In this Viewpoint, Chobanian proposes blood pressure goals for treatment of hypertension in light of data from the ACCORD, SPRINT, and HOPE-3 trials, which tested differences in patient outcomes by treatment targets.
This Viewpoint discusses potential threats to public health that arise from provisions of the 2016 21st Century Cures Act that allow drug manufacturers to use surrogate measures of safety and that encourage the US Food and Drug Administration to emphasize speed over science in the drug approval process.
This Viewpoint discusses examples of intentional equivocation (hedging) in clinical practice guidelines from professional societies and proposes that less certain or actionable recommendations be removed from guidelines and published in other formats.
This randomized clinical trial evaluates whether a scalp cooling device is effective compared with no cooling for reducing alopecia in women with breast cancer undergoing chemotherapy.
This cohort study evaluates associations between use of a scalp cooling system and self-assessed hair loss and quality of life among women receiving chemotherapy for early-stage breast cancer at US medical centers.
This randomized clinical trial compares the effects of 2 years of sublingual grass pollen immunotherapy vs placebo on nasal symptom scores in adults with moderate to severe seasonal allergic rhinitis.
This genetic epidemiology study investigates associations between a polygenic risk score for waist-to-hip ratio adjusted for body mass index and risk of type 2 diabetes and coronary heart disease.
This JAMA Clinical Guidelines Synopsis summarizes a 2016 joint statement by international diabetes organizations recommending metabolic surgery for the treatment of type 2 diabetes in patients with a body mass index of 40 or higher.
A man in his 40s presented with fever, a rash, and progressing acneiform papules and pustules that began 3 days after taking ibuprofen for a mild headache. What would you do next?
This Medical Letter review summarizes background and prescribing information about combination sofosbuvir and velpatasvir, a recently approved oral treatment for all hepatitis C virus genotypes.
This study describes the 2-year outcomes for participants of a randomized trial of mindfulness-based stress reduction vs cognitive behavioral therapy or usual care for adult participants with chronic low back pain.
This Medical News article discusses theories explaining type 2 diabetes remission in patients who have undergone bariatric surgery.
This Arts and Medicine essay reviews The One With Friends, a theatre workshop that addresses mental illness, loneliness, and the importance of human connection for young single adults through an imagined reunion of characters from the TV show Friends 10 years after the show ended.