This crossover nonineriority trial compared the effects of insulin degludec with insulin glargine U100 in reducing on rates of symptomatic hypoglycemic episodes among adult patients with type 1 diabetes.
This randomized crossover clinical trial compares the effects of insulin degludec vs insulin glargine U100 on rates of hypoglycemia in patients with type 2 diabetes mellitus (T2DM).
This randomized 2 × 2 factorial trial compares the effects of hypothermia depth (32.0°C vs 33.5°C) and duration (72 vs 120 hours) on death and disability among infants with moderate or severe hypoxic-ischemic encephalopathy.
This report describes findings from 3 randomized clinical trials designed to compare the effects of a standardized exercise program with vs without radiofrequency denervation for treatment of chronic low back pain.
This cross-sectional study compared functional hearing with use of personal sound amplification products vs conventional hearing aid among older adults with mild to moderate hearing loss.
This Viewpoint identifies stakeholders in the financing and distribution of pharmaceuticals in the United States and describes their flow from manufacturers through distributors, managers, and retailers to patients.
This Viewpoint suggests that clinicians prescribe human insulin products as a more-affordable option over insulin analogues and explains dosing options.
This Viewpoint proposes that integration of patient goals, optimization of chronic disease management, and central record-keeping are essential if personalized care planning is to improve primary care and patient outcomes rather than simply burden primary care practices.
This Viewpoint discusses the 2017 National Academies of Sciences, Engineering, and Medicine (NASEM) report on improving the system of evaluation of genetic testing so that implementation of genomic medicine in clinical settings can be evidence-based.
This JAMA Insights article explains the association between prescribing antibiotics based on patients’ outdated history of penicillin allergy and the risk of increased antimicrobial resistance.
An asymptomatic 56-year-old woman had a nonsecreting heterogeneous adrenal mass with irregular margins and marked 18F-FDG uptake on PET imaging. What would you do next?
This Medical Letter review summarizes management of anaphylaxis and of insect bites and stings, including information about commercially available epinephrine auto-injectors for use by at-risk patients.
This Medical News article discusses efforts aimed at developing ovarian cancer screening and prevention strategies.