This randomized clinical trial compares the effects of evolocumab vs placebo on change in percent atheroma volume among adult patients with angiographic coronary disease despite treatment with statins.
This population epidemiology study estimates county-level patterns in mortality rates for 21 major causes of death in the United States from 1980 through 2014.
This study assesses the sensitivity and specificity of an algorithm based on deep machine learning for automated detection of diabetic retinopathy and diabetic macular edema in retinal fundus photographs.
This noninferiority trial compares human papillomavirus (HPV) type–specific antibody responses among girls and boys aged 9 to 14 years given 2 doses of HPV vaccine vs adolescent girls and young women aged 16 to 26 years given 3 doses.
This study analyzes rates of incident ventilator-associated pneumonia reported 2005-2013 to the Medicare Patient Safety Monitoring System to determine whether those rates accord with those reported for a similar period to the CDC National Healthcare Safety Network.
This Viewpoint discusses advances in artificial intelligence (AI) that challenge the traditional roles of diagnostic radiologists and pathologists and proposes that the 2 roles be merged into that of an information specialist tasked with managing and interpreting information extracted by AI in clinical contexts.
This Viewpoint summarizes the US Centers for Disease Control and Prevention’s Youth Risk Behavior Survey findings detailing the number of lesbian, gay, and bisexual adolescents and their risk exposures and behaviors in the United States in 2015.
This Viewpoint discusses controversies surrounding the US Food and Drug Administration’s 2016 approval of eteplirsen for treatment of Duchenne muscular dystrophy.
This Viewpoint discusses the roles of data monitoring committees (DMCs) in providing oversight of clinical trials and summarizes recommendations from the Clinical Trials Transformation Initiative for improving this oversight as a means of improving DMC processes and effectiveness.
A 28-year-old man develops abdominal discomfort and frequent bowel movements with a positive PCR test for Clostridium difficile toxin 6 weeks after treatment with metronidazole for C difficile infection. What would you do next?
This Medical Letter review summarizes prescription cannabinoid formulations derived from botanical marijuana available for clinical use and the supporting evidence for various indications.
This Medical News article discusses an NIH review of complementary health approaches to chronic pain.
This Arts and Medicine essay examines the new frontiers of medical illustration, including molecular illustration, virtual reality, and 3-D printing.
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