August 2, 2016, Vol 316, No. 5, Pages 471-557

In This Issue of JAMA

Highlights

Abstract Full Text

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JAMA. 2016;316(5):471-473. doi:10.1001/jama.2015.14406

Audio Editors' Summary: Liraglutide for heart failure, vasopressin for septic shock, President Barack Obama on US health care reform, and more

Original Investigation

Effects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial

Kenneth B. Margulies, MD; Adrian F. Hernandez, MD, MHS; Margaret M. Redfield, MD; et al.

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JAMA. 2016;316(5):500-508. doi:10.1001/jama.2016.10260

This randomized clinical trial compares the effects of liraglutide vs placebo on time to death and rehospitalization and on time-averaged proportional change in N-terminal pro-B-type natriuretic peptide level among patients with heart failure and reduced left ventricular ejection fraction (LVEF) of 40% or lower.

Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock: The VANISH Randomized Clinical Trial

Anthony C. Gordon, MD; Alexina J. Mason, PhD; Neeraja Thirunavukkarasu, MSc; et al.

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JAMA. 2016;316(5):509-518. doi:10.1001/jama.2016.10485

This randomized clinical trial compares the effect of vasopressin vs norepinephrine on kidney failure in patients with septic shock.

Innovations in Health Care Delivery

Association Between Off-site Central Monitoring Using Standardized Cardiac Telemetry and Clinical Outcomes Among Non–Critically Ill Patients

Daniel J. Cantillon, MD; Molly Loy, MSN, RN; Alicia Burkle, BSB; et al.

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JAMA. 2016;316(5):519-524. doi:10.1001/jama.2016.10258

This study describes process measures and clinical outcomes associated with use of off-site central monitoring of non–critically ill patients in the Cleveland Clinic health system.

Research Letter

Trends in Seniors’ Use of Digital Health Technology in the United States, 2011-2014

David M. Levine, MD, MA; Stuart R. Lipsitz, ScD; Jeffrey A. Linder, MD, MPH, FACP

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JAMA. 2016;316(5):538-540. doi:10.1001/jama.2016.9124

This national survey study characterizes trends in use of technology and digital health care services among Medicare beneficiaries between 2011 and 2014.

Special Communication

United States Health Care Reform: Progress to Date and Next Steps

Barack Obama, JD

Abstract Full Text

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JAMA. 2016;316(5):525-532. doi:10.1001/jama.2016.9797

In this Special Communication, President Barack Obama reviews the Affordable Care Act: why he pursued it, what it has effected, and how the health care system can still be improved.

Editorial
The Affordable Care Act and the Future of US Health Care
Howard Bauchner, MD
US Health Care Reform: Cost Containment and Improvement in Quality
Peter R. Orszag, PhD
The Future of the Affordable Care Act: Reassessment and Revision
Stuart M. Butler, PhD, MA
The Past and Future of the Affordable Care Act
Jonathan Skinner, PhD; Amitabh Chandra, PhD

Viewpoint

Innovations in Health Care Delivery

Incorporating Health Status in Routine Care to Improve Health Care Value: The VA Patient Reported Health Status Assessment (PROST) System

Steven M. Bradley, MD, MPH; John S. Rumsfeld, MD, PhD; P. Michael Ho, MD, PhD

Abstract Full Text

JAMA. 2016;316(5):487-488. doi:10.1001/jama.2016.6495

This Viewpoint describes the VA Patient Reported Health Status Assessment (PROST) system, designed to capture and prioritize patient-reported health status measures, and discusses early experiences using the system to improve care for veterans undergoing percutaneous coronary intervention.

Improving Safety for Hospitalized Patients: Much Progress but Many Challenges Remain

Richard Kronick, PhD; Sharon Arnold, PhD; Jeffrey Brady, MD, MPH

Abstract Full Text

JAMA. 2016;316(5):489-490. doi:10.1001/jama.2016.7887

This Viewpoint discusses declines in hospital rates of patient harms between 2010 and 2014 and the efforts required to continue systematic nationwide improvement in safety.

A Piece of My Mind

How Many Have You Done?

Anna Reisman, MD

Abstract Full Text

JAMA. 2016;316(5):491. doi:10.1001/jama.2016.1996

Editorial

The Affordable Care Act and the Future of US Health Care

Howard Bauchner, MD

Abstract Full Text

free access

JAMA. 2016;316(5):492-493. doi:10.1001/jama.2016.9872

Editorial
US Health Care Reform: Cost Containment and Improvement in Quality
Peter R. Orszag, PhD
The Future of the Affordable Care Act: Reassessment and Revision
Stuart M. Butler, PhD, MA
The Past and Future of the Affordable Care Act
Jonathan Skinner, PhD; Amitabh Chandra, PhD

US Health Care Reform: Cost Containment and Improvement in Quality

Peter R. Orszag, PhD

Abstract Full Text

free access

JAMA. 2016;316(5):493-495. doi:10.1001/jama.2016.9876

Editorial
The Affordable Care Act and the Future of US Health Care
Howard Bauchner, MD

The Future of the Affordable Care Act: Reassessment and Revision

Stuart M. Butler, PhD, MA

Abstract Full Text

free access

JAMA. 2016;316(5):495-497. doi:10.1001/jama.2016.9881

Editorial
The Affordable Care Act and the Future of US Health Care
Howard Bauchner, MD

The Past and Future of the Affordable Care Act

Jonathan Skinner, PhD; Amitabh Chandra, PhD

Abstract Full Text

free access

JAMA. 2016;316(5):497-499. doi:10.1001/jama.2016.10158

Editorial
The Affordable Care Act and the Future of US Health Care
Howard Bauchner, MD

JAMA Guide to Statistics and Methods

Logistic Regression: Relating Patient Characteristics to Outcomes

Juliana Tolles, MD, MHS; William J. Meurer, MD, MS

Abstract Full Text

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JAMA. 2016;316(5):533-534. doi:10.1001/jama.2016.7653

This JAMA Guide to Statistics and Methods reviews the use of logistic regression methods to quantify associations between patient characteristics and clinical outcomes.

Audio: JAMA Guide to Statistics and Methods
JAMAevidence: Guide to Statistics and Methods: Logistic Regression—What It Is and How to Use It in Clinical Research
JAMAevidence: Users' Guides to the Medical Literature: Correlation and Regression With Dr Jaeschke

JAMA Diagnostic Test Interpretation

Cortisol in the Evaluation of Adrenal Insufficiency

Fady Hannah-Shmouni, MD; Andrew Demidowich, MD; Constantine A. Stratakis, MD, D(Med)Sc

Abstract Full Text

JAMA. 2016;316(5):535-536. doi:10.1001/jama.2016.8360

A 32-year-old woman with hypothyroidism presented for evaluation of chronic fatigue and weight loss of 9 kg. She had normal vital signs, darkening of her palmar creases, and buccal mucosa. Her test results showed low cortisol and elevated adrenocorticotropin hormone levels. What would you do next?

Medical News & Perspectives

National Academies Hit the Brakes on Gene Drive–Modified Organisms

Jennifer Abbasi

Abstract Full Text

JAMA. 2016;316(5):482-483. doi:10.1001/jama.2016.8830

This Medical News article discusses an advisory report on gene drive–modified organisms.

News From the Food and Drug Administration

New Weapon Against Cholera

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2016;316(5):485. doi:10.1001/jama.2016.9769

Obesity Device Drains Stomach

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2016;316(5):485. doi:10.1001/jama.2016.9807

FDA Tackles Cyber Drug Crime

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2016;316(5):485. doi:10.1001/jama.2016.9809

Lab Reports

Vascular Dysfunction an Early Contributor to Alzheimer Disease

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2016;316(5):484. doi:10.1001/jama.2016.10010

Maternal Obesity Affects Sociality of Offspring by Altering Gut Bacteria

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2016;316(5):484. doi:10.1001/jama.2016.10012

New Insights Into Arbovirus Infection and Immunity

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2016;316(5):484. doi:10.1001/jama.2016.9623

The Art of JAMA

Cave Dwellings: Deforrest Judd

Carrie A. Butt

Abstract Full Text

JAMA. 2016;316(5):480-481. doi:10.1001/jama.2015.14408

Poetry and Medicine

SI-SA

Richard Donze, DO, MPH

Abstract Full Text

JAMA. 2016;316(5):547. doi:10.1001/jama.2016.3538

JAMA Revisited

The Protection of Micro-Organisms

Abstract Full Text

JAMA. 2016;316(5):548. doi:10.1001/jama.2015.17096

JAMA Patient Page

Testicular Mass

Richard S. Matulewicz, MD, MS; Joshua J. Meeks, MD, PhD

Abstract Full Text

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JAMA. 2016;316(5):557. doi:10.1001/jama.2016.2445

Comment & Response

Metallic vs Plastic Stents for Benign Biliary Strictures

Guido Costamagna, MD

Abstract Full Text

JAMA. 2016;316(5):540. doi:10.1001/jama.2016.7303

Metallic vs Plastic Stents for Benign Biliary Strictures—Reply

Gregory A. Coté, MD, MS

Abstract Full Text

JAMA. 2016;316(5):540-541. doi:10.1001/jama.2016.7306

Early Antibiotic Exposure and Childhood Weight Gain

Susanna Esposito, MD

Abstract Full Text

JAMA. 2016;316(5):541. doi:10.1001/jama.2016.7300

Laboratory Testing in the Setting of Diabetic Scleredema

David Alter, MD, DABCC

Abstract Full Text

JAMA. 2016;316(5):542. doi:10.1001/jama.2016.6644

Early Antibiotic Exposure and Childhood Weight Gain—Reply

Jeffrey S. Gerber, MD, PhD; Matthew Bryan, PhD; Virginia A. Stallings, MD

Abstract Full Text

JAMA. 2016;316(5):542. doi:10.1001/jama.2016.7309

Laboratory Testing in the Setting of Diabetic Scleredema—Reply

Soumya Chatterjee, MD, MS, FRCP

Abstract Full Text

JAMA. 2016;316(5):543. doi:10.1001/jama.2016.6647

High-Flow vs Conventional Oxygen Therapy and Risk of Reintubation

Gaspard Cadier, MD; Stanislas de Guillebon, MD; Alexandre Boyer, MD, PhD

Abstract Full Text

JAMA. 2016;316(5):543-544. doi:10.1001/jama.2016.7735

Sulindac and Erlotinib for Familial Adenomatous Polyposis

Claude Matuchansky, MD

Abstract Full Text

JAMA. 2016;316(5):544-545. doi:10.1001/jama.2016.7592

High-Flow vs Conventional Oxygen Therapy and Risk of Reintubation—Reply

Gonzalo Hernández, MD, PhD; Rafael Fernández, MD, PhD

Abstract Full Text

JAMA. 2016;316(5):544. doi:10.1001/jama.2016.7738

Sulindac and Erlotinib for Familial Adenomatous Polyposis—Reply

N. Jewel Samadder, MD; Deborah W. Neklason, PhD; Randall W. Burt, MD

Abstract Full Text

JAMA. 2016;316(5):545. doi:10.1001/jama.2016.7595

Correction

Incorrect Wording in News From the Food and Drug Administration

Abstract Full Text

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JAMA. 2016;316(5):545. doi:10.1001/jama.2016.10731

Incomplete URL

Abstract Full Text

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JAMA. 2016;316(5):545. doi:10.1001/jama.2016.9941

Incorrect Test Name

Abstract Full Text

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JAMA. 2016;316(5):545. doi:10.1001/jama.2016.9943

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August 2, 2016, Vol 316, No. 5, Pages 471-557

Innovations in Health Care Delivery

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