This noninferiority trial compares 10-year overall survival of women with invasive breast cancer and sentinel lymph node metastases treated with breast-conserving therapy and sentinel lymph node dissection alone vs axillary dissection.
This observational follow-up (cumulative 18 years) of postmenopausal women enrolled in 2 RCTs compared rates of all-cause, cardiovascular, and cancer mortality between groups receiving hormone therapy (conjugated equine estrogens [CEE] plus medroxyprogesterone acetate) or CEE alone vs placebo.
This cohort study assesses the risk of recurrence of gastroesophageal reflux after laparoscopic antireflux surgery and risk factors for reflux recurrence.
This mendelian randomization analysis of individual-participant data estimated the association between changes in levels of low-density lipoprotein cholesterol (and other lipoproteins) and risk of cardiovascular events due to CETP variants, alone and in combination with HMGCR variants.
This cross-sectional study compares the frequency of rupture of the distal biceps tendon in patients with wild-type transthyretin amyloidosis cardiomyopathy vs those with other causes of heart failure.
In this Viewpoint, 2017 Lasker-DeBakey Clinical Medical Research Award winners Douglas Lowy and John Schiller discuss the development of the virus-like particle technology that was used to create the human papillomavirus vaccine to prevent cervical cancer and other diseases.
In this Viewpoint, Cecile Richards on behalf of Planned Parenthood—the 2017 Lasker-Bloomberg Public Service Award winner—traces the 100-year history of the organization’s provision of medical and reproductive health services to US women and the effect of those services on women’s health, well-being, and career trajectories.
This Viewpoint discusses physician and patient factors that affect clinical decision making and may lead to diagnostic errors during the treatment of patients.
This JAMA Clinical Guidelines Synopsis summarizes the 2016 American College of Gastroenterology’s guideline on diagnosis, treatment, and prevention of acute diarrheal infections in adults.
A 39-year-old man with a history of ischemic stroke presented with right calf swelling and shortness of breath and was diagnosed with pulmonary embolism by CTPA. Testing 2 days later showed elevated titers of anticardiolipin and anti–β2 glycoprotein I antibodies and negative lupus anticoagulant screening assays. How would you interpret these results?
This Medical News article discusses findings that a meningococcal vaccine might also protect against gonorrhea.
Create a personal account or sign in to: