ill patients with ICU-acquired sepsis, Candida species colonization at multiple sites, and multiple organ failure.
This randomized clinical trial compares the effects of high-flow conditioned oxygen therapy vs noninvasive ventilation (NIV) on postextubation respiratory failure and reintubation among critically ill adult patients.
This Danish cohort study investigates the risks of long-term recurrence and mesh-related complications among patients undergoing incisional hernia repair with open mesh, laparoscopic mesh, and open nonmesh surgical techniques.
This randomized clinical trial compares a conservative oxygen protocol vs standard oxygen delivery on the outcomes of mortality, organ failure, and infection in adult patients admitted to a medical-surgical intensive care unit (ICU).
This study assesses working status and productivity change in the first 3 years following surgery for severe obesity.
This Viewpoint discusses the ethics of using an icon in electronic health records to designate patients who have frequent visits.
This Viewpoint argues that the current model of payment coverage decisions for oncology drugs based on third-party drug compendia is outdated and should be abandoned for a new approach.
This Viewpoint emphasizes the contribution of capital spending to escalating health care costs, and argues for improved understanding of the ways capital spending planning and investment can deliver important gains in health care value and population health.
This Viewpoint discusses the trial of American Beverage Association (ABA) et al v City & County of San Francisco over the ordinance requiring billboards advertising sugar-sweetened beverages to include a warning notice.
This JAMA Clinical Guidelines Synopsis summarizes the American Academy of Neurology’s and American Epilepsy Society’s 2015 guideline on management of an unprovoked first seizure in adults.
A 62-year-old woman presented with a 6-month history of hair thinning, itchy scalp, and cold sensitivity, has a mild elevation of her thyroid-stimulating hormone level (4.88 mIU/L) and elevated levels of low-density lipoprotein (155 mg/dL) and total cholesterol (257 mg/dL). How do you interpret the test results?
This Medical News article discusses barriers to widespread implementation of genotype-guided prescribing.
In this essay, novelist Chris Adrian reviews Oliver Sacks' final 'Gratitude' essays and Jenny Diski's end of life memoir, "In Gratitude."
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