This randomized clinical trial compares the overall response rate and safety of a proposed trastuzumab biosimilar vs trastuzumab and a taxane among women with ERBB2 (HER2)–positive metastatic breast cancer.
This noninferiority trial compares the effects of zoledronic acid administered every 12 weeks vs every 4 weeks over 2 years on prevention of skeletal events in patients with bone metastases due to breast cancer, prostate cancer, or multiple myeloma.
This study uses 2016 Centers for Disease Control and Prevention Zika registry data to describe the proportion of fetuses or infants with birth defects following possible maternal Zika virus infection.
This population epidemiology study describes the trends in the rate of cesarean deliveries and maternal and perinatal deaths in mainland China, 2008-2014.
This study uses Centers for Disease Control and Prevention mortality and federal agency research funding data to compare funding for and publication of gun violence research with that for 30 other leading causes of death in the United States.
This Viewpoint examines the likely reforms that the new administration will propose to the Affordable Care Act, including health savings accounts, cross-state insurance plans, Medicaid block grants, and tort reform.
In this Viewpoint, economist and health policy expert Gail Wilensky examines the possible effects the recent shift in federal executive and legislative control might have on US health policy.
This Viewpoint discusses the health risks of the use of anabolic-androgenic steroids by men with muscle dysmorphia, a form of body image disorder characterized by obsessive preoccupation with a muscular appearance.
This Viewpoint discusses the increasing recognition of the importance of social determinants of health as an adjunct to biological and medical care factors and highlights several caveats for applying social determinants to the explanation of variations in health outcomes.
This commentary discusses a cohort study published in JAMA Surgery that reported associations between major postoperative complications, delirium, and prolonged increases in health resource use.
This JAMA Clinical Guidelines Synopsis summarizes the American College of Physicians’ 2014 guideline on nonsurgical management of urinary incontinence in women.
A 41-year-old man who had immigrated from Costa Rica 10 years prior presented with paresthesias in his hands and feet, loss of the eyebrows and eyelashes, and skin changes including mild erythema of the earlobes, fingers, and toes. He reported taking no medications. What would you do next?
This Medical News article discusses the use of consumer data for disease genomics research.
This Arts and Medicine essay reviews the 2016 ABC TV series Pure Genius, which imagines health care in a futuristic hospital founded by a Silicon Valley entrepreneur to provide high-tech care for complex patients.
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