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December 2017 - July 1883




January 3, 2017, Vol 317, No. 1, Pages 3-98

In This Issue of JAMA


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JAMA. 2017;317(1):3-5. doi:10.1001/jama.2016.12932

The Affordable Care ActMoving Forward in the Coming Years

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JAMA. 2017;317(1):19-20. doi:10.1001/jama.2016.18908

This Viewpoint examines the likely reforms that the new administration will propose to the Affordable Care Act, including health savings accounts, cross-state insurance plans, Medicaid block grants, and tort reform.

The Future of the ACA and Health Care Policy in the United States

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JAMA. 2017;317(1):21-22. doi:10.1001/jama.2016.18762

In this Viewpoint, economist and health policy expert Gail Wilensky examines the possible effects the recent shift in federal executive and legislative control might have on US health policy.

Body Image Disorders and Abuse of Anabolic-Androgenic Steroids Among Men

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JAMA. 2017;317(1):23-24. doi:10.1001/jama.2016.17441

This Viewpoint discusses the health risks of the use of anabolic-androgenic steroids by men with muscle dysmorphia, a form of body image disorder characterized by obsessive preoccupation with a muscular appearance.

Social Determinants of HealthCaveats and Nuances

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JAMA. 2017;317(1):25-26. doi:10.1001/jama.2016.17335

This Viewpoint discusses the increasing recognition of the importance of social determinants of health as an adjunct to biological and medical care factors and highlights several caveats for applying social determinants to the explanation of variations in health outcomes.

A Piece of My Mind

Little White Lies

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JAMA. 2017;317(1):27-28. doi:10.1001/jama.2016.11872

Health Care in the United States: A Right or a Privilege

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JAMA. 2017;317(1):29. doi:10.1001/jama.2016.19687

Biosimilar Therapy for ERBB2 (HER2)–Positive Breast CancerClose Enough?

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JAMA. 2017;317(1):30-32. doi:10.1001/jama.2016.18979

Scientific Evidence and Financial Obligations to Ensure Access to Biosimilars for Cancer Treatment

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JAMA. 2017;317(1):33-34. doi:10.1001/jama.2016.18743

Preliminary Results From the US Zika Pregnancy RegistryUntangling Risks for Congenital Anomalies

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JAMA. 2017;317(1):35-36. doi:10.1001/jama.2016.18632
Original Investigation

Effect of a Proposed Trastuzumab Biosimilar Compared With Trastuzumab on Overall Response Rate in Patients With ERBB2 (HER2)–Positive Metastatic Breast CancerA Randomized Clinical Trial

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JAMA. 2017;317(1):37-47. doi:10.1001/jama.2016.18305

This randomized clinical trial compares the overall response rate and safety of a proposed trastuzumab biosimilar vs trastuzumab and a taxane among women with ERBB2 (HER2)–positive metastatic breast cancer.

Effect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients With Bone MetastasesA Randomized Clinical Trial

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JAMA. 2017;317(1):48-58. doi:10.1001/jama.2016.19425

This noninferiority trial compares the effects of zoledronic acid administered every 12 weeks vs every 4 weeks over 2 years on prevention of skeletal events in patients with bone metastases due to breast cancer, prostate cancer, or multiple myeloma.

Birth Defects Among Fetuses and Infants of US Women With Evidence of Possible Zika Virus Infection During Pregnancy

Abstract Full Text
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JAMA. 2017;317(1):59-68. doi:10.1001/jama.2016.19006

This study uses 2016 Centers for Disease Control and Prevention Zika registry data to describe the proportion of fetuses or infants with birth defects following possible maternal Zika virus infection.

Geographic Variations and Temporal Trends in Cesarean Delivery Rates in China, 2008-2014

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JAMA. 2017;317(1):69-76. doi:10.1001/jama.2016.18663

This population epidemiology study describes the trends in the rate of cesarean deliveries and maternal and perinatal deaths in mainland China, 2008-2014.

From The JAMA Network

DeliriumAn Important Postoperative Complication

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JAMA. 2017;317(1):77-78. doi:10.1001/jama.2016.18174

This commentary discusses a cohort study published in JAMA Surgery that reported associations between major postoperative complications, delirium, and prolonged increases in health resource use.

JAMA Clinical Guidelines Synopsis

Nonsurgical Management of Urinary Incontinence in Women

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JAMA. 2017;317(1):79-80. doi:10.1001/jama.2016.18433

This JAMA Clinical Guidelines Synopsis summarizes the American College of Physicians’ 2014 guideline on nonsurgical management of urinary incontinence in women.

JAMA Clinical Challenge

Eyebrow and Eyelash Loss

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JAMA. 2017;317(1):81-82. doi:10.1001/jama.2016.17688

A 41-year-old man who had immigrated from Costa Rica 10 years prior presented with paresthesias in his hands and feet, loss of the eyebrows and eyelashes, and skin changes including mild erythema of the earlobes, fingers, and toes. He reported taking no medications. What would you do next?

Research Letter

Funding and Publication of Research on Gun Violence and Other Leading Causes of Death

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JAMA. 2017;317(1):84-85. doi:10.1001/jama.2016.16215

This study uses Centers for Disease Control and Prevention mortality and federal agency research funding data to compare funding for and publication of gun violence research with that for 30 other leading causes of death in the United States.

Comment & Response

Allergenic Food Introduction and Childhood Risk of Allergic or Autoimmune Disease

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JAMA. 2017;317(1):86. doi:10.1001/jama.2016.18329

Generalizability in Pragmatic Trials

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JAMA. 2017;317(1):87-88. doi:10.1001/jama.2016.18332

Allergenic Food Introduction and Childhood Risk of Allergic or Autoimmune Disease—Reply

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JAMA. 2017;317(1):87. doi:10.1001/jama.2016.18339

Generalizability in Pragmatic Trials—Reply

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JAMA. 2017;317(1):88. doi:10.1001/jama.2016.18342

Updated Recommendations for Cost-effectiveness Studies

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JAMA. 2017;317(1):89-90. doi:10.1001/jama.2016.17824

Updated Recommendations for Cost-effectiveness Studies

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JAMA. 2017;317(1):89. doi:10.1001/jama.2016.17833

Updated Recommendations for Cost-effectiveness Studies—Reply

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JAMA. 2017;317(1):90. doi:10.1001/jama.2016.17839

Missing Negative Symbol

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JAMA. 2017;317(1):90. doi:10.1001/jama.2016.18691

Language Change

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JAMA. 2017;317(1):90. doi:10.1001/jama.2016.18967

Omission of Funding/Support and Role of the Sponsor Acknowledgments and Disclaimer

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JAMA. 2017;317(1):90. doi:10.1001/jama.2016.19548
Medical News & Perspectives

23andMe, Big Data, and the Genetics of Depression

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JAMA. 2017;317(1):14-16. doi:10.1001/jama.2016.14136

This Medical News article discusses the use of consumer data for disease genomics research.

Lab Reports

Long-Acting Oral Drug Device May Help Combat Malaria

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JAMA. 2017;317(1):17. doi:10.1001/jama.2016.18686

Implantable Device Reverses Leg Paralysis in Monkeys

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JAMA. 2017;317(1):17. doi:10.1001/jama.2016.19835

Pancreatic Cancer Blocked From Invading Nearby Nerves

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JAMA. 2017;317(1):17. doi:10.1001/jama.2016.19837
News From the Food and Drug Administration

New Tool to Study Zika Virus

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JAMA. 2017;317(1):18. doi:10.1001/jama.2016.19026

Reducing Recurrent Strokes

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JAMA. 2017;317(1):18. doi:10.1001/jama.2016.19075

Relief for Painful Intercourse

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JAMA. 2017;317(1):18. doi:10.1001/jama.2016.19077
The Arts and Medicine

Pure Genius, the TV SeriesIs There an ICD-10 Code for Hyperbole?

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JAMA. 2017;317(1):10-11. doi:10.1001/jama.2016.19011

This Arts and Medicine essay reviews the 2016 ABC TV series Pure Genius, which imagines health care in a futuristic hospital founded by a Silicon Valley entrepreneur to provide high-tech care for complex patients.

Poetry and Medicine

The Body

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JAMA. 2017;317(1):91. doi:10.1001/jama.2016.15675
JAMA Revisited


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JAMA. 2017;317(1):92. doi:10.1001/jama.2016.18575
JAMA Patient Page

Respiratory Syncytial Virus

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JAMA. 2017;317(1):98. doi:10.1001/jama.2016.17882
JAMA Masthead


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JAMA. 2017;317(1):7-8. doi:10.1001/jama.2016.12933