January 3, 2017, Vol 317, No. 1, Pages 3-98

In This Issue of JAMA

Highlights

Abstract Full Text

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JAMA. 2017;317(1):3-5. doi:10.1001/jama.2016.12932

Audio Editors' Summary: Biosimilar therapy for breast cancer, zoledronic acid for bone metastases, the future of Obamacare under Donald Trump, and more

Original Investigation

Effect of a Proposed Trastuzumab Biosimilar Compared With Trastuzumab on Overall Response Rate in Patients With ERBB2 (HER2)–Positive Metastatic Breast Cancer: A Randomized Clinical Trial

Hope S. Rugo, MD; Abhijit Barve, MD, PhD, MBA; Cornelius F. Waller, MD; et al.

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JAMA. 2017;317(1):37-47. doi:10.1001/jama.2016.18305

This randomized clinical trial compares the overall response rate and safety of a proposed trastuzumab biosimilar vs trastuzumab and a taxane among women with ERBB2 (HER2)–positive metastatic breast cancer.

Editorial
Scientific Evidence and Financial Obligations to Ensure Access to Biosimilars for Cancer Treatment
Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA; Robert M. Golub, MD
Biosimilar Therapy for ERBB2 (HER2)–Positive Breast Cancer: Close Enough?
Harold J. Burstein, MD, PhD; Deborah Schrag, MD, MPH

Effect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients With Bone Metastases: A Randomized Clinical Trial

Andrew L. Himelstein, MD; Jared C. Foster, PhD; James L. Khatcheressian, MD; et al.

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JAMA. 2017;317(1):48-58. doi:10.1001/jama.2016.19425

This noninferiority trial compares the effects of zoledronic acid administered every 12 weeks vs every 4 weeks over 2 years on prevention of skeletal events in patients with bone metastases due to breast cancer, prostate cancer, or multiple myeloma.

Birth Defects Among Fetuses and Infants of US Women With Evidence of Possible Zika Virus Infection During Pregnancy

Margaret A. Honein, PhD; April L. Dawson, MPH; Emily E. Petersen, MD; et al.

Abstract Full Text

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JAMA. 2017;317(1):59-68. doi:10.1001/jama.2016.19006

This study uses 2016 Centers for Disease Control and Prevention Zika registry data to describe the proportion of fetuses or infants with birth defects following possible maternal Zika virus infection.

Editorial
Preliminary Results From the US Zika Pregnancy Registry: Untangling Risks for Congenital Anomalies
William J. Muller, MD, PhD; Emily S. Miller, MD, MPH

Geographic Variations and Temporal Trends in Cesarean Delivery Rates in China, 2008-2014

Hong-Tian Li, MD, PhD; Shusheng Luo, MD; Leonardo Trasande, MD, MPP; et al.

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JAMA. 2017;317(1):69-76. doi:10.1001/jama.2016.18663

This population epidemiology study describes the trends in the rate of cesarean deliveries and maternal and perinatal deaths in mainland China, 2008-2014.

Research Letter

Funding and Publication of Research on Gun Violence and Other Leading Causes of Death

David E. Stark, MD, MS; Nigam H. Shah, MBBS, PhD

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JAMA. 2017;317(1):84-85. doi:10.1001/jama.2016.16215

This study uses Centers for Disease Control and Prevention mortality and federal agency research funding data to compare funding for and publication of gun violence research with that for 30 other leading causes of death in the United States.

Viewpoint

The Affordable Care Act: Moving Forward in the Coming Years

Lawrence O. Gostin, JD; David A. Hyman, JD, MD; Peter D. Jacobson, JD, MPH

Abstract Full Text

JAMA. 2017;317(1):19-20. doi:10.1001/jama.2016.18908

This Viewpoint examines the likely reforms that the new administration will propose to the Affordable Care Act, including health savings accounts, cross-state insurance plans, Medicaid block grants, and tort reform.

The Future of the ACA and Health Care Policy in the United States

Gail R. Wilensky, PhD

Abstract Full Text

JAMA. 2017;317(1):21-22. doi:10.1001/jama.2016.18762

In this Viewpoint, economist and health policy expert Gail Wilensky examines the possible effects the recent shift in federal executive and legislative control might have on US health policy.

Body Image Disorders and Abuse of Anabolic-Androgenic Steroids Among Men

Harrison G. Pope Jr, MD; Jag H. Khalsa, MS, PhD; Shalender Bhasin, MB, BS

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JAMA. 2017;317(1):23-24. doi:10.1001/jama.2016.17441

This Viewpoint discusses the health risks of the use of anabolic-androgenic steroids by men with muscle dysmorphia, a form of body image disorder characterized by obsessive preoccupation with a muscular appearance.

Social Determinants of Health: Caveats and Nuances

Victor R. Fuchs, PhD

Abstract Full Text

JAMA. 2017;317(1):25-26. doi:10.1001/jama.2016.17335

This Viewpoint discusses the increasing recognition of the importance of social determinants of health as an adjunct to biological and medical care factors and highlights several caveats for applying social determinants to the explanation of variations in health outcomes.

A Piece of My Mind

Little White Lies

Daniel F. Chen, MD

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JAMA. 2017;317(1):27-28. doi:10.1001/jama.2016.11872

Editorial

Health Care in the United States: A Right or a Privilege

Howard Bauchner, MD

Abstract Full Text

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JAMA. 2017;317(1):29. doi:10.1001/jama.2016.19687

Editorial
Health Care Is a Right and Not a Privilege
Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA

Biosimilar Therapy for ERBB2 (HER2)–Positive Breast Cancer: Close Enough?

Harold J. Burstein, MD, PhD; Deborah Schrag, MD, MPH

Abstract Full Text

JAMA. 2017;317(1):30-32. doi:10.1001/jama.2016.18979

Editorial
Scientific Evidence and Financial Obligations to Ensure Access to Biosimilars for Cancer Treatment
Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA; Robert M. Golub, MD

Scientific Evidence and Financial Obligations to Ensure Access to Biosimilars for Cancer Treatment

Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA; Robert M. Golub, MD

Abstract Full Text

JAMA. 2017;317(1):33-34. doi:10.1001/jama.2016.18743

Editorial
Biosimilar Therapy for ERBB2 (HER2)–Positive Breast Cancer: Close Enough?
Harold J. Burstein, MD, PhD; Deborah Schrag, MD, MPH

Preliminary Results From the US Zika Pregnancy Registry: Untangling Risks for Congenital Anomalies

William J. Muller, MD, PhD; Emily S. Miller, MD, MPH

Abstract Full Text

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JAMA. 2017;317(1):35-36. doi:10.1001/jama.2016.18632

From the JAMA Network

Delirium: An Important Postoperative Complication

Michael E. Zenilman, MD

Abstract Full Text

JAMA. 2017;317(1):77-78. doi:10.1001/jama.2016.18174

This commentary discusses a cohort study published in JAMA Surgery that reported associations between major postoperative complications, delirium, and prolonged increases in health resource use.

JAMA Clinical Guidelines Synopsis

Nonsurgical Management of Urinary Incontinence in Women

Sandra Culbertson, MD; Andrew M. Davis, MD, MPH

Abstract Full Text

JAMA. 2017;317(1):79-80. doi:10.1001/jama.2016.18433

This JAMA Clinical Guidelines Synopsis summarizes the American College of Physicians’ 2014 guideline on nonsurgical management of urinary incontinence in women.

JAMA Clinical Challenge

Eyebrow and Eyelash Loss

Jules B. Lipoff, MD; Katherine T. Steele, MD; Neha Jariwala

Abstract Full Text

JAMA. 2017;317(1):81-82. doi:10.1001/jama.2016.17688

A 41-year-old man who had immigrated from Costa Rica 10 years prior presented with paresthesias in his hands and feet, loss of the eyebrows and eyelashes, and skin changes including mild erythema of the earlobes, fingers, and toes. He reported taking no medications. What would you do next?

Medical News & Perspectives

23andMe, Big Data, and the Genetics of Depression

Jennifer Abbasi

Abstract Full Text

JAMA. 2017;317(1):14-16. doi:10.1001/jama.2016.14136

This Medical News article discusses the use of consumer data for disease genomics research.

News From the Food and Drug Administration

New Tool to Study Zika Virus

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2017;317(1):18. doi:10.1001/jama.2016.19026

Reducing Recurrent Strokes

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2017;317(1):18. doi:10.1001/jama.2016.19075

Relief for Painful Intercourse

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2017;317(1):18. doi:10.1001/jama.2016.19077

Lab Reports

Long-Acting Oral Drug Device May Help Combat Malaria

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2017;317(1):17. doi:10.1001/jama.2016.18686

Implantable Device Reverses Leg Paralysis in Monkeys

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2017;317(1):17. doi:10.1001/jama.2016.19835

Pancreatic Cancer Blocked From Invading Nearby Nerves

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2017;317(1):17. doi:10.1001/jama.2016.19837

The Arts and Medicine

Pure Genius, the TV Series: Is There an ICD-10 Code for Hyperbole?

Eric J. Topol, MD

Abstract Full Text

JAMA. 2017;317(1):10-11. doi:10.1001/jama.2016.19011

This Arts and Medicine essay reviews the 2016 ABC TV series Pure Genius, which imagines health care in a futuristic hospital founded by a Silicon Valley entrepreneur to provide high-tech care for complex patients.

Poetry and Medicine