This randomized clinical trial compares the effects of bevacizumab vs aflibercept on visual acuity among patients with macular edema due to central retinal or hemiretinal vein occlusion.
This randomized trial compares the effects of cephalexin plus trimethoprim-sulfamethoxazole vs cephalexin alone on clinical cure rate among patients with uncomplicated cellulitis.
This randomized clinical trial compares the efficacy and safety of ferric carboxymaltose vs saline to treat acute isovolemic anemia following gastrectomy.
This study uses national Medicare data to compare 30-day mortality among patients hospitalized or undergoing surgical procedures in teaching vs nonteaching hospitals between 2012 and 2014.
This study uses obstetric readmission rates from the 2013 National Readmission Database to describe hospital variance in postpartum readmissions and the percentage of variance attributed to hospital factors.
This Viewpoint argues that conventional definitions of medication reconciliation overlook the need to identify the correct list of medicines for patients, and discusses the challenges involved in defining who should be involved in defining and maintaining that list.
This Viewpoint uses the example of the US FDA’s 2017 approval of desmopressin for treatment of nocturia to discuss the risks of approving a drug for symptoms rather than disease and the ways that the drug approval process is influenced by manufacturers and by overreliance on statistical vs clinical significance.
This Viewpoint describes measures needed for an effective NIH policy in which a single IRB would work with multiple local IRBs to ensure protection of participants in multisite trials.
This Viewpoint defines mindsets—frames of mind that orient beliefs or expectations—discusses how they can influence patients’ perceptions about treatment and self-efficacy, and proposes ways physicians might shape patients’ mindsets during clinical encounters to enhance treatment effectiveness.
This review offers guidance on medical and psychotherapeutic treatment options available for older frail patients with depression and who are taking several types of medications.
This commentary discusses a study published in JAMA Oncology that compared quality and cost outcomes for breast cancer care in Taiwan with a pay-for-performance bundled-payment program vs fee-for-service payment programs.
A 19-day-old Japanese male infant presented with a 12-day history of low-grade fevers and erythematous plaques with central atrophy and raised margins on the forehead and periorbital areas. Laboratory testing showed mild anemia and an elevated C-reactive protein level. What would you do next?
This Medical News article discusses how epigentic changes in a father’s sperm may influence his descendants’ health.
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