November 1, 2016, Vol 316, No. 17, Pages 1731-1838

In This Issue of JAMA

Highlights

Abstract Full Text

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JAMA. 2016;316(17):1731-1733. doi:10.1001/jama.2015.14562

Audio Editors' Summary: Trial of hydrocortisone for sepsis, psychotropics and prisoner violence, understanding confounding by indication, and more

Original Investigation

Caring for the Critically Ill Patient

Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis: The HYPRESS Randomized Clinical Trial

Didier Keh, MD; Evelyn Trips; Gernot Marx, MD; et al.

Abstract Full Text

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JAMA. 2016;316(17):1775-1785. doi:10.1001/jama.2016.14799

This randomized clinical trial compares the effects of hydrocortisone vs placebo on development of septic shock among intensive care patients with severe sepsis who were not in septic shock.

Editorial
Evaluating Glucocorticoids for Sepsis: Time to Change Course
Sachin Yende, MD, MS; B. Taylor Thompson, MD

Caring for the Critically Ill Patient

Association Between Tracheal Intubation During Pediatric In-Hospital Cardiac Arrest and Survival

Lars W. Andersen, MD, MPH; Tia T. Raymond, MD; Robert A. Berg, MD; et al.

Abstract Full Text

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JAMA. 2016;316(17):1786-1797. doi:10.1001/jama.2016.14486

This cohort study using data from the Get With The Guidelines–Resuscitation quality improvement registry to investigate the association between intubation during in-hospital pediatric cardiac arrest and survival to hospital discharge.

Editorial
Intubation During Pediatric CPR: Early, Late, or Not at All?
Allan R. deCaen, MD; Gonzalo Garcia Guerra, MD, MSc; Ian Maconochie, PhD

Association Between Prescription of Major Psychotropic Medications and Violent Reoffending After Prison Release

Zheng Chang, PhD; Paul Lichtenstein, PhD; Niklas Långström, MD; et al.

Abstract Full Text

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JAMA. 2016;316(17):1798-1807. doi:10.1001/jama.2016.15380

This cohort study evaluates whether prescription of psychotropic medications was associated with rates of violent reoffending in Swedish adults released from prison.

Editorial
Mental Illness, Release From Prison, and Social Context
Jeffrey Swanson, PhD

Preliminary Communication

Safety and Wound Outcomes Following Genetically Corrected Autologous Epidermal Grafts in Patients With Recessive Dystrophic Epidermolysis Bullosa

Zurab Siprashvili, PhD; Ngon T. Nguyen, BS; Emily S. Gorell, MS; et al.

Abstract Full Text

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JAMA. 2016;316(17):1808-1817. doi:10.1001/jama.2016.15588

This phase 1 trial evaluates safety and wound outcomes after transplant of genetically corrected autologous epidermal grafts onto wounds of patients with recessive dystrophic epidermolysis bullosa.

Research Letter

Tdap Vaccination During Pregnancy and Microcephaly and Other Structural Birth Defects in Offspring

Malini DeSilva, MD, MPH; Gabriela Vazquez-Benitez, PhD; James D. Nordin, MD, MPH; et al.

Abstract Full Text

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JAMA. 2016;316(17):1823-1825. doi:10.1001/jama.2016.14432

This cohort study uses Vaccine Safety Datalink data to examine associations between maternal Tdap vaccination and structural birth defects in offspring.

Viewpoint

Innovations in Health Care Delivery

Physician Peer Comparisons as a Nonfinancial Strategy to Improve the Value of Care

Amol S. Navathe, MD, PhD; Ezekiel J. Emanuel, MD, PhD

Abstract Full Text

JAMA. 2016;316(17):1759-1760. doi:10.1001/jama.2016.13739

This Viewpoint proposes 8 factors to consider before adopting a peer-comparison model designed to guide physicians toward improving the value of care.

The New CMS Hospital Quality Star Ratings: The Stars Are Not Aligned

Karl Y. Bilimoria, MD, MS; Cynthia Barnard, MBA, PhD

Abstract Full Text

has audio

JAMA. 2016;316(17):1761-1762. doi:10.1001/jama.2016.13679

This Viewpoint discusses hospital rating systems and ways to improve them to drive quality improvement efforts and provide patients with relevant, accessible composite information.

Audio: Using Medicare Star Ratings to Select Hospitals

Opioids Out, Cannabis In: Negotiating the Unknowns in Patient Care for Chronic Pain

Esther K. Choo, MD, MPH; Sarah W. Feldstein Ewing, PhD; Travis I. Lovejoy, PhD, MPH

Abstract Full Text

JAMA. 2016;316(17):1763-1764. doi:10.1001/jama.2016.13677

This Viewpoint discusses challenge of determining appropriate therapies for chronic pain as federal guidelines emphasize efforts to decrease opioid abuse while some US states initiate legalized medical use of cannabis.

Monitoring Marijuana Use in the United States: Challenges in an Evolving Environment

Alejandro Azofeifa, DDS, MSc, MPH; Margaret E. Mattson, PhD; Althea Grant, PhD

Abstract Full Text

JAMA. 2016;316(17):1765-1766. doi:10.1001/jama.2016.13696

This Viewpoint calls for improved surveillance of the use and of health effects of marijuana in the wake of evolving state policies that increase legal access to the drug.

A Piece of My Mind

Moving From Disability to Possibility

Kurt R. Herzer, PhD, MSc

Abstract Full Text

JAMA. 2016;316(17):1767-1768. doi:10.1001/jama.2016.9956

Editorial

Evaluating Glucocorticoids for Sepsis: Time to Change Course

Sachin Yende, MD, MS; B. Taylor Thompson, MD

Abstract Full Text

JAMA. 2016;316(17):1769-1771. doi:10.1001/jama.2016.13904

Mental Illness, Release From Prison, and Social Context

Jeffrey Swanson, PhD

Abstract Full Text

JAMA. 2016;316(17):1771-1772. doi:10.1001/jama.2016.12434

Intubation During Pediatric CPR: Early, Late, or Not at All?

Allan R. deCaen, MD; Gonzalo Garcia Guerra, MD, MSc; Ian Maconochie, PhD

Abstract Full Text

JAMA. 2016;316(17):1772-1774. doi:10.1001/jama.2016.13905

JAMA Guide to Statistics and Methods

Confounding by Indication in Clinical Research

Demetrios N. Kyriacou, MD, PhD; Roger J. Lewis, MD, PhD

Abstract Full Text

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JAMA. 2016;316(17):1818-1819. doi:10.1001/jama.2016.16435

This JAMA Guide to Statistics and Methods reviews the use of methods to control for confounding by indication in clinical research.

Audio: JAMA Guide to Statistics and Methods

From The Medical Letter on Drugs and Therapeutics

Buprenorphine Implants (Probuphine) for Opioid Dependence

Abstract Full Text

JAMA. 2016;316(17):1820-1821. doi:10.1001/jama.2016.10899

This Medical Letter review summarizes what is known about Probuphine, a newly approved subdermal implant form of buprenorphine that provides continuous low levels of drug to prevent opioid use in patients with dependence to opioids.

Medical News & Perspectives

Nobel Laureates Pick Food Fight With GMO Foes

Jeff Lyon

Abstract Full Text

JAMA. 2016;316(17):1752-1753. doi:10.1001/jama.2016.11571

This medical news feature discusses the recent row between Nobel laureates and Greepeace over genetically modified foods.

News From the Food and Drug Administration

First DMD Drug Gains Approval

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2016;316(17):1756. doi:10.1001/jama.2016.15537

Lifesaving App for Opioid Users

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2016;316(17):1756. doi:10.1001/jama.2016.15572

Relief for Ear Pain

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2016;316(17):1756. doi:10.1001/jama.2016.15574

JAMA Infographic

Visualizing Health Policy

Medicare and End-of-Life Care

Shannon Griffin, MPP; Juliette Cubanski, PhD; Tricia Neuman, ScD; et al.

Abstract Full Text

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JAMA. 2016;316(17):1754. doi:10.1001/jama.2016.15577

Lab Reports

Water Bear Genome Uncovers Novel Stress-Tolerant Proteins

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2016;316(17):1755. doi:10.1001/jama.2016.15523

New Insights on Key Neuronal Receptor

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2016;316(17):1755. doi:10.1001/jama.2016.15860

DNA Vaccine Protects Monkeys Against Zika Virus Infection

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2016;316(17):1755. doi:10.1001/jama.2016.15862

The Arts and Medicine

Poetry’s Company: Where Medicine Leaves Us Alone

Jed Myers, MD

Abstract Full Text

JAMA. 2016;316(17):1744-1745. doi:10.1001/jama.2016.13618

Where medicine leaves off, poetry provides companionship in the presence of loss.

Poetry and Medicine

Superior Canal Dehiscence

John Pidgeon

Abstract Full Text

JAMA. 2016;316(17):1830. doi:10.1001/jama.2016.9413

JAMA Revisited

Current Comment

Abstract Full Text

JAMA. 2016;316(17):1831. doi:10.1001/jama.2015.17108

JAMA Patient Page

Erectile Dysfunction

Bobby B. Najari, MD; James A. Kashanian, MD

Abstract Full Text

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JAMA. 2016;316(17):1838. doi:10.1001/jama.2016.12284

Comment & Response

Association of a Genetic Risk Score With Body Mass Index

Marcus R. Munafò, PhD; Kate Tilling, PhD; George Davey Smith, MD, DSc

Abstract Full Text

JAMA. 2016;316(17):1825-1826. doi:10.1001/jama.2016.14933

Association of a Genetic Risk Score With Body Mass Index—Reply

M. Maria Glymour, ScD; Stefan Walter, PhD; Iván Mejía-Guevara, PhD

Abstract Full Text

JAMA. 2016;316(17):1826-1827. doi:10.1001/jama.2016.14939

Association of a Genetic Risk Score With Body Mass Index

Hexuan Liu, MS; Guang Guo, PhD

Abstract Full Text

JAMA. 2016;316(17):1826. doi:10.1001/jama.2016.14945

Assessing the Patient With Arthralgia, Fevers, and Rash

Alexandros Sarantopoulos, MD, PhD; Ioannis Gkougkourelas, MD, PhD; Panagiota Boura, MD, PhD

Abstract Full Text

JAMA. 2016;316(17):1827. doi:10.1001/jama.2016.14924

Assessing the Patient With Arthralgia, Fevers, and Rash—In Reply

Zaid S. Ardalan, MBChB; Abhinav Vasudevan, MBBS; Adam Testro, MBBS, PhD, FRACP

Abstract Full Text

JAMA. 2016;316(17):1828. doi:10.1001/jama.2016.14942

Mechanisms of Ascites Development

Marlys Hearst Witte, MD

Abstract Full Text

JAMA. 2016;316(17):1828-1829. doi:10.1001/jama.2016.15069

Mechanisms of Ascites Development—Reply

Yuval A. Patel, MD; Andrew J. Muir, MD, MHS

Abstract Full Text

JAMA. 2016;316(17):1829. doi:10.1001/jama.2016.15072

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November 1, 2016, Vol 316, No. 17, Pages 1731-1838

Caring for the Critically Ill Patient

Caring for the Critically Ill Patient

Innovations in Health Care Delivery

Visualizing Health Policy

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