This randomized clinical trial compares the effects of survival of the MEK inhibitor selumetinib plus docetaxel vs docetaxel alone as second-line therapy for advanced KRAS-mutant non–small cell lung cancer.
This study describes withdrawals, boxed warnings, and safety communications affecting pharmaceuticals and biologics approved by the US Food and Drug Administration between 2001 and 2010, and associations between characteristics known at the time of approval and those events.
This study surveyed international nephrology society leaders, policy makers, and patient representatives to assess regional resources and ability to care for patients with kidney disease.
This cohort study uses UK primary care database data to explore the association between long-term quinine exposure and all-cause mortality.
This Recommendation Statement from the US Preventive Services Task Force recommends against screening for thyroid cancer in asymptomatic adults (D recommendation).
This Evidence Report to support the 2017 update of the US Preventive Services Task Force Recommendation Statement on screening for thyroid cancer summarizes evidence about the benefits and harms associated with thyroid cancer screening and treatment of early thyroid cancer in asymptomatic adults.
This Viewpoint discusses recommendations the US National Academies of Sciences and Medicine made in 2017 for the application and oversight of human genome editing in basic research, clinical disease, and germline cells.
This Viewpoint discusses the complexities of the health disparities in the United States and argues for better integration of genomic basis for understanding health disparities with social models of disease and disparities.
This Genomics and Precision Health essay discusses the risks and potential benefits of performing genome sequencing in healthy people.
This Medical News story follows up on the recent downgrading of a form of thyroid cancer to a noncancerous neoplasm.
This Arts and Medicine essay reviews the 2-act chamber opera The Center Cannot Hold, which tells the story of Elyn Saks, who developed schizophrenia in childhood but went on to become a law professor and mental health advocate.
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