This randomized clinical trial compares clinically guided vs genotype-guided dosing to assess whether it improves the safety of warfarin initiation in patients undergoing elective hip or knee arthroplasty.
Three months after acute stroke, this randomized clinical trial compares rates of death and disability among adult patients receiving continuous or nocturnal low-dose oxygen supplementation or control intervention (oxygen only if clinically indicated.
This population epidemiology study estimates county-level patterns in mortality rates for chronic respiratory diseases in the United States from 1980 through 2014.
This nonrandomized crossover trial evaluated associations between biotin supplement ingestion and the accuracy of common diagnostic assays that rely on biotinylation, such as tests of thyroid function, vitamin D, and prostate specific antigen.
This study uses a national survey of US adolescents to examine the prevalence and correlates of self-reported diagnosed concussions to target and monitor prevention efforts.
This study reanalyzes Swedish cohort data to assess the stability under alternative assumptions and models of a previous estimate of the heritability of autism spectrum disorder.
This Viewpoint notes that nutrition and health behavior change should become a core competency for all physicians and other health professionals working with patients at risk for nutrition-related chronic disease.
This Viewpoint describes the Priority Antimicrobial Value and Entry (PAVE) award, which has been proposed to address the problem of antimicrobial-resistant infections using limited public funds to shift to value-based payment for new, high-priority antimicrobial drugs.
This Viewpoint summarizes recommendations from a specialist roundtable meeting about requirements for and appropriate use of extracorpeal organ support for patients with critical illness or organ failure.
This narrative review summarizes recent advances in the prevention, diagnosis, and treatment of delirium and highlights critical areas for future research.
A 67-year-old man with granulomatous polyangiitis treated with prednisone and azathioprine has a positive galactomannan enzyme immunoassay and fungal cultures positive for Aspergillus fumigatus in bronchoalveolar lavage fluid obtained for evaluation of dyspnea and a cavitary pulmonary nodule. How would you interpret the test results?
This Medical Letter review summarizes safety concerns regarding proton pump inhibitors such as increased fracture risk, hypomagnesemia and QT prolongation, and acute interstitial nephritis.
This Medical News article discusses recent advances and challenges in the development of liquid biopsies for cancer management.