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September 2019 - July 1883




December 13, 2016, Vol 316, No. 22, Pages 2325-2440

In This Issue of JAMA


Abstract Full Text
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JAMA. 2016;316(22):2325-2327. doi:10.1001/jama.2015.14627
Original Investigation

Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients: The GLAGOV Randomized Clinical Trial

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JAMA. 2016;316(22):2373-2384. doi:10.1001/jama.2016.16951

This randomized clinical trial compares the effects of evolocumab vs placebo on change in percent atheroma volume among adult patients with angiographic coronary disease despite treatment with statins.

US County-Level Trends in Mortality Rates for Major Causes of Death, 1980-2014

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JAMA. 2016;316(22):2385-2401. doi:10.1001/jama.2016.13645

This population epidemiology study estimates county-level patterns in mortality rates for 21 major causes of death in the United States from 1980 through 2014.

Innovations in Health Care Delivery

Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs

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JAMA. 2016;316(22):2402-2410. doi:10.1001/jama.2016.17216

This study assesses the sensitivity and specificity of an algorithm based on deep machine learning for automated detection of diabetic retinopathy and diabetic macular edema in retinal fundus photographs.

Immunogenicity of the 9-Valent HPV Vaccine Using 2-Dose Regimens in Girls and Boys vs a 3-Dose Regimen in Women

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JAMA. 2016;316(22):2411-2421. doi:10.1001/jama.2016.17615

This noninferiority trial compares human papillomavirus (HPV) type–specific antibody responses among girls and boys aged 9 to 14 years given 2 doses of HPV vaccine vs adolescent girls and young women aged 16 to 26 years given 3 doses.

Research Letter

Trend in Ventilator-Associated Pneumonia Rates Between 2005 and 2013

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JAMA. 2016;316(22):2427-2429. doi:10.1001/jama.2016.16226

This study analyzes rates of incident ventilator-associated pneumonia reported 2005-2013 to the Medicare Patient Safety Monitoring System to determine whether those rates accord with those reported for a similar period to the CDC National Healthcare Safety Network.


Innovations in Health Care Delivery

Adapting to Artificial Intelligence: Radiologists and Pathologists as Information Specialists

Abstract Full Text
JAMA. 2016;316(22):2353-2354. doi:10.1001/jama.2016.17438

This Viewpoint discusses advances in artificial intelligence (AI) that challenge the traditional roles of diagnostic radiologists and pathologists and proposes that the 2 roles be merged into that of an information specialist tasked with managing and interpreting information extracted by AI in clinical contexts.

Lesbian, Gay, and Bisexual Adolescents: Population Estimate and Prevalence of Health Behaviors

Abstract Full Text
JAMA. 2016;316(22):2355-2356. doi:10.1001/jama.2016.11683

This Viewpoint summarizes the US Centers for Disease Control and Prevention’s Youth Risk Behavior Survey findings detailing the number of lesbian, gay, and bisexual adolescents and their risk exposures and behaviors in the United States in 2015.

Approving a Problematic Muscular Dystrophy Drug: Implications for FDA Policy

Abstract Full Text
JAMA. 2016;316(22):2357-2358. doi:10.1001/jama.2016.16437

This Viewpoint discusses controversies surrounding the US Food and Drug Administration’s 2016 approval of eteplirsen for treatment of Duchenne muscular dystrophy.

Enhancing the Scientific Integrity and Safety of Clinical Trials: Recommendations for Data Monitoring Committees

Abstract Full Text
JAMA. 2016;316(22):2359-2360. doi:10.1001/jama.2016.16070

This Viewpoint discusses the roles of data monitoring committees (DMCs) in providing oversight of clinical trials and summarizes recommendations from the Clinical Trials Transformation Initiative for improving this oversight as a means of improving DMC processes and effectiveness.

A Piece of My Mind


Abstract Full Text
JAMA. 2016;316(22):2361-2362. doi:10.1001/jama.2016.10942

Understanding County-Level, Cause-Specific Mortality: The Great Value—and Limitations—of Small Area Data

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JAMA. 2016;316(22):2363-2365. doi:10.1001/jama.2016.12818

Artificial Intelligence With Deep Learning Technology Looks Into Diabetic Retinopathy Screening

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JAMA. 2016;316(22):2366-2367. doi:10.1001/jama.2016.17563

Translating Artificial Intelligence Into Clinical Care

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JAMA. 2016;316(22):2368-2369. doi:10.1001/jama.2016.17217

Two vs Three Doses of Human Papillomavirus Vaccine: New Policy for the Second Decade of the Vaccination Program

Abstract Full Text
JAMA. 2016;316(22):2370-2372. doi:10.1001/jama.2016.16393
JAMA Diagnostic Test Interpretation

Repeat Clostridium difficile Testing

Abstract Full Text
has active quiz
JAMA. 2016;316(22):2422-2423. doi:10.1001/jama.2016.17173

A 28-year-old man develops abdominal discomfort and frequent bowel movements with a positive PCR test for Clostridium difficile toxin 6 weeks after treatment with metronidazole for C difficile infection. What would you do next?

From The Medical Letter on Drugs and Therapeutics

Cannabis and Cannabinoids

Abstract Full Text
JAMA. 2016;316(22):2424-2425. doi:10.1001/jama.2016.11772

This Medical Letter review summarizes prescription cannabinoid formulations derived from botanical marijuana available for clinical use and the supporting evidence for various indications.

Medical News & Perspectives

As Opioid Epidemic Rages, Complementary Health Approaches to Pain Gain Traction

Abstract Full Text
JAMA. 2016;316(22):2343-2344. doi:10.1001/jama.2016.15029

This Medical News article discusses an NIH review of complementary health approaches to chronic pain.

The JAMA Forum

Genetically Modified Food Labeling: A “Right to Know”?

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JAMA. 2016;316(22):2345-2346. doi:10.1001/jama.2016.17476
News From the Centers for Disease Control and Prevention

Insurer Curbs Opioid Prescriptions

Abstract Full Text
JAMA. 2016;316(22):2349. doi:10.1001/jama.2016.17522

Health Workers’ Risks for Respiratory Virus

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JAMA. 2016;316(22):2349. doi:10.1001/jama.2016.17557
JAMA Infographic

Visualizing Health Metrics

Firearm Deaths in the United States and Globally, 1990-2015

Abstract Full Text
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JAMA. 2016;316(22):2347. doi:10.1001/jama.2016.16676
Capitol Health Call

Research Across Borders

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JAMA. 2016;316(22):2348. doi:10.1001/jama.2016.17140

Fixing Obamacare Takes Back Seat, Poll Finds

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JAMA. 2016;316(22):2348. doi:10.1001/jama.2016.18025

Congress Delivers Medical Twofer

Abstract Full Text
JAMA. 2016;316(22):2348. doi:10.1001/jama.2016.18027

If at First You Don’t Succeed

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JAMA. 2016;316(22):2348. doi:10.1001/jama.2016.18029
The Arts and Medicine

New Frontiers of Medical Illustration

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JAMA. 2016;316(22):2340-2341. doi:10.1001/jama.2016.17728

This Arts and Medicine essay examines the new frontiers of medical illustration, including molecular illustration, virtual reality, and 3-D printing.

Poetry and Medicine


Abstract Full Text
JAMA. 2016;316(22):2434. doi:10.1001/jama.2016.1588
JAMA Revisited

From Internal Combustion to Electricity

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JAMA. 2016;316(22):2435. doi:10.1001/jama.2015.17113
JAMA Patient Page

Recovery After Stroke

Abstract Full Text
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JAMA. 2016;316(22):2440. doi:10.1001/jama.2016.16901
Comment & Response

Lack of Benefit for Liraglutide in Heart Failure

Abstract Full Text
JAMA. 2016;316(22):2429. doi:10.1001/jama.2016.15387

Lack of Benefit for Liraglutide in Heart Failure—Reply

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JAMA. 2016;316(22):2429-2430. doi:10.1001/jama.2016.15394

Factors Influencing Prescription Drug Costs in the United States

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JAMA. 2016;316(22):2430-2431. doi:10.1001/jama.2016.17290

Factors Influencing Prescription Drug Costs in the United States

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JAMA. 2016;316(22):2431. doi:10.1001/jama.2016.17293

Factors Influencing Prescription Drug Costs in the United States—Reply

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JAMA. 2016;316(22):2431-2432. doi:10.1001/jama.2016.17299

Expectations for Physicians Prescribing Marijuana

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JAMA. 2016;316(22):2432-2433. doi:10.1001/jama.2016.16103

Expectations for Physicians Prescribing Marijuana—Reply

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JAMA. 2016;316(22):2433. doi:10.1001/jama.2016.16109

Label Error in Figure

Abstract Full Text
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JAMA. 2016;316(22):2433. doi:10.1001/jama.2016.18247
JAMA Masthead


Abstract Full Text
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JAMA. 2016;316(22):2329-2330. doi:10.1001/jama.2015.14628